Ascorbyl Tetraisopalmitate
Ascorbyl Tetraisopalmitate Manufacturer | Oil-Soluble Vitamin C (CAS: 183476-82-6) Source: Synthetic (Esterification) | Purity:97% (HPLC) | Certifications: ISO9001, ISO22000, COSMOS Approved USP: Superior Absorption | High Stability vs. L-Ascorbic Acid | Non-Irritating
Introduction
Ascorbyl Tetraisopalmitate (also known as Tetrahexyldecyl Ascorbate; Chemical Formula:
C70H128O10 is a premium, oil-soluble derivative of Vitamin C designed to overcome the stability issues inherent to pure L-Ascorbic Acid. By esterifying Vitamin C with isopalmitic acid, we transform it into a lipophilic molecule (MW: 1129.76) that easily penetrates the skin’s lipid barrier.
Once absorbed, it is enzymatically converted back into free Vitamin C within the dermis, delivering potent antioxidant protection and collagen-boosting benefits without the irritation or rapid oxidation often associated with water-soluble Vitamin C.
Category：
Keywords：
vitamin
ascorbyl
tetraisopalmitate
Functions
1.Superior Skin Penetration
Unlike water-soluble Vitamin C (L-Ascorbic Acid), Ascorbyl Tetraisopalmitate is lipophilic. This allows it to pass through the stratum corneum's lipid bilayer approximately 3-4 times more effectively, ensuring delivery to the viable epidermis and dermis.
2.High Stability (Oxidation Resistance)
The esterification protects the ascorbate moiety from oxidation. It remains stable at high temperatures and in the presence of air, making it ideal for formulations where shelf-life and color stability are critical.
3.Powerful Antioxidant & Brightening
• Inhibits Melanogenesis: Suppresses tyrosinase activity to reduce hyperpigmentation and age spots.
• UV Protection: Mitigates DNA damage caused by UV-A and UV-B exposure.
• Collagen Synthesis: Stimulates fibroblasts to produce collagen, improving skin firmness.
Applications
• Anti-Aging Serums: Premium oil-based serums targeting wrinkles and loss of elasticity.
• Skin Brightening Creams: High-end whitening formulations where low irritation is required for sensitive skin.
• Sun Care: Added to sunscreens (SPF boosters) to neutralize free radicals generated by UV exposure.
• Makeup: Incorporated into foundations and lipsticks for functional skincare benefits.
Flow Chart
2-Hexyldecanal reacts with L-ascorbic acid directly under the action of catalyst and oxidant to form ascorbyl tetraisopalmitate; after extraction, washing, drying, concentration, purification and other post-treatments, ascorbyl tetraisopalmitate is obtained.
Quality Standard of Lactoferrin
Product: Ascorbyl Tetraisopalmitate (Cosmetic Grade)
CAS No.: 183476-82-6
| Items | Specifications |
| Appearance | Colorless to pale yellow liquid |
| Odor | A faint characteristic odor |
| Specific gravity (20℃) | 0.930-0.943 |
| Refractive (25℃) | 1.459-1.465 |
| Loss on drying | ≤0.3% |
| Residue on ignition | ≤0.10% |
| As | ≤3ppm |
| Pb | ≤2ppm |
| Hg | ≤1ppm |
| Cd | ≤1ppm |
| Assay | ≥97.0% |
Method of Analysis of Lactoferrin
We utilize HPLC (High-Performance Liquid Chromatography) for assay determination.
• Column: C18 Reverse Phase
• Detector: UV at 254 nm
• Why this matters: HPLC separates the tetra-ester from mono-, di-, and tri-esters, ensuring you receive the fully esterified, highly stable molecule (Tetra-substituted).
Reference Chromatogram of Lactoferrin Reference Substance
The chromatogram displays a single major peak at the retention time of Ascorbyl Tetraisopalmitate (>97% area). Minor peaks (impurities) are minimized through our molecular distillation process, ensuring the product is odorless and colorless.
Stability and Safety
Stability Studies
• Shelf Life: 24 months when stored properly.
• Heat Stability: Unlike L-Ascorbic acid which browns rapidly, our Ascorbyl Tetraisopalmitate withstands heating up to 80°C during formulation without degradation.
• Long-term Data: Samples stored at 25°C for 12 months showed no significant change in Color (APHA) or Assay, remaining within the specification of $\ge$ 97%.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous for transport.
• Skin Compatibility: Non-irritating. Safe for use in products for sensitive skin at typical dosages (0.5% - 3.0%).
• Storage: Store in a cool, dry place. Keep container tightly closed. Although stable, avoiding prolonged exposure to direct sunlight and air preserves freshness.
Customer Comments
R&D Director, French Skincare Brand
2026.03.31
★★★★☆
Purchasing Manager, Korean Cosmetic OEM
2026.03.31
★★★★☆
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FAQ
What is the recommended dosage for Ascorbyl Tetraisopalmitate?
For daily maintenance and antioxidant protection, 0.5% - 2.0% is sufficient. For intensive brightening or anti-aging treatments, concentrations up to 3.0% - 10.0% can be used safely.
How does it compare to other Vitamin C derivatives like MAP or SAP?
MAP (Magnesium Ascorbyl Phosphate) and SAP (Sodium Ascorbyl Phosphate) are water-soluble. Ascorbyl Tetraisopalmitate is oil-soluble, offering better penetration and a unique silky feel, making it superior for creams, oils, and anhydrous formulations.
Is it stable in formulation?
Yes, it is the most stable form of Vitamin C. It does not require low pH (acidic) conditions to be effective, meaning it can be formulated at a skin-neutral pH (5.0-6.0), reducing irritation risk.
References
1.Ochiai, Y., et al. (2006). "A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation." Journal of Dermatological Science.
2.Stamford, N.P. (2012). "Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives." Journal of Cosmetic Dermatology.
3.Fields, K., et al. (2009). "Topical Vitamin C: A useful agent for treating photoaging and other dermatologic conditions." Dermatologic Surgery.
4.Xiao, L., et al. (2011). "Permeation of Ascorbyl Tetraisopalmitate through excised human skin." International Journal of Pharmaceutics.
5.Farris, P.K. (2005). "Topical Vitamin C: A useful agent for treating photoaging." Obstetrics and Gynecology Clinics.
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