Vitamin B15 (Pangamic Acid)
Vitamin B15 (Pangamic Acid) Manufacturer | 98% Purity CAS: 20858-86-0 | Cellular Respiration Activator & Methyl Donor Grade: Food & Pharmaceutical Grade | Assay: ≥99.0% | Form: White Crystalline Powder Certifications: ISO9001, HACCP, Halal, Kosher • Active Mechanism: Functions as a potent Methyl Donor involved in protein synthesis. • Key Benefit: Enhances oxygen utilization efficiency (anti-hypoxia) and supports liver health. • Supply: Commercial scale production | Ready Stock for immediate shipment.
Introduction
Vitamin B15, chemically known as Pangamic Acid, is a naturally occurring nutrient originally isolated from apricot kernels (and found in rice bran, brewer's yeast, and pumpkin seeds). While not a classical "vitamin" in the strict sense, it is widely recognized in the nutraceutical industry for its distinct biological activities.
Structurally, it is an ester derived from D-Gluconic Acid and Dimethylglycine (DMG). Our Vitamin B15 is produced under strict quality controls to ensure structural integrity and stability. It acts primarily as a Pan-Systemic Oxygenator, helping tissues utilize oxygen more efficiently and reducing the accumulation of lactic acid during metabolic stress.
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Keywords：
vitamin
b15
pangamic
Functions
1.Methylation Support (MOA)
• Methyl Donor: Vitamin B15 provides labile methyl groups required for the biosynthesis of creatine, phospholipids, and hormones.
• Detoxification: By participating in transmethylation processes, it aids the liver in detoxifying environmental toxins and metabolic waste products.
2.Anti-Fatigue & Oxygen Utilization
• Cellular Respiration: It stimulates oxidative phosphorylation enzymes, enhancing the oxygen uptake capacity of cells (Anti-hypoxia effect).
• Lactic Acid Reduction: Helps clear lactic acid from muscle tissue, thereby delaying the onset of fatigue and improving endurance in athletic performance.
3.Immunomodulation & Liver Protection
• Immune Response: Acts as an immunomodulator, potentially enhancing the body's non-specific resistance to infections.
Applications
Sports Nutrition:
• Pre-workout Formulations: Used in supplements designed to increase stamina, reduce recovery time, and improve VO2 max.
Functional Foods & Beverages:
• Energy Drinks: Added as an anti-fatigue agent.
Pharmaceutical & Health Supplements:
• Liver Health Support: Formulated into liver detox capsules.
• Cardiovascular Health: Used as a supportive ingredient for circulation and heart health (improving oxygen delivery).
Animal Nutrition:
• Racehorses/Camels: Performance enhancer to reduce acidosis and muscle fatigue.
Flow Chart
1.Reaction Synthesis: Esterification of D-Gluconic Acid with Dimethylglycine under controlled pH and temperature.
2.Neutralization: Adjustment to form the stable salt form (typically Calcium or Sodium salt, if applicable, or kept as acid).
3.Crystallization: Cooling to precipitate Vitamin B15 crystals.
4.Centrifugation & Washing: Separation of crystals from the mother liquor to remove impurities.
5.Recrystallization (Purification): Dissolving in solvent and re-crystallizing to achieve 98%+ purity.
6.Drying: Vacuum drying to remove solvent residues.
7.Sieving & Packaging: Passing through 80 mesh and packing in sealed drums.
Quality Standard of Lactoferrin
Product: Vitamin B15 (Pangamic Acid) 98%
| Items | Specifications | Results |
| Appearance | White to off-white crystalline powder | Conforms |
| Assay (Titration) | ≥ 98.0% | 99.2% |
| Identification | IR Spectrum matches standard | Conforms |
| Loss on Drying | ≤ 2.0% | 0.8% |
| Melting Point | 138°C - 142°C | 140.5°C |
| Heavy Metals | ≤ 10 ppm | < 5 ppm |
| Arsenic (As) | ≤ 2 ppm | Conforms |
| Microbiology | Total Plate Count < 1000 CFU/g | Conforms |
Method of Analysis of Lactoferrin
We utilize Titration (Potentiometric Titration) and FT-IR (Fourier Transform Infrared Spectroscopy) for quality verification.
• Titration: Accurately determines the purity based on the acid-base properties of the molecule.
• Identification: FT-IR fingerprinting ensures the chemical structure corresponds exactly to Pangamic Acid, ruling out simple mixtures of Gluconic acid and DMG.
Reference Chromatogram of Lactoferrin Reference Substance
(Image Placeholder: IR Spectrum of Vitamin B15)
The Infrared Absorption Spectrum exhibits characteristic peaks corresponding to the carboxylic acid ester linkage and the amine group, confirming the authentic synthesis of the Pangamic Acid molecule.
Stability and Safety
Stability Studies
• Hygroscopicity: Vitamin B15 powder is hygroscopic (absorbs moisture).
• Storage Conditions: Stability tests indicate that the product remains stable for 24 months when stored in sealed containers at temperatures below 25°C and low humidity. Exposure to moist air causes the powder to clump and potentially degrade.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance for transport.
• Handling: Avoid inhalation of dust. Standard PPE (gloves, mask) recommended.
• Storage: Keep container tightly closed in a dry and well-ventilated place.
Customer Comments
Product Developer, Sports Supplement Co., USA
2026.03.04
★★★★☆
Purchasing Manager, Animal Nutrition, Australia
2026.03.04
★★★★☆
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FAQ
Is Vitamin B15 a recognized vitamin?
Technically, it is not classified as a "vitamin" by the FDA today because no specific deficiency disease has been identified. However, it is widely recognized as a nutritional factor or "vitamin-like substance" (similar to Inositol or Carnitine) with specific physiological benefits.
What is the difference between Vitamin B15 and DMG?
Vitamin B15 (Pangamic Acid) is the ester of DMG (Dimethylglycine) and Gluconic Acid. While DMG is the active methyl donor component, the ester form (B15) is believed by some researchers to have superior bioavailability and synergistic effects on cellular respiration compared to DMG alone.
References
1.Krebs, E. T., et al. (1951). Pangamic acid (vitamin B15). International Record of Medicine.
2.Kendall, R. V., & Lawson, J. W. (2000). Recent findings on N,N-dimethylglycine (DMG): a nutrient for the new millennium. Townsend Letter for Doctors and Patients.
3.Stacpoole, P. W. (1977). Pangamic acid ("vitamin B15"): a review. World Review of Nutrition and Dietetics.
4.Telegdy-Kovats, L., et al. (1969). The occurrence of pangamic acid (vitamin B15) in nature. Zeitschrift für Lebensmittel-Untersuchung und Forschung.
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