Acacetin
Acacetin Manufacturer | Natural Flavonoid for Atrial Fibrillation Headline: High Purity Acacetin Manufacturer | Natural Anti-Arrhythmic Flavonoid (CAS: 480-44-4) Sub-headline: 98% HPLC Purity | Extracted from Robinia pseudoacacia / Saussurea involucrata | Cardio-Protective & Anti-Inflammatory Unique Selling Proposition (USP): • Cardiovascular Support: Potent atrial-selective potassium channel blocker, showing great promise for Atrial Fibrillation (AF) management. • Natural Origin: Derived from the flowers of the Black Locust tree (Robinia pseudoacacia) or Snow Lotus. • Research Grade: High assay (≥98%) suitable for pharmaceutical R&D and premium nutraceutical formulations.
Introduction
Acacetin (5,7-dihydroxy-4'-methoxyflavone), CAS No. 480-44-4, is a naturally occurring methylated flavone. It is an off-white to yellow needle-like crystal.
It has garnered significant scientific interest as a potential drug candidate for Atrial Fibrillation (AF) due to its ability to selectively block cardiac potassium channels (I_Kur, I_to, and I_KACh). Unlike conventional anti-arrhythmics, Acacetin offers a safer profile with minimal effects on ventricular function. It also exhibits strong anti-cancer, neuroprotective, and anti-inflammatory properties.
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Keywords：
acacetin
natural
Functions
1. Anti-Arrhythmic (Atrial Fibrillation)
• Mechanism: Selectively blocks ultra-rapid delayed rectifier K+ current (I_Kur) and acetylcholine-activated K+ current (I_KACh).
• Action: Prolongs atrial action potential duration and effective refractory period (AERP) without prolonging the QT interval, preventing AF recurrence.
2. Anti-Inflammatory & Antioxidant
• Mechanism: Inhibits the expression of iNOS and COX-2 enzymes and suppresses pro-inflammatory cytokines (TNF-α, IL-6).
• Action: Protects cells from oxidative stress and inflammation, beneficial for conditions like sepsis and neuroinflammation.
3. Anti-Cancer Potential
• Mechanism: Induces apoptosis and arrests cell cycle (G1/G2 phase).
• Action: Shown to inhibit proliferation in various cancer cell lines (prostate, breast, lung) by targeting the mitochondria-mediated apoptotic pathway.
Applications
1. Pharmaceutical R&D (Cardiology)
• Application: Investigational New Drug (IND) development for AF.
• Why it works: Its selectivity for atrial tissues minimizes the risk of ventricular pro-arrhythmia, a major side effect of current drugs.
2. Nutraceuticals (Heart Health)
• Application: Cardiovascular support supplements.
• Why it works: Natural flavonoid profile supports healthy heart rhythm and circulation.
3. Neuroprotection
• Application: Supplements for cognitive health.
• Why it works: Crosses the blood-brain barrier and protects neurons from glutamate-induced toxicity and ischemia/reperfusion injury.
Flow Chart
1.Extraction: Ethanol reflux extraction from Robinia pseudoacacia flowers.
2.Concentration: Vacuum evaporation to obtain crude extract.
3.Hydrolysis: Acid hydrolysis (if glycosides are present) to release the aglycone (Acacetin).
4.Purification: Silica gel column chromatography or high-speed counter-current chromatography (HSCCC).
5.Crystallization: Recrystallization in Methanol/Ethanol.
6.Drying: Vacuum drying.
7.Milling: Size reduction to fine powder.
8.Packaging: Glass bottles or aluminum foil bags.
Quality Standard of Lactoferrin
Product: Acacetin 98%
Source: Robinia pseudoacacia (Black Locust) / Saussurea involucrata
| Item | Specification | Result |
| Appearance | Light yellow to yellowish crystalline powder | Conforms |
| Assay (HPLC) | ≥ 98.0% | 98.6% |
| Residue on ignition | ≤0.2% | 0.1% |
| Loss on Drying | ≤ 1.0% | 0.4% |
| Heavy Metals | ≤ 20 ppm | Conforms |
| As | ≤ 2 ppm | Conforms |
| Total Plate Count | ≤1000cfu/g | Conforms |
| Yeast &Mold | ≤100cfu/g | Conforms |
Method of Analysis of Lactoferrin
Test Method: HPLC (High-Performance Liquid Chromatography)
• Column: C18 (ODS).
• Mobile Phase: Methanol : 0.4% Phosphoric Acid (Adjust ratio, e.g., 60:40).
• Wavelength: UV detection at 330 nm.
• Identity: Retention time matches standard; Melting point verification.
Reference Chromatogram of Lactoferrin Reference Substance
(Description)
A single sharp peak at the specific retention time for Acacetin. The chromatogram should be free from significant peaks of related flavonoids like Apigenin or Luteolin, indicating high purity.
Stability and Safety
Stability Studies
• Thermal Stability: Stable melting point >260°C.
• Light Sensitivity: Protect from light to prevent discoloration.
• Shelf Life: 24 Months when stored in cool, dark conditions.
Safety & Handling (MSDS Summary)
• Classification: Investigational compound. Not classified as hazardous for transport.
• Handling: Standard lab safety (gloves, mask).
• Storage: Store in a cool, dry place.
Customer Comments
Principal Investigator, CardioResearch Institute (USA)
2026.02.05
★★★★☆
R&D Chemist, PharmaSynthetics (Germany)
2026.02.05
★★★★☆
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FAQ
What is the main benefit of Acacetin over Apigenin?
Acacetin is the 4'-O-methyl derivative of Apigenin. This methylation improves its lipophilicity and metabolic stability, potentially enhancing its bioavailability and potency in specific targets like cardiac ion channels.
Is it synthetic or natural?
We supply Natural Acacetin extracted from plants like Robinia pseudoacacia. Synthetic options are available for scale-up if required, but natural is preferred for nutraceuticals.
Can it be used for prostate health?
Yes, research suggests Acacetin inhibits prostate cancer cell growth, making it an interesting candidate for men's health supplements, though more clinical data is needed.
References
1.Li, G.R., et al. (2008). "Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs." Circulation.
2.Singh, S., et al. (2020). "Acacetin: A simple flavone with complex and multifaceted therapeutic potential." Phytotherapy Research.
3.Wu, H., et al. (2012). "Multi-targeted therapy of cancer by acacetin." Cancer Letters.
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