D-Raffinose pentahydrate
D-Raffinose Pentahydrate | Premium Prebiotic & Excipient Headline: High-Purity D-Raffinose Pentahydrate Manufacturer | 99% Crystalline (CAS: 17629-30-0) Sub-info: Source: Natural Plant Extraction (Cottonseed/Beet) | Non-GMO | Assay: ≥99.0% USP: Powerful Bifidogenic Factor • Organ Preservation Grade • Excellent Stability
Introduction
D-Raffinose Pentahydrate is a natural trisaccharide composed of galactose, glucose, and fructose. It is classified as a functional oligosaccharide with strong prebiotic properties. Unlike simple sugars, it is indigestible by human enzymes and reaches the colon intact, where it selectively feeds beneficial bacteria (Bifidobacteria and Lactobacilli).
Beyond nutrition, our high-purity crystalline Raffinose is a critical component in Organ Preservation Solutions (like UW Solution) due to its superior osmotic properties and ability to prevent cellular edema during hypothermic storage.
Category：
Keywords：
d-raffinose
pentahydrate
Functions
1.Prebiotic & Gut Health
Raffinose is a potent "Bifidus Factor." Clinical studies show that ingesting small amounts promotes the proliferation of beneficial gut flora, improves bowel regularity, and inhibits the growth of harmful bacteria like Clostridium perfringens, thereby reducing intestinal toxins.
2.Cryoprotection & Cell Preservation
In the pharmaceutical and medical fields, Raffinose is used as a cryoprotectant. It stabilizes cell membranes and proteins during freeze-drying (lyophilization) and low-temperature storage, making it essential for preserving vaccines, stem cells, and transplant organs.
3.Skin Moisturizing (Cosmetics)
Its unique crystalline structure binds water molecules effectively. When used in cosmetics, it provides deep hydration and supports the skin barrier function without the stickiness associated with glycerin.
Applications
Medical & Pharmaceutical:
• Organ Preservation Solutions: A key osmotic agent in UW (University of Wisconsin) solution for liver/kidney transplants.
• Vaccine Stabilizer: Protects biological activity during lyophilization.
Functional Foods:
• Prebiotic Supplements: Low-calorie fiber source for gut health powders.
• Anti-Allergy Foods: Some studies suggest it helps modulate the immune system (Th1/Th2 balance) to alleviate atopic dermatitis.
Cosmetics:
• Moisturizers: Used in high-end creams for its non-tacky humectant properties.
Flow Chart
Raw Material (Cottonseed Meal) → Extraction (Water/Ethanol) → Filtration → Decolorization (Activated Carbon) → Ion Exchange (Demineralization) → Concentration → Chromatographic Separation (Purification) → Crystallization → Centrifugation → Drying → Sieving → Packaging
Note: Our purification process removes potential allergens (gossypol) to non-detectable levels.
Quality Standard of Lactoferrin
| Item | Specification | Result |
| Appearance | White crystalline powder | Conforms |
| Assay (HPLC) | ≥ 98.0% | 99.4% |
| Specific Rotation | +103.0° to +107.0° | +105.2° |
| Loss on Drying | 13.0% - 17.0% (Pentahydrate) | 15.1% |
| Residue on Ignition | ≤ 0.1% | 0.03% |
| Heavy Metals | ≤ 20 ppm | < 5 ppm |
| Arsenic (As) | ≤ 3.0 ppm | < 0.2 ppm |
Method of Analysis of Lactoferrin
We use HPLC with Refractive Index (RI) Detection to ensure accurate quantification of Raffinose and separation from other sugars like Sucrose or Stachyose.
• Water Content: We strictly control the pentahydrate water of crystallization (approx 15%) to ensure crystal stability.
Reference Chromatogram of Lactoferrin Reference Substance
The chromatogram displays a single sharp peak for Raffinose. Impurities like Melibiose or Sucrose are typically below 0.5%, meeting the stringent requirements for pharmaceutical applications.
Stability and Safety
Stability Studies
• Shelf Life: 36 months (3 Years).
• Conditions: Chemically stable under neutral pH. Does not participate in Maillard reaction (non-reducing sugar), meaning it won't turn brown in formulations.
• Storage: Store in a cool, dry place. Crystalline form is relatively stable against humidity compared to amorphous sugars.
Safety & Handling (MSDS Summary)
• Classification: Food Ingredient / GRAS.
• Safety: Non-toxic. Excessive consumption (>15g/day) may cause transient flatulence due to fermentation in the gut.
• Handling: Standard food/pharma hygiene.
Customer Comments
Lab Director, US Biotech Company
2026.02.13
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Product Manager, Japanese Functional Food Brand
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FAQ
What is "Pentahydrate"?
It means each molecule of Raffinose is associated with 5 water molecules in its crystal structure. This is the stable, natural form of Raffinose (CAS 17629-30-0). The anhydrous form is very hygroscopic and unstable.
Is Raffinose a sugar? Does it spike blood sugar?
Chemically, it is a trisaccharide sugar. However, humans lack the enzyme (alpha-galactosidase) to digest it. Therefore, it does not cause a rapid spike in blood glucose and is considered safe for diabetics (low glycemic index).
Can it be used in skincare?
Yes. It is an excellent moisturizer. Unlike polyols (glycerin), it is not sticky even at high humidity. It also helps stabilize lamellar structures in emulsions.
References
1.Tomomatsu, H. "Health effects of oligosaccharides." Food Technology (1994).
2.Ben, S., et al. "Raffinose: Sources, processing and health benefits." Journal of Functional Foods.
3.Southard, J. H., & Belzer, F. O. "Organ preservation." Annual Review of Medicine (1995) (Reference for UW Solution).
4.Nagai, Y., et al. "Characterization of the prebiotic effect of raffinose on gut microbiota." Bioscience, Biotechnology, and Biochemistry.
5.Kikuchi, H., et al. "Cosmetic applications of raffinose." Journal of Applied Glycoscience.
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