Berberine hydrochloride
Berberine Hydrochloride Manufacturer | Natural AMPK Activator (CAS: 633-65-8) Source: Coptis chinensis / Phellodendron amurense | Purity: 97% (HPLC/Titration) | Certifications: GMP, ISO9001, Kosher, Halal USP: High Bioavailability | Solvent-Free Extraction | Ready Stock in US/EU
Introduction
Berberine Hydrochloride (CAS: 633-65-8; Chemical Formula: C₂₀H₁₈NO₄・Cl) is a quaternary ammonium isoquinoline alkaloid extracted from traditional medicinal plants such as Coptis chinensis (Goldthread) and Phellodendron amurense. It appears as a distinctive yellow crystalline powder with a strongly bitter taste.
Widely recognized in modern pharmacology as a "metabolic switch," Berberine HCl is a potent AMPK (Adenosine Monophosphate-Activated Protein Kinase) activator. It is extensively used in the pharmaceutical and nutraceutical industries for its validated efficacy in regulating glucose metabolism, lipid profiles, and supporting cardiovascular health.
Category：
Keywords：
activator
chinensis
Functions
1.Glucose Metabolism Regulation (AMPK Activation)
Berberine targets the AMPK pathway, often referred to as the "metabolic master switch." By activating AMPK, it enhances insulin sensitivity, stimulates glucose uptake in muscle cells (independent of insulin), and inhibits gluconeogenesis in the liver.
2.Lipid Profile Management
It lowers circulating cholesterol and triglycerides by stabilizing the Low-Density Lipoprotein Receptor (LDLR) mRNA. This upregulation of LDLR expression aids in the clearance of LDL-cholesterol from the bloodstream.
3.Gut Health & Antimicrobial Activity
Historically used as an antibiotic, Berberine HCl exhibits broad-spectrum antibacterial properties, effectively modulating gut microbiota and inhibiting pathogenic strains like E. coli and Staphylococcus aureus without decimating beneficial bacteria.
Applications
• Dietary Supplements: The primary ingredient in "Metabolic Support" and "Healthy Blood Sugar" formulations (Capsules/Tablets).
• Pharmaceuticals: Used as an API in various regions for the treatment of Type 2 Diabetes, hyperlipidemia, and intestinal infections.
• Functional Foods: increasingly added to medical foods targeting metabolic syndrome (Note: Bitter taste requires masking or encapsulation).
Flow Chart
Quality Standard of Lactoferrin
Product: Berberine Hydrochloride (97% Granule/Powder)
CAS No.: 633-65-8
| Item | Specification | Result |
| Appearance | Yellow crystalline powder | Conforms |
| Assay (HPLC) | 95.0~98.0% (Calculated on dry basis) | 97.79% |
| Identification | Matches Reference Standard | Conforms |
| Loss on Drying | ≤1.0% | Conforms |
| Residue on Ignition | ≤0.1% | Conforms |
| Heavy Metals (Pb) | ≤10 ppm | Conforms |
| Arsenic (As) | ≤2 ppm | Conforms |
| Total aerobic microbial count | ≤1000 CFU/g | Conforms |
| Yeast and Mold | ≤100 CFU/g | Conforms |
| E. coli | Negative | Conforms |
| Solubility | Soluble in hot water; slightly soluble in ethanol | Conforms |
Method of Analysis of Lactoferrin
We employ HPLC (High-Performance Liquid Chromatography) for precise assay and impurity profiling.
• Column: C18 Reverse Phase
• Mobile Phase: Acetonitrile : 0.1% Phosphoric Acid / SDS solution
• Detector: UV at 345 nm
• Validation: This method ensures the separation of Berberine from related alkaloids like Palmatine and Jatrorrhizine.
Reference Chromatogram of Lactoferrin Reference Substance
Stability and Safety
Stability Studies
• Shelf Life: 36 months (3 Years).
• Conditions: Stable under normal storage conditions.
• Data: Accelerated stability testing (40°C/75% RH for 6 months) confirms no significant degradation in Assay or increase in impurities. The crystal structure is robust against humidity if properly sealed.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous for transport.
• Toxicity: LD50 (Oral, Mouse) > 329 mg/kg.
• Handling: Product is a fine yellow powder that stains easily. Operators should wear dust masks, gloves, and lab coats to prevent inhalation and staining of skin/clothing.
• Storage: Store in a well-closed container. Protect from light and moisture.
Customer Comments
Senior Buyer, US Nutraceutical Corp
2026.02.04
★★★★☆
Quality Assurance Manager, European Brand
2026.02.04
★★★★☆
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FAQ
What is the difference between Berberine HCl and Berberine Sulfate?
Berberine Hydrochloride (HCl) is the most studied and bioavailable form used in the majority of clinical trials. It has better solubility and stability compared to the sulfate form.
Is your Berberine natural or synthetic?
Our product is 100% Natural, extracted from Coptis chinensis or Phellodendron amurense. We do not sell synthetic Berberine to ensure the holistic profile of the alkaloid is maintained.
What is the recommended dosage?
Clinical studies typically use dosages ranging from 500 mg to 1500 mg per day, divided into 2-3 doses (taken before meals). Always verify with local regulations for supplement limits.
References
1.Yin, J., et al. (2008). "Efficacy of berberine in patients with type 2 diabetes mellitus." Metabolism.
2.Kong, W., et al. (2004). "Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins." Nature Medicine.
3.Zhang, Y., et al. (2008). "Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine." The Journal of Clinical Endocrinology & Metabolism.
4.Wang, Y., et al. (2017). "Berberine and plant gut microbiota." Theranostics.
5.Cicero, A.F.G., et al. (2012). "Antidiabetic properties of berberine: from cellular pharmacology to clinical effects." Hospital Practice.
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