PDRN

Polydeoxyribonucleotide (PDRN) is a premium bioactive compound composed of purified deoxyribonucleotide fragments, primarily extracted from the sperm cells of salmon/trout, with plant-derived sources available for vegan formulation needs. It is a natural DNA polymer with high structural homology to human DNA, featuring excellent biocompatibility, low immunogenicity, and a well-proven safety profile.

Originally developed for clinical applications such as wound healing and musculoskeletal tissue regeneration, PDRN has gained global recognition in dermatology and aesthetic medicine for its potent anti-inflammatory, cell regeneration, and collagen synthesis effects. It serves as a dual-function core ingredient: a high-efficacy regenerative agent in medical devices and wound care products, and a luxurious anti-aging & barrier-repair active in high-end cosmetics. We offer standard grade PDRN with DNA sodium content ≥ 85%, available in both cosmetic grade and food grade, with full regulatory paperwork support.[Certifications](ISO 9001 | ISO 22000 | HACCP | Halal | Kosher | Non-GMO)

1.Tissue Regeneration & Wound Healing

PDRN exerts a dual mechanism to accelerate tissue repair: it provides ready-to-use nucleotide precursors for cell DNA synthesis via the DNA salvage pathway, reducing the metabolic burden of de novo nucleotide synthesis in damaged cells, thereby accelerating cell proliferation and regeneration. Meanwhile, it upregulates the expression of vascular endothelial growth factor (VEGF) to promote angiogenesis, significantly shortens bleeding and clotting time, accelerates wound closure, and reduces scar formation. It is clinically validated for applications in skin graft repair, burn wound healing, and soft tissue regeneration.

2.Anti-Inflammatory & Skin Barrier Repair

As a high-affinity agonist of the adenosine A₂A receptor, PDRN triggers downstream signaling cascades upon receptor binding, downregulates pro-inflammatory cytokines such as TNF-α, and effectively modulates excessive inflammatory responses. It can rebuild the skin's defensive barrier, repair damaged and sensitive skin, alleviate skin inflammation and discomfort, and is suitable for post-laser/procedure skin care and chronic sensitive skin conditioning.

3.Anti-Aging & Skin Rejuvenation

PDRN promotes fibroblast proliferation and collagen synthesis, improves skin microcirculation, metabolizes damaged cells, and activates the activity of senescent cells, thereby improving skin dryness, roughness, and fine lines/wrinkles. It also exhibits excellent reactive oxygen species (ROS) scavenging activity, inhibits melanin formation, and delivers comprehensive anti-aging, brightening, and deep moisturizing effects for the skin.

Low-Temperature Purification to Preserve DNA Fragment Activity & Integrity

1.Raw Material Screening: Qualified salmon sperm (or plant-derived raw materials) with full traceability, pre-tested for heavy metals and microorganisms.

2.Pretreatment: Degreasing, deproteinization, and impurity removal to retain high-purity nucleic acid components.

3.Lysis & Extraction: Controlled low-temperature lysis to release DNA fragments, avoiding damage to the active structure.

4.Purification: Multi-stage purification to remove residual proteins, lipids and other impurities, isolate target DNA fragments.

5.Molecular Weight Screening: Precise segmentation to retain active DNA fragments with molecular weight between 50-1500 kDa.

6.Concentration & Desalination: Low-temperature concentration to ensure product activity, with strict desalination process.

7.Sterilization: Aseptic filtration to meet microbial standards for cosmetic and food grade.

• Drying: Vacuum freeze drying (lyophilization) to preserve maximum biological activity.

• Milling: Controlled crushing to obtain uniform powder, passing 80 mesh sieve.

8.QC Testing: Full-panel testing including DNA sodium content assay, molecular weight distribution test, microbial and heavy metal inspection.

9.Packing: Airtight sterile bottles/drums with double PE inner bags.

Product: Polydeoxyribonucleotide (PDRN) 85% (Cosmetic/Food Grade)

• DNA Sodium Content: HPLC (High Performance Liquid Chromatography) for quantitative detection, the gold standard for PDRN content assay.

• Molecular Weight Distribution: Gel Permeation Chromatography (GPC) to verify the molecular weight range of active DNA fragments.

• Purity & Impurities: UV-Vis spectrophotometry for residual protein and nucleic acid purity detection; ICP-MS for heavy metal content testing.

• Microbial Limit Test: Performed in accordance with USP/CP/ISO standards, ensuring compliance with cosmetic and food grade requirements.

The HPLC fingerprint of our PDRN product shows the characteristic peak distribution of purified deoxyribonucleotide fragments, consistent with the international reference standard of salmon-derived PDRN. The IR spectrum exhibits characteristic absorption peaks of DNA sodium (phosphate group stretching, deoxyribose characteristic peaks), which can effectively distinguish it from adulterants such as short-chain nucleic acids, starch, and other polysaccharides, ensuring the authenticity and purity of each batch.

Stability Studies

• Shelf Life: 24 months under specified storage conditions.

• Storage: PDRN is sensitive to moisture and high temperature. It must be stored in tightly sealed, light-proof containers, in a cool and dry environment below 25°C.

• Solution Stability: Aqueous solutions are stable under neutral pH (5.0-7.5) and room temperature; sterile filtration and preservative addition are recommended for liquid formulations to prevent microbial growth. High temperature (>80°C) and extreme pH (below 3 or above 10) may cause degradation of DNA fragments and loss of biological activity.

Safety & Handling (MSDS Summary)

• Classification: Non-hazardous substance.

• Safety Profile: Proven safe for topical application and oral consumption (food grade). Non-irritating, non-sensitizing, low immunogenicity, no risk of BSE/TESE.

• Product Features: Gluten free, no allergen, Non-GMO, paraben free, no artificial colors.

• Handling: Avoid dust inhalation and long-term exposure to humid air; wear protective gloves and masks during operation.

• Storage: Cool, dry, well-ventilated place, away from direct sunlight and moisture.

1.Sini, M., et al. (2020). Polydeoxyribonucleotide (PDRN): A systematic review of its biological properties and clinical applications in tissue repair. Journal of Tissue Engineering and Regenerative Medicine.

2.Kim, H. J., et al. (2018). Efficacy of polydeoxyribonucleotide on skin rejuvenation and barrier repair: A clinical study. Journal of Cosmetic Dermatology.

3.Jeong, J. H., et al. (2016). Anti-inflammatory and wound healing effects of polydeoxyribonucleotide through activation of adenosine A2A receptor. International Journal of Molecular Sciences.