Eicosapentaenoic acid
EPA (Eicosapentaenoic Acid) Manufacturer | 90%-97% High Purity Omega-3 CAS: 10417-94-4 | The "Heart Health" Standard Source: Deep Sea Fish Oil (Sustainably Sourced) | Form: Ethyl Ester (EE) or Re-esterified Triglyceride (rTG) Certifications: ISO9001, HACCP, Halal, Kosher, FOS (Friend of the Sea) • Pharmaceutical Grade: Ultra-high purity (up to 95%) for clinical efficacy. • Targeted Action: Specifically concentrated for Cardiovascular & Mood Support. • Low Impurity: Molecularly Distilled to remove Heavy Metals, PCBs, and Dioxins. • Supply: Ready Stock in US/EU for fast distribution.
Introduction
Eicosapentaenoic Acid (EPA) is a long-chain Omega-3 polyunsaturated fatty acid (C20:5 n-3) that plays a critical role in cardiovascular physiology and inflammatory regulation. While standard fish oils contain only 18% EPA, our specialized fractionation technology allows us to produce High-Purity EPA concentrates (up to 95%).
Unlike DHA (which focuses on brain structure), EPA is the "functional" Omega-3, acting as a precursor to eicosanoids (prostaglandins-3, thromboxanes-3, leukotrienes-5) that actively reduce inflammation, improve blood flow, and regulate your mood.
Category：
Keywords：
eicosapentaenoic
cardiovascular
Functions
1.Cardiovascular Protection (Clinically Validated)
• Triglyceride Reduction: High-dose pure EPA is clinically proven to significantly lower plasma triglyceride levels (VLDL clearance) without raising LDL cholesterol (a side effect sometimes seen with DHA).
• Plaque Stability: Helps stabilize atherosclerotic plaques, reducing the risk of rupture and subsequent cardiovascular events.
2.Anti-Inflammatory Potency (MOA)
• Competition: EPA competes with Arachidonic Acid (Omega-6) for cyclooxygenase (COX) enzymes, shifting the body's balance towards anti-inflammatory mediators.
• Joint Health: Reduces joint stiffness and pain associated with rheumatoid arthritis.
3.Mood & Mental Wellness
• Depression Support: Clinical meta-analyses suggest that EPA (specifically formulations with >60% EPA ratio) is more effective than DHA in alleviating symptoms of depression by reducing neuro-inflammation.
Applications
• Pharmaceuticals (API):
○ Hypertriglyceridemia Drugs: Starting material for prescription-grade Omega-3 therapies.
• Dietary Supplements:
○ Heart Health Softgels: "EPA-Only" or "High-EPA" formulas for consumers focused on cholesterol management.
○ Mood Support: Specialized capsules of "EPA for Mood" .
• Functional Foods:
○ Fortified Oils: Used in premium salad oil blends (Cold application).
Flow Chart
1.Raw Material: Crude Fish Oil (from Anchovy/Sardine) or Algal Biomass.
2.Esterification: Conversion of Triglycerides to Ethyl Esters (EE) to lower boiling point.
3.Molecular Distillation: Repeated distillation under high vacuum to separate EPA from DHA and other fatty acids based on carbon chain length.
4.Urea Complexation / Chromatography: Advanced purification to remove saturated fats and isolate EPA to >90% purity.
5.Re-esterification (Optional): Enzymatic conversion back to rTG form for premium bio-availability.
6.Deodorization: Mild steam stripping to remove fishy odor.
7.Filtration & Packaging: 0.2μm filtration and nitrogen packing.
Quality Standard of Lactoferrin
Product: EPA 90% Ethyl Ester (Food Grade)
| Items | Specifications | Results |
| Appearance | Clear, colorless to yellow oil | Conforms |
| EPA Content (C20:5 n-3) | ≥ 90.0% (Area %) | 92.4% |
| DHA Content | ≤ 1.0% (Specific for pure EPA) | 0.3% |
| Acid Value | ≤ 1.0 mg KOH/g | 0.1 |
| Peroxide Value | ≤ 5.0 meq/kg | 2.5 |
| Anisidine Value | ≤ 15.0 | 7.8 |
| Total Oxidation (TOTOX) | ≤ 20.0 | 12.8 |
| Heavy Metals (Pb, Hg, Cd, As) | ≤ 0.1 ppm each | Not Detected |
| PCBs & Dioxins | Meets EU/GOED Limits | Conforms |
Note: We also supply EPA 18% / DHA 12% ratios and other custom specs.
Method of Analysis of Lactoferrin
Gas Chromatography (GC) is the standard method (Ph. Eur. / USP).
• Column: Polyethylene glycol (PEG) stationary phase is typically used to ensure separation of the critical EPA peak from C18:4 n-3 and DHA.
• Standardization: Calculations are based on comparison with a high-purity EPA reference standard to ensure quantitative accuracy for "mg/g" labeling claims.
Reference Chromatogram of Lactoferrin Reference Substance
(Image Placeholder: GC Chromatogram of 90% EPA)
The chromatogram illustrates a singular, dominant peak for EPA (>90% total area), demonstrating the efficacy of our separation technology. The absence of significant DHA or Saturated Fat peaks confirms the high specificity of the product.
Stability and Safety
Stability Studies
• Oxidative Stress: Pure EPA is extremely reactive to oxygen.
• Antioxidants: Stabilized with alpha-Tocopherol (Vitamin E) or Rosemary Extract.
• Storage: Best stored under inert gas (Nitrogen/Argon) in minimal headspace containers.
• Shelf Life: 24 months at <20°C. Refrigeration (2-8°C) is highly recommended for 90%+ purity grades to maintain low TOTOX values.
Safety & Handling (MSDS Summary)
• Classification: GRAS.
• Safety: Safe for consumption. High doses (>3g/day) may increase bleeding time; consult a physician if on anticoagulants.
• Handling: Avoid heat and light. Use nitrogen flush after opening.
Customer Comments
Product Manager, Cardiologist-Formulated Brand, USA
2026.04.07
★★★★☆
Purchasing Director, Contract Manufacturer, Belgium
2026.04.07
★★★★☆
Our Certificates
CERTIFICATE
CERTIFICATE
FDA
ISO
HALAL
HACCP
Our Clients
Exhibitions
• CPhI Worldwide (Pharma Ingredients)
• SupplySide West (Las Vegas)
• Vitafoods Europe(Barcelona)
FIC Shanghai
FIC2024
CPHI Korea
SupplySideWEST Las Vegas
SupplySideWEST 2023
Vitafoods Europe Switzerland
Wagri Guangzhou
In-Cosmetics Global
SupplySide West (Las Vegas)
SupplySide West (Las Vegas)
CPHI & PMEC China 2025
CAC 24th
CAC Shanghai
CPHI & PMEC 2024
CPHI & PMEC China Shanghai
CPHI 2025
CPHI 2024
CPHI 2023
FIC 2022
FIC 2023
Vitafoods Europe (Geneva)
CPhI Worldwide
FAQ
What is the difference between EE (Ethyl Ester) and TG (Triglyceride)?
• EE: The form naturally resulting from molecular distillation. Higher concentration (up to 97%). slightly lower absorption rate initially, but effective with meals. • rTG (Re-esterified Triglyceride): EE converted back to TG form. Superior bioavailability and absorption, but higher cost due to the extra processing step. We supply both.
Why choose High-EPA over standard Fish Oil?
Standard fish oil (18:12) is for general health. High-EPA (>90%) is a targeted therapeutic ingredient. It allows for a clinical dose (e.g., 2g EPA) in just 2 small softgels, improving patient compliance compared to swallowing 6-7 large standard capsules.
Is your EPA free from radiation/contaminants?
Yes. We source small, short-lived fish (Anchovies) from the clean waters of Peru/Chile, and our molecular distillation process removes virtually all environmental pollutants (PCBs, heavy metals), meeting strict EU and Proposition 65 standards.
References
1.Bhatt, D. L., et al. (2019). Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. New England Journal of Medicine. (REDUCE-IT Trial).
2.Sublette, M. E., et al. (2011). Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. Journal of Clinical Psychiatry.
3.Yokoyama, M., et al. (2007). Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. The Lancet.
4.Mozaffarian, D., & Wu, J. H. (2011). Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. Journal of the American College of Cardiology.
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