Carprofen
Carprofen Manufacturer | Veterinary NSAID API (CAS: 53716-49-7) Source: Synthetic API | Purity: ≥99% (HPLC) | Certifications: ISO9001, Kosher, Halal USP:Veterinary Anti-Inflammatory API | Stable Supply |Custom Documentation Support
Introduction
Carprofen (CAS: 53716-49-7; Chemical Formula: C₁₅H₁₂ClNO₂) is a propionic acid-class non-steroidal anti-inflammatory drug (NSAID), chemically designated as 2-(6-chloro-9H-carbazol-2-yl)propionic acid. It was developed by Roche (Rimadyl) in 1981 and has been widely used in veterinary medicine due to its potent anti-inflammatory, analgesic, and antipyretic activities. It appears as a white or off-white crystalline solid, freely soluble in ethanol and organic solvents but practically insoluble in water. The molecule has a chiral center and exists as a racemic mixture of (S)-(+) and (R)-(-) enantiomers.
Category：
Keywords：
bromelain
activity
Bromelain
Functions
1.Mechanism of Action
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that primarily acts through inhibition of cyclooxygenase (COX) activity, resulting in reduced prostaglandin synthesis. It exhibits anti-inflammatory, analgesic, and antipyretic properties.
2.Pharmacological Profile
Carprofen demonstrates high plasma protein binding and favorable pharmacokinetic characteristics in veterinary applications. It is mainly metabolized in the liver and eliminated through both fecal and urinary pathways.
Applications
1.Veterinary Clinical Use
(1)Canine osteoarthritis: Used for the management of chronic pain and inflammation associated with degenerative joint disease.
(2)Postoperative pain management: Commonly used following soft tissue and orthopedic surgery.
(3)Acute musculoskeletal disorders: Applied in cases involving trauma, sprains, and inflammatory conditions.
2.Research Applications
(1)Pharmacological studies involving NSAID and COX inhibition mechanisms.
(2)Reference compound for veterinary anti-inflammatory drug development and efficacy evaluation.
Flow Chart
Carprofen is manufactured through a multi-step organic synthesis process involving condensation, cyclization, hydrolysis, purification, and drying procedures. The crude product is further refined by recrystallization to achieve the required purity and quality specifications.
The final product is dried under controlled conditions and packaged in sealed, light-resistant containers to maintain stability during storage and transportation.
Quality Standard of Lactoferrin
Product: Carprofen 99%
CAS No.: 53716-49-7
| Item | Specification | Result |
| Appearance | White crystalline powder | Conforms |
| Assay (HPLC) | ≥99.0% | 99.5%% |
| Dry weight loss | ≤0.5% | 0.1 |
| Heavy Metals | ≤20 ppm | 0.03 |
| Single unknown immpurity | ≤0.1% | 0.09 |
| Ash content | ≤0.1% | 0.005 |
Method of Analysis of Lactoferrin
We utilize HPLC(High-Performance Liquid Chromatography)for assay determination and quality control analysis of Carprofen.
● Column:C18
● Detector:UV Detector
● Mobile Phase:Organic solvent/aqueous buffer system
● HPLC analysis helps ensure batch-to-batch consistency and compliance with quality specifications.
Reference Chromatogram of Lactoferrin Reference Substance
The reference chromatogram typically shows a well-defined principal peak corresponding to Carprofen at the specified retention time. No significant impurity peaks are observed under standard analytical conditions, indicating good product purity and quality consistency suitable for veterinary and research applications.
Stability and Safety
Stability Studies
● Shelf Life: 24 months.
● Store in a sealed, dry, and light-resistant environment. Keep container tightly closed and protected from moisture during storage and transportation.
Safety
Carprofen demonstrates low toxicity under recommended veterinary usage conditions. Proper handling procedures and standard laboratory safety practices are recommended.
Customer Comments
Technical Manager, European Animal Health Company
2026.06.22
★★★★☆
Purchasing Manager, South Korean Veterinary Pharmaceutical Company
2026.06.22
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FAQ
What is the primary application of Carprofen?
Carprofen is primarily used in veterinary medicine as a non-steroidal anti-inflammatory drug (NSAID) for the management of pain, inflammation, and postoperative discomfort in animals, especially dogs.
What is the solubility of Carprofen?
Carprofen is freely soluble in ethanol and various organic solvents, while practically insoluble in water.
Is COA and technical documentation available?
Yes, COA, MSDS, and other related technical documents can be provided upon request.
What is the recommended storage condition?
Store in a cool, dry, and light-protected environment with the container tightly sealed to avoid moisture exposure.
Is Carprofen suitable for research applications?
Yes, Carprofen is commonly used in veterinary pharmacology studies and anti-inflammatory research applications.
References
1.Brien, S., et al. (2004). Bromelain as a treatment for osteoarthritis: a review of clinical studies. Evidence-Based Complementary and Alternative Medicine.
2.Pavan, R., et al. (2012). Properties and therapeutic application of bromelain: a review. Biotechnology Research International.
3.Maurer, H. R. (2001). Bromelain: biochemistry, pharmacology and medical use. Cellular and Molecular Life Sciences.
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