Oxisidized glutathione
Oxidized Glutathione (GSSG) Manufacturer | High-Stability Bioactive Ingredient (CAS: 27025-41-8) Headline: Premium Oxidized Glutathione (GSSG) Manufacturer | ≥90% High-Purity Formula (CAS: 27025-41-8) Sub-info: Bio-fermentation Source | High Stability in Formulations | ISO & FDA Registered Facility USP: Superior Formulation Stability | Ready Stock in US/EU | Full Batch Traceability
Introduction
Oxidized Glutathione (GSSG) (CAS: 27025-41-8) is the stable, disulfide form of glutathione. It is formed by the joining of two molecules of reduced glutathione (GSH) via a disulfide bond. While GSH is the active antioxidant, GSSG provides unmatched stability in liquid and cream formulations where the reduced form might prematurely oxidize.
As a professional B2B manufacturer, we provide High-Purity Oxidized Glutathione Powder (90% - 98%). Our GSSG is produced via a natural microbial fermentation process followed by advanced oxidative stabilization, ensuring a high-quality bioactive material for premium Cosmetics, Nutraceuticals, and Clinical Diagnostic applications.
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Functions
GSSG plays a crucial role in maintaining cellular redox balance and skin health.
1.Redox Signaling & Barrier Repair (MOA):
GSSG acts as a redox signaling molecule that triggers the skin's endogenous antioxidant defense systems. It supports the structural integrity of proteins and cell membranes, effectively soothing inflammation and promoting barrier repair.
2.Advanced Skin Moisturization:
By modulating cellular metabolic pathways, GSSG helps skin cells retain moisture at a deep level, improving overall skin texture and preventing dryness-induced irritation.
3.Anti-Inflammatory Efficacy:
Specifically formulated for cosmetics, GSSG reduces pro-inflammatory mediators, making it an ideal choice for products targeting sensitive, acne-prone, or redness-prone skin.
4.Synergistic Brightening:
When absorbed, the body can convert GSSG back into GSH (Reduced form) using the enzyme glutathione reductase. This provides a sustained release of antioxidant power for skin brightening and anti-melanogenesis.
Applications
• Anti-Inflammatory Cosmetics: Formulated into calming lotions, recovery creams, and soothing masks for stressed skin.
• Advanced Hydration Lines: Used in high-end serums and essences for its deep-level moisturizing properties.
• In-Vitro Diagnostics (IVD): Essential as a standard or reagent in clinical laboratories for measuring glutathione reductase activity.
• Nutritional Supplements: Used in "Complex Glutathione" formulas for systemic support of the body's natural antioxidant pool.
Flow Chart
Oxidative Stabilization Process:
1.GSH Fermentation: Production of high-quality Reduced Glutathione via microbial fermentation.
2.Controlled Oxidation: Precise biochemical oxidation to form the disulfide bond (GSSG).
3.Filtration & Concentration: Removal of impurities and concentration of the GSSG fraction.
4.Ion-Exchange Purification: High-purity isolation of GSSG molecules.
5.Crystallization: Low-temperature crystallization to ensure crystalline stability.
6.Vacuum Drying: Removes moisture to prevent degradation.
7.Sieving & Packaging: 80-mesh fine powder sifting and nitrogen-flushed packaging.
Quality Standard of Lactoferrin
Spec: Oxidized Glutathione ≥90.0% (Cosmetic/Pharma Grade)
| Item | Specification | Result |
| Active Ingredient | Oxidized Glutathione (GSSG) | ≥ 90.0% |
| Appearance | White to Off-white Powder | Conforms |
| Identification | Positive (HPLC/NMR) | Conforms |
| Loss on Drying | ≤ 5.0% | 2.8% |
| Heavy Metals (Pb) | ≤ 10 ppm | < 5 ppm |
| Lead (Pb) | ≤ 1.0 ppm | 0.2 ppm |
| Arsenic (As) | ≤ 1.0 ppm | 0.1 ppm |
| Mercury (Hg) | ≤ 0.1 ppm | < 0.05 ppm |
| Microbiology | Total Plate Count ≤ 1,000 cfu/g | Conforms |
Method of Analysis of Lactoferrin
• Analytical Method: High-Performance Liquid Chromatography (HPLC).
• Standard: Our testing follows USP/EP monographs where applicable. We utilize a specific C18 column to differentiate between Reduced (GSH) and Oxidized (GSSG) forms, ensuring the assay accurately reflects the disulfide content and molecular purity.
Reference Chromatogram of Lactoferrin Reference Substance
(Description): A high-purity GSSG chromatogram shows a sharp, isolated peak at the target retention time. The baseline is exceptionally clean, with the "Reduced form" impurity strictly controlled according to specification, ensuring formulation stility.ab
Stability and Safety
Stability Studies
• Shelf Life: 24-month (2-year) shelf life confirmed by long-term stability data.
• Long-term Stability: Tests conducted at 25°C ± 2°C / 60% ± 5% RH show that Appearance, Purity/Assay, and Water Content remain fully within specification for the 24-month duration.
• Accelerated Stability: 6-month data (40°C ± 2°C / 75% ± 5% RH) ensures the molecule remains stable during global shipping and varying warehouse storage temperatures.
• Consistency: All results at 0, 6, 12, and 24 months remained strictly within the specifications listed in the Module 6 Quality Standard table.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance. Does not carry a hazard classification according to EEC directives.
• Handling: Wear standard PPE (safety glasses, gloves, and mask) to prevent dust inhalation during bulk handling.
• Storage: Store in a cool, dry place; keep container tightly closed. GSSG is significantly more stable than GSH but still benefits from being kept away from extreme heat.
Customer Comments
R&D Director, South Korean Beauty Brand
2026.02.24
★★★★☆
Lab Manager, German Diagnostic firm
2026.02.24
★★★★☆
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FAQ
What is Oxidized Glutathione (GSSG)?
GSSG is the stable disulfide form of glutathione. It is used in formulations where high stability is required and can be converted back into the active reduced form (GSH) within the body.
What are the main benefits for skin?
The main benefits include deep hydration, reduction of chronic inflammation, and providing a stable source of glutathione for brightening effects.
How do you identify quality?
Quality is identified by HPLC Purity (≥90%), consistent whiteness, and low levels of residual moisture. We provide a full batch COA and support third-party testing.
References
1.Forman, H. J., et al. (2009). "Glutathione: Overview of its protective roles, measurement, and biosynthesis." Molecular Aspects of Medicine.
2.Lushchak, V. I. (2012). "Glutathione homeostasis and functions: Potential targets for medical interventions." Journal of Amino Acids.
3.Weschawalit, S., et al. (2017). "Glutathione and its antiaging and antimelanogenic effects." Clinical, Cosmetic and Investigational Dermatology.
4.Pompella, A., et al. (2003). "The role of γ-glutamyltransferase in facultative iron toxicity." Free Radical Biology and Medicine.
5.USP Monograph for Glutathione.
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