Quercetin Dihydrate Manufacturer
Quercetin Dihydrate Manufacturer | Natural Flavonoid & Immune Support (CAS: 117-39-5 / 6151-25-3) Source: Sophora japonica (Flower Bud) | Purity: 95% / 98% (HPLC/UV) | Certifications: ISO9001, Kosher, Halal, Non-GMO USP: High Potency Antioxidant | Respiratory Health Support | Ready Stock in Local Warehouse
Introduction
Quercetin Dihydrate (CAS: 6151-25-3 / 117-39-5) is a highly bioactive bioflavonoid extracted from the flower buds of the Pagoda Tree (Sophora japonica). As one of the most abundant dietary flavonoids, it is renowned for its powerful antioxidant capacity and its role in modulating the body's immune response.
Unlike anhydrous quercetin, the dihydrate form contains two water molecules in its crystal lattice, which contributes to its stability and specific solubility profile suitable for various nutraceutical formulations. It acts as a free radical scavenger and a natural antihistamine.
Category：
Keywords：
quercetin
dihydrate
Functions
1.Cell Culture Dissociation
• Mechanism: Hydrolyzes extracellular matrix proteins.
• Action: Detaches adherent cells from culture vessels and dissociates tissue into single-cell suspensions without damaging the cell membrane (when used correctly).
2.Protein Hydrolysis
• Mechanism: Cleaves peptide bonds specifically after basic amino acids (Lysine, Arginine).
• Action: Used to produce hypoallergenic infant formulas (by breaking down allergenic proteins) and bioactive peptides.
3.Wound Debridement
• Mechanism: Proteolytic digestion of necrotic tissue.
• Action: Helps remove dead tissue from wounds (often in combination with Chymotrypsin), promoting faster healing and reducing infection risk.
Applications
• Dietary Supplements: The primary ingredient in "Immune Defense" and "Allergy Relief" capsules and tablets (often combined with Vitamin C or Bromelain).
• Functional Foods & Beverages: Used as a natural antioxidant additive in oils, beverages, and meat products to extend shelf life and provide health benefits.
• Pharmaceuticals: Utilized as an API or intermediate for drugs targeting chronic bronchitis and hypertension (acts as an expectorant and antitussive).
• Cosmetics: Added to anti-aging creams for its ability to reduce inflammation and protect skin from UV-induced oxidative stress.
Flow Chart
Our extraction process ensures high purity and retention of bioactivity:
1.Raw Material: Harvesting Sophora japonica flower buds (Huai Mi).
2.Extraction: Alkaline extraction followed by acid precipitation.
3.Hydrolysis: Enzymatic or acid hydrolysis to convert Rutin (if present) to Quercetin.
4.Purification: Recrystallization to remove impurities.
5.Drying: Controlled drying to achieve the Dihydrate form (retaining crystal water).
6.Milling: Micronization to required mesh size (typically 95% pass 80 mesh).
Quality Standard of Lactoferrin
Product: Quercetin Dihydrate 95%
CAS No.: 117-39-5 (Anhydrous ref) / 6151-25-3 (Dihydrate)
| Item | Specification | Result |
| Appearance | Yellow crystalline powder | Conforms |
| Assay (HPLC/UV) | ≥95.0% | 95.6% |
| Loss on Drying | ≤4.0% | 2.5% |
| Residue on ignition | ≤0.5% | 0.08% |
| Heavy Metals (Pb) | ≤10 ppm | < 5 ppm |
| Arsenic (As) | ≤2 ppm | < 1 ppm |
| Particle Size | 95% pass 80 mesh | Conforms |
| Microbiology | Total Plate Count < 1000 CFU/g | Conforms |
Method of Analysis of Lactoferrin
• HPLC: The preferred method for quantifying Quercetin content, ensuring separation from related flavonoids like Kaempferol and Isorhamnetin.
• UV-Vis: Commonly used for total flavonoid estimation.
• Note: For Dihydrate, the water content (Loss on Drying) is a critical quality parameter confirming the crystal structure.
Reference Chromatogram of Lactoferrin Reference Substance
The HPLC chromatogram shows a dominant peak for Quercetin at the specific retention time. Minor peaks corresponding to other Sophora flavonoids are minimized to meet the >95% purity specification.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Conditions: Stable under normal storage. The dihydrate form is chemically stable but should be protected from strong light which can cause color darkening.
• Data: Samples stored at 25°C/60% RH remained within specification for 2 years.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous natural extract.
• GRAS Status: Generally Recognized As Safe in the US for specific food uses.
• Handling: Avoid breathing dust. Wear a dust mask and gloves.
• Storage: Store in a cool, dry place. Keep container tightly closed.
Customer Comments
Production Manager, Supplement Manufacturer, USA
2026.04.02
★★★★☆
R&D Specialist, Functional Food Brand, Germany
2026.04.02
★★★★☆
Our Certificates
CERTIFICATE
CERTIFICATE
FDA
ISO
HALAL
HACCP
Our Clients
Exhibitions
Meet Manager Jin Xinli and our team at:
• SupplySide West (Las Vegas)
• Vitafoods Europe (Geneva)
• CPhI Worldwide
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CPHI & PMEC China Shanghai
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SupplySideWEST Las Vegas
SupplySideWEST 2023
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In-Cosmetics Global
SupplySide West (Las Vegas)
SupplySide West (Las Vegas)
Vitafoods Europe (Geneva)
CPhI Worldwide
FAQ
What is the difference between Quercetin Anhydrous and Dihydrate?
Chemically, they are the same active molecule. Dihydrate contains two water molecules per Quercetin molecule (approx. 10-12% water by weight). Dihydrate is the most common commercial form due to its stability and better solubility profile for absorption.
Is your Quercetin synthetic or natural?
Our product is 100% Natural, extracted from the flower buds of Sophora japonica (Pagoda Tree). We do not use synthetic sources.
What is the recommended dosage?
Typical daily dosages range from 250 mg to 1000 mg, often split into two doses. Bioavailability can be enhanced when taken with fats or combined with Bromelain.
References
1.Li, Y., et al. (2016). "Quercetin, inflammation and immunity." Nutrients.
2.Boots, A.W., et al. (2008). "Health effects of quercetin: from antioxidant to nutraceutical." European Journal of Pharmacology.
3.Harwood, M., et al. (2007). "A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity." Food and Chemical Toxicology.
4.Davis, J.M., et al. (2009). "Quercetin reduces susceptibility to influenza infection following stressful exercise." American Journal of Physiology.
5.Egert, S., et al. (2009). "Quercetin reduces systolic blood pressure and plasma oxidised LDL concentrations in overweight subjects." British Journal of Nutrition.
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