Fucoidan
Fucoidan Manufacturer | Marine Sulfated Polysaccharide (CAS: 9072-19-9) Source: Laminaria japonica / Undaria pinnatifida | Purity: 10% - 95% (UV/Gravimetric) | Certifications: ISO9001, Kosher, Halal, Organic USP: High Sulfate Content (>20%) | Immune System Modulator | Ready Stock in US/EU
Introduction
Fucoidan (CAS: 9072-19-9) is a complex sulfated polysaccharide found primarily in the cell walls of brown seaweeds such as Laminaria japonica, Undaria pinnatifida (Wakame), and Fucus vesiculosus. It is composed mainly of fucose and sulfate groups, along with minor amounts of galactose, xylose, and mannose.
Renowned for its broad spectrum of biological activities, Fucoidan is a "super-ingredient" in the nutraceutical and functional food industries. It is extensively researched for its immune-boosting, anti-viral, and anti-tumor properties, often referred to as the "Secret of Longevity" from marine diets.
Category：
Keywords：
fucoidan
sulfated
pinnatifida
Functions
1.Immune System Modulation
Fucoidan activates natural killer (NK) cells and macrophages, enhancing the body's innate defense mechanisms against pathogens. It stimulates the production of immune-signaling molecules (cytokines), helping to regulate immune responses.
2.Anti-H. pylori & Gut Health
It has a unique ability to bind to Helicobacter pylori bacteria, preventing them from adhering to the gastric lining. This helps in managing gastric ulcers and promoting overall gastrointestinal health.
3.Anti-Tumor Potential
Preclinical studies indicate that Fucoidan can induce apoptosis (programmed cell death) in cancer cells and inhibit angiogenesis (blood vessel formation) in tumors, making it a promising adjuvant in integrative oncology.
4.Anticoagulant & Antithrombotic
Due to its structural similarity to heparin, Fucoidan exhibits natural anticoagulant properties, supporting healthy blood flow and cardiovascular function (Note: Dosage must be controlled in supplements).
Applications
• Dietary Supplements: Capsules and liquid formulas for Immune Support, Gastric Health, and Post-Chemo Recovery.
• Functional Foods & Beverages: Added to health drinks, yogurts, and jellies for its bioactive benefits.
• Cosmetics: Used in high-end skincare for its anti-aging, moisturizing, and matrix metalloproteinase (MMP) inhibiting effects.
• Animal Health: Feed additive for aquaculture and pets to boost immunity and virus resistance.
Flow Chart
Our extraction process focuses on preserving the delicate sulfated groups which are crucial for bioactivity:
1.Harvesting: Sustainable sourcing of pollutant-free brown algae.
2.Washing & Drying: Removal of salt, sand, and impurities.
3.Extraction: Low-temperature aqueous extraction (avoiding harsh acids to protect structure).
4.Separation: Centrifugation to remove algal fiber.
5.Purification: Ultrafiltration (molecular weight cutoff) and ion-exchange chromatography to remove heavy metals and concentrate Fucoidan.
6.Concentration: Vacuum evaporation.
7.Sterilization & Drying: Spray drying into a fine powder.
Quality Standard of Lactoferrin
Product: Fucoidan Extract (Standardized)
CAS No.: 9072-19-9
| Item | Specification | Result |
| Appearance | White to light yellow powder | Conforms |
| Fucoidan Content | $\ge$ 85.0% (HPLC/UV/Gravimetric) | 88.2% |
| Sulfate Content | ≥ 20.0% | 23.5% |
| L-Fucose | ≥ 20.0% | 22.1% |
| Loss on Drying | ≤ 5.0% | 3.8% |
| Ash Content | ≤ 30.0% (Natural mineral content) | 21.5% |
| Heavy Metals (Pb) | ≤ 3 ppm | < 1 ppm |
| Arsenic (As) | ≤ 2 ppm | < 1 ppm |
| Iodine | ≤ 100 ppm | 45 ppm |
| Solubility | 100% Soluble in water | Conforms |
Method of Analysis of Lactoferrin
• HPLC: Determination of fucose content after acid hydrolysis.
• Sulfate Assay: Ion Chromatography (IC) or Turbidimetric method to quantify sulfate groups, which directly correlates with bioactivity.
• Total Sugar: Anthrone-sulfuric acid method (Colorimetric).
Reference Chromatogram of Lactoferrin Reference Substance
The HPLC profile of the hydrolyzed sample shows a dominant peak for L-Fucose, confirming the identity of the polysaccharide backbone. The molecular weight distribution is verified via GPC (Gel Permeation Chromatography).
Stability and Safety
Stability Studies
• Shelf Life: 36 months.
• Conditions: Stable powder, but hygroscopic.
• Data: Bioactivity (Sulfate content) remains stable for 3 years when stored at room temperature in sealed packaging. Solutions should be used within 24 hours or preserved.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous food ingredient.
• Allergen: Contains Algae/Seaweed. Potential risk for those with iodine sensitivity (unless de-iodinated).
• Storage: Store in a cool, dry place. Hygroscopic; keep container tightly closed.
Customer Comments
R&D Director, Supplement Brand, USA
2026.03.04
★★★★☆
Quality Manager, Contract Manufacturer, Canada
2026.03.04
★★★★☆
Our Certificates
CERTIFICATE
CERTIFICATE
FDA
ISO
HALAL
HACCP
Our Clients
Exhibitions
• Vitafoods Europe (Geneva)
• SupplySide West (Las Vegas)
• Hi Japan (Health Ingredients)
Vitafoods Europe (Geneva)
CPhI Worldwide
CPHI & PMEC China 2025
CAC 24th
CAC Shanghai
CPHI & PMEC 2024
CPHI & PMEC China Shanghai
CPHI 2025
CPHI 2024
CPHI 2023
FIC 2022
FIC 2023
FIC Shanghai
FIC2024
CPHI Korea
SupplySideWEST Las Vegas
SupplySideWEST 2023
Vitafoods Europe Switzerland
Wagri Guangzhou
In-Cosmetics Global
SupplySide West (Las Vegas)
SupplySide West (Las Vegas)
FAQ
What is the difference between Fucoidan from Undaria vs. Laminaria?
Undaria (Wakame) Fucoidan typically contains more galactose and is often researched for anti-viral effects. Laminaria (Kombu) Fucoidan is richer in fucose and is widely studied for immune modulation and anti-tumor support. We offer both sources.
Does it contain Iodine?
Naturally, seaweed extracts are high in iodine. However, we offer De-iodinated Fucoidan (<100 ppm) for applications where thyroid safety is a concern. Standard grades may contain higher iodine levels beneficial for general health.
How do you measure purity?
"Purity" can be confusing. Some measure total polysaccharides (crude), others measure specific Fucoidan content. We specify Total Fucoidan (based on Fucose + Sulfate) and provide a detailed breakdown to ensure transparency.
References
1.Fitton, J.H. (2011). "Therapies from Fucoidan; Multifunctional Marine Polymers." Marine Drugs.
2.Ale, M.T., et al. (2011). "Fucoidan from Sargassum sp. and its antioxidant activity." International Journal of Biological Macromolecules.
3.Shibata, H., et al. (2003). "Inhibitory activity of fucoidan on Helicobacter pylori attachment." Nutritional Science and Vitaminology.
4.Koyanagi, S., et al. (2003). "Oversulfated fucoidan inhibits tumor angiogenesis." Biochemical Pharmacology.
5.Wang, J., et al. (2008). "Structure and immunomodulatory activity of fucoidan." Carbohydrate Polymers.
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