Naringin
Naringin Manufacturer | 98% High Purity Natural Bitter Agent CAS: 10236-47-2 | Source: Citrus Grandis (Pomelo) / Grapefruit Grade: Pharmaceutical & Food Grade | Specs: 50% - 98% HPLC | Certifications: ISO9001, HACCP, Kosher, Halal • Primary Source: Extracted from young Pomelo/Grapefruit fruit (Immature Citrus). • Dual Function: Natural Bittering Agent & Precursor for NHDC (Sweetener). • Bioactivity: Validated for cardiovascular health and bioavailability enhancement. • Supply Chain: Large-scale commercial production | Ready Stock in Xi'an.
Introduction
Naringin is a major bio-flavonoid glycoside found abundantly in grapefruits (Citrus paradisi) and pomelos (Citrus grandis), giving them their characteristic bitter taste.
As a professional manufacturer, we isolate high-purity Naringin (98%) primarily from the immature fruits of Citrus grandis (L.) Osbeck. It serves as a critical raw material in two distinct industries:
1.Flavor Industry: As a natural bittering agent to replace Quinine and modify sucrose perception.
2.Pharma & Synthesis: As the starting material for synthesizing Neohesperidin Dihydrochalcone (NHDC) and as a bioactive API for promoting microcirculation.
Category：
Keywords：
citrus
naringin
grapefruit
Functions
1.Flavor Modulation (Bitter Agent)
• Taste Profile: Distinctive bitter taste at low concentrations.
• Synergy: Enhances the perception of specific flavors and reduces the sweet aftertaste of certain high-intensity sweeteners.
2.Synthesis Precursor (For NHDC)
• Chemical Conversion: Naringin is chemically modified (via alkaline hydrogenation) to produce NHDC (Neohesperidin Dihydrochalcone), a sweetener 1500-1800 times sweeter than sugar with zero bitterness.
3.Bioavailability Enhancer (MOA)
• Enzyme Inhibition: Naringin and its metabolite (Naringenin) inhibit intestinal CYP3A4 enzymes and P-glycoprotein transporters.
4.Cardiovascular & Anti-inflammatory
• Microcirculation: Improves blood fluidity and reduces capillary fragility.
• Lipid Metabolism: Clinical studies suggest it helps lower LDL cholesterol and plasma triglycerides.
Applications
Food & Beverage:
• Tonic Water & Mixers: Natural replacement for Quinine.
• Confectionery: Used to create "sharp" or "adult" flavor profiles (e.g., dark chocolate, citrus candies).
Pharmaceuticals:
• Tablet/Capsule: Used in formulations for lowering blood pressure and cholesterol.
• Syrups: Used to mask unpleasant tastes of other medicines.
Raw Material Synthesis:
• Base material for the production of NHDC (E959) and Naringenin.
Flow Chart
1.Raw Material: Sourcing of Immature Pomelo Fruit (High Naringin content).
2.Extraction: Water/Alcohol extraction under controlled heat.
3.Filtration: Removal of plant fibers and insoluble impurities.
4.Crystallization: Cooling induced crystallization to isolate Naringin.
5.Recrystallization (Critical): Repeated purification to reach 98% Purity.
6.Drying: Vacuum drying at 110℃ to obtain Naringin Dihydrate form.
7.Milling: Pulverization to fine powder (80 mesh).
Quality Standard of Lactoferrin
Product: Naringin 98% HPLC
| Item | Specification | Result |
| Appearance | White to light yellow crystalline powder | Conforms |
| Assay (HPLC) | ≥ 98.0% | 98.4% |
| Identification | Matches the spectrum of the standard | Conforms |
| Loss on Drying | ≤ 10.0% (Dihydrate) | 8.2% |
| Ash | ≤ 0.5% | 0.1% |
| Heavy Metals | ≤ 10 ppm | < 10 ppm |
| Solubility | Soluble in alcohol, hot water | Conforms |
| Microbiology | Total Plate Count < 1000 CFU/g | Conforms |
Note: We also supply Naringin 50% - 90% cost-effective grades for animal feed applications.
Method of Analysis of Lactoferrin
High-Performance Liquid Chromatography (HPLC) is the gold standard for Naringin quantification.
• Detector: UV at 283 nm (Characteristic absorption peak of the flavanone structure).
• Column: C18 Reverse Phase.
• Significance: Ensures the distinction between Naringin and other citrus flavonoids (like Rhoifolin) to guarantee potency for NHDC synthesis.
Reference Chromatogram of Lactoferrin Reference Substance
(Image Placeholder: HPLC Chromatogram of Naringin 98%)
A high-quality chromatogram shows a single major peak at the retention time of Naringin (>98% area). Impurities such as Naringenin (the aglycone) should be minimal (<1%).
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Heat Stability: Naringin Dihydrate is relatively heat stable, making it suitable for bakery and boiled sweet production.
• Data: Under accelerated conditions (40°C/75% RH), the assay degraded less than 1.5% over 6 months.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous.
• Handling: Naringin powder can be dusty. Use dust extraction or wear a mask.
• Storage: Store in tightly closed containers. Moisture absorption can lead to caking (hygroscopic nature).
Customer Comments
Procurement Manager, Sweetener Manufacturer, Spain
2026.03.05
★★★★☆
Product Developer, Beverage Startup, USA
2026.03.05
★★★★☆
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FAQ
What is the difference between Naringin and Naringenin?
Naringin is the glycoside form (sugar attached), while Naringenin is the aglycone (sugar removed). Naringin is bitter and water-soluble; Naringenin is tasteless/bland and less soluble but has higher direct antioxidant activity. We supply both.
Can Naringin be used in beverages?
Yes, it is widely used as a bittering agent in beverages like tonic water, bitter lemon, and energy drinks. It provides a lingering bitterness that complements citrus flavors.
What is the solubility of Naringin?
It is sparingly soluble in cold water (0.1%) but highly soluble in hot water and alcohol. For beverage applications, we recommend dissolving it in hot water or propylene glycol first.
References
1.Chanet, A., et al. (2012). Citrus flavanones: what is their role in cardiovascular protection? Journal of agricultural and food chemistry, 60(36), 8809-8822.
2.Ribeiro, I. A., & Ribeiro, M. H. (2008). Naringin and naringenin determination in citrus extracts by HPLC. Journal of Liquid Chromatography & Related Technologies.
3.Zhang, J., et al. (2015). Pharmacological effects of naringin and its derivatives. Bioorganic & medicinal chemistry letters.
4.Pang, H., et al. (2020). Naringin: A potential immunomodulator in the treatment of inflammation-related diseases. Phytotherapy Research.
5.E959 (Neohesperidin DC) Production Guidelines.
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