Tauroursodeoxycholic acid (TUDCA)
TUDCA Sodium Manufacturer | Advanced Liver Support & Chaperone Headline: Premium TUDCA (Sodium Tauroursodeoxycholate) Manufacturer | Neuroprotective & Liver Health API (CAS: 14605-22-2) Sub-headline: 99% Purity | Endoplasmic Reticulum (ER) Stress Reducer | Synthetic/Semi-Synthetic Grade Unique Selling Proposition (USP): • Cellular Guardian: Powerful "Chemical Chaperone" that reduces ER stress and prevents apoptosis (cell death). • High Bioavailability: Water-soluble bile salt with superior absorption compared to standard UDCA. • Dual Action: Protects both the Liver (Cholestasis) and the Brain (Neurodegeneration).
Introduction
Tauroursodeoxycholic Acid (commonly known as TUDCA), typically supplied as the sodium salt (Sodium Tauroursodeoxycholate, CAS: 14605-22-2), is an ambiphilic bile acid. It is the taurine conjugate of Ursodeoxycholic Acid (UDCA).
While naturally found in trace amounts in humans (and historically in bear bile), our industrial TUDCA is produced via a cruelty-free semi-synthetic process. It has gained massive traction in the Sports Nutrition and Longevity/Anti-Aging markets for its ability to clear toxic bile acids from the liver and reduce protein misfolding stress in cells, making it a premier organ support ingredient.
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sodium
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Functions
1.Liver Health & Bile Flow
• Mechanism: Stimulates bile secretion and displaces toxic hydrophobic bile acids.
• Action: Treats cholestasis (bile backup) and protects hepatocytes from damage caused by harsh oral steroids or alcohol.
2.Endoplasmic Reticulum (ER) Stress Relief
• Mechanism: Acts as a chemical chaperone.
• Action: Stabilizes protein folding in the ER. Reduces the "Unfolded Protein Response" (UPR), which is linked to insulin resistance and cell death.
3.Neuroprotection (Eye & Brain)
• Mechanism: Anti-apoptotic pathway inhibition (prevents Bax translocation).
• Action: Shows promise in slowing retinal degeneration (Retinitis Pigmentosa) and protecting neurons in models of ALS and Parkinson's.
Applications
1.Sports Nutrition (Cycle Support)
• Application: "On-Cycle" liver protection capsules.
• Why it works: Bodybuilders use it to mitigate liver toxicity caused by methylated prohormones or AAS.
2.Nootropics & Longevity
• Application: Anti-aging supplements.
• Why it works: Its cellular protective effects (mitochondrial health + ER stress reduction) align with life-extension and cognitive preservation goals.
3.Pharmaceutical Research
• Application: Investigational drug for ALS and Opthalmology.
• Why it works: Its ability to cross the blood-brain barrier (to some extent) and protect nerve cells.
Flow Chart
1.Starting Material: Ursodeoxycholic Acid (UDCA) + Taurine.
2.Activation: Activation of UDCA carboxyl group using coupling agents.
3.Conjugation: Reaction with Taurine under alkaline conditions.
4.Salt Formation: Conversion to Sodium Salt (for stability and solubility).
5.Purification: Ion exchange and crystallization to remove unreacted UDCA and impurities.
6.Drying: Spray drying or Vacuum drying.
7.Sieving: Particle size control (typically 80 mesh).
8.Packaging: Double PE bags in Drums.
Quality Standard of Lactoferrin
Product: Sodium Tauroursodeoxycholate (TUDCA)
CAS: 14605-22-2
| Item | Specification | Result |
| Appearance | White to off-white crystalline powder | Conforms |
| Assay (HPLC) | ≥ 98.0% (anhydrous basis) | 99.2% |
| Identification | IR / NMR / Mass Spec | Conforms |
| Specific Rotation | +40° to +50° | +44.5° |
| Loss on Drying | ≤ 5.0% | 2.8% |
| Heavy Metals | ≤ 20 ppm | < 10 ppm |
| Sodium (Na) | 3.5% - 4.5% | 4.1% |
| Related Substances | UDCA < 1.0% | 0.3% |
Method of Analysis of Lactoferrin
Test Method: HPLC (High-Performance Liquid Chromatography)
• Detector: Refractive Index (RI) or ELSD (Evaporative Light Scattering Detector) is often used because bile acids have weak UV absorption.
• Column: C18 Reverse Phase.
• Purpose: Ensures the complete conjugation of UDCA and Taurine, minimizing free UDCA content.
Reference Chromatogram of Lactoferrin Reference Substance
(Description)
The chromatogram should show a single, clean peak for TUDCA. The separation between TUDCA and its precursor UDCA is the critical quality indicator.
Stability and Safety
Stability Studies
• Hygroscopicity: Very Hygroscopic. TUDCA Sodium absorbs moisture rapidly from the air.
• Handling: Must be processed in low-humidity environments (<40% RH).
• Shelf Life: 24 Months when stored in tightly sealed containers. If exposed to moisture, it becomes sticky and degrades.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance.
• Taste: Extremely Bitter. Encapsulation is highly recommended over raw powder consumption.
• Storage: Store in a cool, dry place. Desiccants in packaging are mandatory.
Customer Comments
Product Developer, Hardcore Supps (USA)
2026.04.03
★★★★☆
CEO, Titan Nutrition (UK)
2026.04.03
★★★★☆
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FAQ
Is your TUDCA synthetic or from bear bile?
It is 100% Synthetic/Semi-synthetic. We start with bovine/poultry bile precursors (UDCA) and conjugate them chemically. No bears are harmed.
Can I mask the taste in a powder drink?
It is very difficult. TUDCA is one of the bitterest substances known. We strongly recommend capsules or masking with strong sweeteners and bitterness blockers if used in powder form.
What is the sodium content?
As it is a sodium salt (Sodium Tauroursodeoxycholate), it contains approximately 4% sodium by weight. This improves water solubility significantly compared to the free acid.
References
1.Amaral, J.D., et al. (2009). "Bile acids: regulation of apoptosis by ursodeoxycholic acid and tauroursodeoxycholic acid." Pharmacology & Therapeutics.
2.Ozcan, U., et al. (2006). "Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes." Science.
3.Vang, S., et al. (2014). "The unexpected uses of urso- and tauroursodeoxycholic acid in the treatment of non-liver diseases." Global Advances in Health and Medicine.
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