Ectoine
Ectoine Manufacturer | Natural Extremolyte for Cellular Protection (CAS: 96702-03-3) Source: Microbial Fermentation (Halomonas elongata) | Purity: $\ge$ 99% (HPLC) | Certifications: ISO9001, COSMOS/Ecocert Approved, Halal USP: Ultimate Anti-Stress Molecule | 7-Day Hydration Retention | Ready Stock in Local Warehouse
Introduction
Ectoine (CAS: 96702-03-3; Chemical Name: 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid) is a powerful, multifunctional active ingredient derived from extremophilic microorganisms. These "extremophiles" produce Ectoine to survive in lethal conditions of high salinity, extreme temperature, and intense UV radiation.
As a natural cell protectant (osmolyte), Ectoine stabilizes cellular structures and biomolecules by forming a "Ectoine Hydro Complex" — a protective hydration shell around cells, proteins, and enzymes. This makes it a gold-standard ingredient for anti-aging, anti-pollution, and sensitive skin formulations.
Category：
Keywords：
ectoine
ingredient
Functions
1 Cellular Protection & Anti-Aging
Ectoine prevents UV-induced damage (photo-aging) by shielding Langerhans cells and preserving DNA integrity. It reduces the release of stress heat-shock proteins, effectively slowing down the cellular aging process.
2.Deep & Long-Lasting Hydration
It significantly improves skin moisture content. Studies show that Ectoine strengthens the skin barrier function (TEWL reduction) and maintains hydration for up to 7 days after the last application.
3.Anti-Inflammatory & Soothing
By stabilizing cell membranes, Ectoine reduces the inflammation cascade. It is highly effective in soothing irritated, atopically prone, or allergic skin, reducing redness and itching (often used as a corticosteroid alternative in medical devices).
Applications
• Cosmetics:
○ Sensitive Skin Care: Creams and serums for rosacea, eczema-prone skin, and baby care.
○ Sun Care: SPF boosters and after-sun repair lotions.
○ Anti-Pollution: "City defense" mists to protect against PM2.5 and environmental toxins.
• Medical Devices: Eye drops (for dry eye syndrome), nasal sprays (for rhinitis), and lung inhalation solutions.
• Biotechnology: Protein stabilizer in enzyme formulations and PCR kits.
Flow Chart
Our production utilizes a patented "Milking Process" fermentation technology, ensuring sustainability and high purity:
1.Fermentation: Cultivation of halophilic bacteria (Halomonas elongata) in high-salinity media.
2.Induction: Osmotic shock triggers the bacteria to produce and release Ectoine (without cell lysis).
3.Filtration: Separation of biomass.
4.Desalination: Electrodialysis to remove salts.
5.Purification: Ion exchange and chromatography to remove protein and DNA residues.
6.Crystallization: Controlled crystallization to achieve >99% purity.
7.Drying: Sterile drying to a white crystalline powder.
Quality Standard of Lactoferrin
Product: Ectoine (Cosmetic/Pharma Grade)
CAS No.: 96702-03-3
| Item | Specification | Result |
| Appearance | White crystalline powder | Conforms |
| Assay (HPLC) | $\ge$ 99.0% | 99.6% |
| pH (1% Solution) | 6.0 – 8.0 | 7.2 |
| Loss on Drying | $\le$ 0.5% | 0.1% |
| Ash (Residue on Ignition) | $\le$ 0.1% | 0.03% |
| Heavy Metals (Pb) | $\le$ 10 ppm | < 2 ppm |
| Arsenic (As) | $\le$ 1 ppm | < 0.5 ppm |
| Specific Rotation | +139° to +143° | +141.5° |
| Microbiology | Total Plate Count < 100 CFU/g | Conforms |
Method of Analysis of Lactoferrin
• HPLC: Validated method to ensure purity and absence of by-products like Hydroxyectoine (unless specified as a mix).
• Specific Rotation: Critical for confirming the correct stereoisomer (S)-Ectoine, which is the biologically active form.
Reference Chromatogram of Lactoferrin Reference Substance
The HPLC profile displays a single, symmetrical peak at the retention time of Ectoine. No impurities related to fermentation media (proteins/endotoxins) are detected, ensuring high biocompatibility.
Stability and Safety
Stability Studies
• Shelf Life: 36 months (3 Years).
• Conditions: Extremely stable against heat (can be autoclaved), pH (1-9), and UV light.
• Data: No degradation observed after 6 months at 40°C/75% RH. Ideal for complex formulations.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous.
• Skin Compatibility: Excellent. Non-irritating, non-sensitizing. Safe for use around eyes and mucous membranes.
• Storage: Store in a cool, dry place.
Customer Comments
Product Manager, Derma-Brand, Germany
2026.03.31
★★★★☆
Formulator, Suncare Specialist, Australia
2026.03.31
★★★★☆
Our Certificates
SKS-Kosher
CERTIFICATE
CERTIFICATE
ISO9001
ISO22000
FDA
Our Clients
Exhibitions
Meet Manager Liu Zhenhua and our team at:
• In-Cosmetics Global (Paris)
• PCHi (Shanghai)
• Cosmoprof Asia (Hong Kong)
In-Cosmetics Global
SupplySide West (Las Vegas)
SupplySide West (Las Vegas)
Vitafoods Europe (Geneva)
CPhI Worldwide
FIC Shanghai
FIC2024
CPHI Korea
SupplySideWEST Las Vegas
SupplySideWEST 2023
Vitafoods Europe Switzerland
Wagri Guangzhou
CPHI & PMEC China 2025
CAC 24th
CAC Shanghai
CPHI & PMEC 2024
CPHI & PMEC China Shanghai
CPHI 2025
CPHI 2024
CPHI 2023
FIC 2022
FIC 2023
FAQ
What is the recommended dosage?
For daily hydration and anti-aging: 0.5% - 2.0%. For medical devices or intensive repair (eczema/wound care): 2.0% - 7.0%.
Is Ectoine natural or synthetic?
Our Ectoine is 100% Natural, produced via biotechnology (bacterial fermentation). We do not use chemical synthesis, ensuring the correct chirality and safety profile.
Can it protect against blue light?
Yes, studies indicate Ectoine protects skin cells from oxidative stress induced by Blue Light (HEV) and IR-A radiation, making it an essential ingredient for "Digital Aging" defense products.
References
1.Galinski, E.A., et al. (1993). "The protective role of compatible solutes in the adaptation of Halomonas elongata to salinity." Journal of General Microbiology.
2.Bunger, J., et al. (2001). "Ectoine: an effective natural substance to prevent UVA-induced premature photoaging." Skin Pharmacology and Physiology.
3.Bitop AG Studies. (Various clinical data on Ectoine in dermatitis and airway inflammation).
4.Graf, R., et al. (2008). "The multifunctional role of ectoine as a natural cell protectant." Clinics in Dermatology.
5.Marini, A., et al. (2014). "Ectoine-containing cream in the treatment of mild to moderate atopic dermatitis." Skin Pharmacology and Physiology.
Related Products
Our Global Presence：Pioneer Biotech | Pioneer Bio Inc. | Kono Chem | Kono Chem (RU)
P&K INTERNATIONAL PTE. LTD.