Ellagic Acid
Ellagic Acid Manufacturer | Natural Skin Whitening & Antioxidant (CAS: 476-66-4) Source: Punica granatum (Pomegranate) / Galla Chinensis | Purity: 40% - 90% (HPLC) | Certifications: ISO9001, Kosher, Halal, Organic USP: Potent Tyrosinase Inhibitor | UV Radiation Protection | Ready Stock in Local Warehouse
Introduction
Ellagic Acid (CAS: 476-66-4; Chemical Formula: C$_{14}_6_8$) is a naturally occurring fused polyphenol found in numerous fruits and nuts, with commercial extraction primarily from Pomegranate peel (Punica granatum) or Gallnut (Galla Chinensis).
It is extensively recognized in the dermatological and nutraceutical fields as a dual-action ingredient: a powerful antioxidant that scavenges free radicals and a safe, effective skin-whitening agent approved by health authorities (e.g., KFDA) for its ability to inhibit melanogenesis.
Category：
Keywords：
ellagic
antioxidant
pomegranate
Functions
1.Skin Whitening (Melanogenesis Inhibition)
Ellagic Acid inhibits the activity of tyrosinase, the rate-limiting enzyme in melanin production. By chelating copper ions at the active site of the enzyme, it effectively reduces the formation of dark spots and hyperpigmentation, promoting a brighter, more even skin tone.
2.Photo-Protection & Anti-Aging
It protects collagen from degradation by inhibiting Matrix Metalloproteinases (MMPs) induced by UV-B radiation. This helps prevent photo-aging, reducing the appearance of wrinkles and preserving skin elasticity.
3.Potent Antioxidant & Anti-Inflammatory
As a polyphenol, it exhibits superior oxygen radical absorbance capacity (ORAC). It neutralizes reactive oxygen species (ROS) and reduces inflammation markers (IL-1$\beta$, TNF-), supporting both skin health and systemic cellular protection.
4.DNA Protection (Anti-Mutagenic)
Studies suggest Ellagic Acid binds to DNA, shielding it from carcinogenic chemicals (like nitrosamines) and preventing mutations, making it a valuable chemopreventive agent in dietary supplements.
Applications
• Cosmetics: A premium active ingredient in "Spot Correcting" serums, whitening creams, and sun-care products.
• Dietary Supplements: Capsules for "Inner Beauty" (Skin brightening from within) and "Cellular Health" (DNA protection).
• Functional Foods: Added to antioxidant beverages and health bars.
• Food Preservation: Used as a natural antioxidant to prevent lipid oxidation in fatty foods.
Flow Chart
1.Raw Material Selection: High-yield Blakeslea trispora or natural vegetable sources.
2.Extraction: Solvent extraction under controlled conditions.
3.Crystallization: High-purity crystal isolation.
4.Micro-encapsulation (Critical Step):
• For CWS (Cold Water Soluble): Embedding in starch/gum matrix to ensure water solubility and stability against oxidation.
• For Oil Suspension: Dispersion in vegetable oil carriers.
5.Drying: Low-temperature Spray Drying (to preserve bioactivity).
6.Sieving & Packaging: Nitrogen-flushed packaging to prevent oxidation.
Quality Standard of Lactoferrin
Product: β-Carotene 10% CWS Powder (Standard Spec)
| Item | Specification | Result |
| Appearance | Red-purple to dark red crystalline powder or beadlets | Conforms |
| Assay (UV) | ≥ 10.0% (Customizable: 1%, 20%, 30%, 96%) | 10.2% |
| Loss on Drying | ≤ 5.0% | 3.2% |
| Solubility | Dispersible in cold water (forming emulsion) | Conforms |
| Heavy Metals (Total) | ≤ 10 ppm | < 5 ppm |
| Arsenic (As) | ≤ 1 ppm | Conforms |
| Lead (Pb) | ≤ 1 ppm | Conforms |
| Microbiology | Total Plate Count < 1000 CFU/g | Conforms |
Note: Data based on internal batch testing. Specific COA available upon request.
Method of Analysis of Lactoferrin
We utilize UV-Vis Spectrophotometry and HPLC (High-Performance Liquid Chromatography) for assay determination, strictly adhering to GB 5009.83-2016 and USP/EP monographs.
• UV-Vis: Used for routine total carotenoid content verification.
• HPLC: Ensures the separation of β-Carotene from other carotenoid isomers (alpha, gamma) and degradation products, guaranteeing the purity of the active trans-isomer.
Reference Chromatogram of Lactoferrin Reference Substance
(Image Placeholder: HPLC Chromatogram of β-Carotene)
A valid chromatogram for our High-Purity β-Carotene displays a dominant peak for all-trans-β-carotene at the characteristic retention time, with minimal cis-isomer peaks. This indicates a high-quality production process that minimizes thermal degradation.
Stability and Safety
Stability Studies
β-Carotene is sensitive to oxygen, light, and heat. Our micro-encapsulation technology significantly enhances stability.
• Long-term Stability (24 Months): Samples stored at 25°C/60% RH showed Assay retention >95% and stable Appearance after 24 months.
• Accelerated Stability (6 Months): Under 40°C/75% RH, the product maintained critical quality attributes (Assay, Water Content, Microbiology) within Module 6 specifications.
Safety & Handling (MSDS Summary)
• Classification: Generally Recognized As Safe (GRAS) for food use. Non-hazardous.
• Storage: Critical. Must be stored in a cool, dry place, in tightly sealed light-resistant containers (aluminum foil bags recommended). Keep away from strong light and heat to prevent oxidation.
• Handling: Use standard PPE (mask, gloves). Avoid dust generation.
Customer Comments
Formulation Chemist, Skincare Brand, South Korea
2026.02.26
★★★★☆
Product Manager, Nutraceutical Co., USA
2026.02.26
★★★★☆
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FAQ
What is the difference between Pomegranate Extract and Pure Ellagic Acid?
Pomegranate Extract typically contains a mix of polyphenols (Punicalagins + Ellagic Acid) and is water-soluble, often used in foods (40% grade). Pure Ellagic Acid (90%) is a purified aglycone, less soluble in water but more potent for specific whitening and DNA protection applications.
How do I dissolve it in cosmetic formulas?
Ellagic Acid has low solubility in water and oil. For cosmetics, it is best dispersed in a polyol (like propylene glycol or butylene glycol) or neutralized with a base (like Arginine or Tromethamine) to form a soluble salt during the water phase heating.
Is it safe for sensitive skin?
Yes, Ellagic Acid is considered a mild whitening agent compared to Hydroquinone or Kojic Acid. It is generally well-tolerated and suitable for sensitive skin types.
References
1.Stahl, W., & Sies, H. (2003). Antioxidant activity of carotenoids. Molecular aspects of medicine, 24(6), 345-351.
2.Grune, T., et al. (2010). Beta-carotene is an important vitamin A source for humans. Journal of Nutrition, 140(12), 2268S-2285S.
3.Scientific Opinion on the re-evaluation of mixed carotenes (E 160a (i)) and beta-carotene (E 160a (ii)) as a food additive. EFSA Journal 2012;10(3):2593.
4.Boon, C. S., et al. (2010). Factors affecting the chemical stability of carotenoids in food systems. Critical reviews in food science and nutrition, 50(6), 515-532.
5.GB 5009.83-2016. National Food Safety Standard - Determination of Carotene in Food.
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