Lumbrokinase
Lumbrokinase Powder | Fibrinolytic Enzyme API Headline: Premium Lumbrokinase Powder Manufacturer | High-Activity Fibrinolytic Enzyme (CAS: 556743-18-1) Sub-info: Source: Lumbricus rubellus | Assay: ≥98% / 20,000 IU/mg | ISO9001 & GMP Standard USP: Clinical-Grade Fibrinolysis • Ready Stock in US/EU • Enteric Coating Compatible
Introduction
Lumbrokinase, scientifically classified as a group of proteolytic enzymes (acidic proteins), is extracted from the alimentary canal of the earthworm Lumbricus rubellus. Unlike conventional thrombolytic agents, Lumbrokinase demonstrates a unique dual-action mechanism: it acts directly on fibrin and activates the body's intrinsic plasminogen system.
Our Lumbrokinase is produced via advanced bio-extraction and purification technologies, ensuring a high-purity, stable powder free from heavy metals and biological contaminants, making it the gold standard for cardiovascular health formulations.
Category：
Keywords：
lumbrokinase
fibrinolytic
metals
Functions
1.Potent Fibrinolytic Activity
• Lumbrokinase exhibits strong fibrin specificity. It directly hydrolyzes fibrinogen and fibrin, the structural mesh of blood clots, without affecting normal blood coagulation cascades, minimizing bleeding risks.
2.Activation of Plasminogen
• Indirect Thrombolysis: It stimulates the conversion of endogenous plasminogen into plasmin, enhancing the body's natural ability to dissolve clots.
• t-PA Promotion: Increases the release of tissue plasminogen activator (t-PA) from endothelial cells.
3.Blood Viscosity Reduction
• By degrading fibrinogen and inhibiting platelet aggregation, Lumbrokinase significantly reduces whole blood viscosity and plasma viscosity, improving microcirculation and oxygen delivery to tissues.
Applications
• Cardiovascular Dietary Supplements: Formulated into capsules (often enteric-coated) for stroke prevention, deep vein thrombosis (DVT) management, and hypertension support.
• Pharmaceutical Formulations: Used as an API in oral thrombolytic drugs for treating cerebral infarction and angina pectoris.
• Functional Foods: Added to circulation-support beverages and powders for elderly health maintenance.
Why it works: Its stability in the gastrointestinal tract (especially when enteric-coated) allows for high oral bioavailability compared to other enzymes like Nattokinase.
Flow Chart
Raw Material Selection (Lumbricus rubellus) → Cleaning & Homogenization → Low-Temperature Buffer Extraction (Protects Enzyme Activity) → Centrifugation & Filtration → Ultrafiltration (Purification) → Lyophilization (Freeze Drying) → Milling & Sieving → V-Blending → Final Quality Control (HPLC/Activity Test) → Packaging
Note: Our process maintains strict temperature controls (<4°C) during extraction to preserve maximum enzymatic activity.
Quality Standard of Lactoferrin
| Item | Specification | Result |
| Appearance | White to off-white lyophilized powder | Conforms |
| Assay (Enzyme Activity) | ≥ 20,000 IU/mg (or 98% Protein) | 20,150 IU/mg |
| Loss on Drying | ≤ 5.0% | 3.2% |
| Ash | ≤ 2.0% | 0.8% |
| Heavy Metals (Pb) | ≤ 2.0 ppm | < 0.5 ppm |
| Arsenic (As) | ≤ 1.0 ppm | < 0.1 ppm |
| Microbiology (Total Plate Count) | ≤ 1,000 cfu/g | < 100 cfu/g |
| E. Coli / Salmonella | Negative | Negative |
Method of Analysis of Lactoferrin
We utilize a validated Fibrin Plate Method and Chromogenic Substrate Assay to determine the biological activity of Lumbrokinase.
• Specificity: Ensures the measurement of actual fibrinolytic capability, not just total protein content.
• Accuracy: Calibrated against international standard references to guarantee dosage consistency for your finished products.
Reference Chromatogram of Lactoferrin Reference Substance
(Imagine a clean HPLC graph here)
The chromatogram displays a dominant peak at the specific retention time for Lumbrokinase fractions (F-III-1, F-III-2), indicating >98% purity. The flat baseline confirms the absence of degradation products or organic solvent residues.
Stability and Safety
Stability Studies
• Long-term Stability (24 Months): Samples stored at 25°C ± 2°C / 60% ± 5% RH maintained >95% enzyme activity after 2 years.
• Accelerated Stability (6 Months): Under 40°C ± 2°C / 75% ± 5% RH conditions, the product showed minimal activity loss (<5%), ensuring stability during global shipping.
• Consistency: Parameters such as Appearance, Enzyme Activity, and Water Content remained strictly within Module 6 specifications at all time points (0, 3, 6, 12, 24 months).
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance; generally recognized as safe (GRAS) for supplement use.
• Handling: Standard PPE (gloves, mask) recommended preventing dust inhalation.
• Storage: Crucial: Store in a cool, dry place (2-8°C recommended for long term) in tightly sealed containers to prevent moisture absorption and activity loss.
Customer Comments
Procurement Manager, Top-tier US Supplement Brand
2026.02.12
★★★★☆
R&D Director, German Pharma Company
2026.02.12
★★★★☆
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FAQ
What is the source of your Lumbrokinase?
It is extracted exclusively from Lumbricus rubellus (red earthworms), which are bred in a controlled environment to ensure high enzymatic activity and absence of soil contaminants.
What is the Mechanism of Action (MOA)?
Lumbrokinase works via two pathways: direct fibrinolysis (breaking down fibrin clots) and indirect activation of the plasminogen system (increasing endogenous t-PA). This makes it a potent yet safe support for healthy blood viscosity.
How do you identify quality?
Quality is defined by Enzymatic Activity (IU/mg) and Specific Activity. We guarantee ≥20,000 IU/mg. Beware of cheap "Earthworm Protein" powders that are merely ground earthworms with no enzymatic activity. Always request an Activity Assay Report.
References
1.Mihara, H., et al. "A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus." Japanese Journal of Physiology (1991).
2.Wang, R., et al. "The fibrinolytic and antithrombotic effects of lumbrokinase." Journal of Ethnopharmacology (2000).
3.Tang, Y., et al. "Lumbrokinase: Strong fibrinolytic activity and its clinical application." Chinese Medical Journal (2002).
4.Cooper, E.L., et al. "Earthworms: sources of antimicrobial and anticancer molecules." Advances in Experimental Medicine and Biology (2012).
5.Kasim, M., et al. "Improvement of blood viscosity and red blood cell deformability by lumbrokinase." Clin Hemorheol Microcirc. (2009).
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