Polyglutamic acid
Polyglutamic Acid (PGA) Manufacturer | The "Hyaluronic Acid Killer" (CAS: 25513-46-6) Headline: Premium Polyglutamic Acid Manufacturer | ≥98% Purity Fermentation Grade (CAS: 25513-46-6) Sub-info: 500x More Hydrating Than Hyaluronic Acid | High & Low Molecular Weights Available | 100% Vegan USP: Next-Generation Super Humectant | Non-Sticky & Silky Texture | Ready Stock in Global Warehouses
Introduction
Polyglutamic Corrosive (PGA) (CAS: 25513-46-6) is a actually happening, water-soluble biopolymer determined from aged soybeans (natto). Not at all like chemically synthesized polymers, our PGA is delivered through a green natural maturation prepare utilizing Bacillus subtilis.
As a specialized B2B producer, we offer High-Purity Polyglutamic Corrosive Powder (≥98%) in different atomic weights (Tall MW for surface impediment, Moo MW for profound entrance). It is revolutionizing the restorative industry by outflanking Hyaluronic Corrosive in water-holding capacity, skin versatility upgrade, and tangible profile, giving a "glass skin" impact without the tackiness.
Category：
Keywords：
polyglutamic
hyaluronic
manufacturer
Functions
PGA acts as a multifunctional hydro-active agent:
1. Prevalent Hydration Capacity (MOA):
PGA shapes a lattice-like hydrogel organize on the skin. Its one of a kind structure permits it to hold up to 5,000 times its weight in water (approx. 5-10 times more than Hyaluronic Corrosive). It not as it were captures dampness but too restrains the corruption of endogenous Hyaluronic Corrosive by blocking the hyaluronidase enzyme.
2. Skin Versatility & Smoothness:
By keeping up extraordinary hydration levels in the stratum corneum, PGA fills in fine lines caused by parchedness, unmistakably plumping the skin and progressing elasticity.
3. Brightening & Brightening:
Studies appear that PGA can repress melanin blend, working synergistically with other brighteners to decrease pigmentation and advance an indeed skin tone.
4. Supplement Conveyance System:
Due to its anionic nature, PGA can frame electrostatic complexes with cationic actives, upgrading the soundness and conveyance of other supplements in the formulation.
Applications
• Hydrating Serums: The unused "Gold Standard" for moisturizers, frequently showcased as "PGA Serums."
• Sheet Covers: Utilized as the essential humectant to convey an moment "plumping" effect.
• Hair Care: Acts as an anti-static operator and shapes a defensive film on hair shafts, lessening breakage (way better than silicone).
• Makeup preliminaries: Gives a smooth, non-sticky canvas for cosmetics application.
Flow Chart
Green Maturation Technology:
1.Strain Development: Bacillus subtilis (natto strain) fermentation.
2.Fermentation: Controlled generation of glutamic corrosive polymers in a fluid medium.
3.Filtration: Division of biomass from the fluid broth.
4.Precipitation: Utilizing food-grade ethanol to accelerate the polymer.
5.Purification: Ultrafiltration to expel pollutions and select particular atomic weights.
6.Drying: Freeze-drying or spray-drying to protect bioactivity.
7.Sieving & Pressing: In a controlled cleanroom environment.
Quality Standard of Lactoferrin
Spec: Polyglutamic Acid ≥98.0%
| Item | Specification | Result |
| Active Ingredient | Polyglutamic Acid (PGA) | 98.5% |
| Appearance | Brown liquid,allowing stratification | Conforms |
| pH (1% Solution) | 5.0 – 7.0 | 6.2 |
| Molecular Weight | 700 kDa - 2000 kDa (High MW) <10 kDa (Low MW) | 1200 kDa |
| Loss on Drying | ≤ 10.0% | 6.8% |
| Heavy Metals | ≤ 10 ppm | < 5 ppm |
| Lead (Pb) | ≤ 2.0 ppm | 0.4 ppm |
| Arsenic (As) | ≤ 2.0 ppm | 0.2 ppm |
| Microbiology | Total Plate Count ≤ 1,000 cfu/g | Conforms |
Method of Analysis of Lactoferrin
• Analytical Strategy: GPC (Gel Penetration Chromatography) and HPLC.
• Why it things: GPC is vital for confirming the Atomic Weight Dispersion. The redress MW is basic for performance—High MW for film-forming (dampness bolt) and Moo MW for entrance (profound hydration).
Reference Chromatogram of Lactoferrin Reference Substance
(Description): The GPC chromatogram appears a particular dispersion bend comparing to the target atomic weight extend (e.g., top at ~1000 kDa). The nonappearance of low-molecular-weight corruption items affirms the judgment of the polymer chain.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Conditions: Steady at room temperature.
• pH Soundness: Steady over a wide pH extend (4.0 - 10.0), making it congruous with most corrective actives counting Vitamin C and Retinol.
• Data: Long-term soundness tests appear no noteworthy drop in thickness or pH over 24 months.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous, food-grade root (Natto).
• Skin Security: Non-irritating and hypoallergenic.
• Handling: Wear cover to dodge clean inhalation.
• Storage: Store in a cool, dry put. Hyroscopic nature requires tight sealing.
Customer Comments
Item Designer, US Indie Excellence Brand
2026.02.05
★★★★☆
R&D Executive, Korean Skincare OEM
2026.02.05
★★★★☆
Our Certificates
SKS-Kosher
CERTIFICATE
CERTIFICATE
ISO9001
ISO22000
FDA
Our Clients
Exhibitions
• In-Cosmetics Global
• PCHi China
• Cosmoprof Worldwide
• SupplySide West
Vitafoods Europe (Geneva)
CPhI Worldwide
FIC Shanghai
FIC2024
CPHI Korea
SupplySideWEST Las Vegas
SupplySideWEST 2023
Vitafoods Europe Switzerland
Wagri Guangzhou
In-Cosmetics Global
SupplySide West (Las Vegas)
SupplySide West (Las Vegas)
CPHI & PMEC China 2025
CAC 24th
CAC Shanghai
CPHI & PMEC 2024
CPHI & PMEC China Shanghai
CPHI 2025
CPHI 2024
CPHI 2023
FIC 2022
FIC 2023
FAQ
Is PGA way better than Hyaluronic Acid?
It is not fundamentally "superior" but "complementary." PGA holds more water and shapes a smoother film, but HA enters in an unexpected way. The best comes about regularly come from combining both. In any case, for a non-sticky wrap up, PGA is superior.
Is it sticky?
No. Not at all like tall concentrations of Hyaluronic Corrosive which can feel tasteless, PGA takes off a smooth, smooth, "glass-like" wrap up on the skin.
How do you recognize quality?
Quality is distinguished by Immaculateness (≥98%), Color (White vs Yellow), and Solvency. High-quality PGA ought to break down into a clear, colorless, gooey solution.
References
1.Bajaj, I., & Singhal, R. (2011). "Poly (glutamic acid)–an developing biopolymer of commercial intrigued." Bioresource Technology.
2.Choi, J. C., et al. (2015). "Advancing impact of poly(gamma-glutamic corrosive) on the blend of sort I collagen." Diary of Microbiology and Biotechnology.
3.Ben-Zur, N., & Goldman, D. M. (2007). "The hydration and impediment properties of polyglutamic corrosive." Restorative Science.
4.Ogunleye, A., et al. (2015). "Poly-gamma-glutamic corrosive: generation, properties and applications." Microbiology.
5.Cosmetic Fixing Audit (CIR). "Security Appraisal of Polyglutamic Corrosive."
Related Products
Our Global Presence：Pioneer Biotech | Pioneer Bio Inc. | Kono Chem | Kono Chem (RU)
P&K INTERNATIONAL PTE. LTD.