Aloe Emodin Powder
Aloe Emodin Manufacturer | Natural Anthraquinone (CAS: 481-72-1) Source: Aloe vera / Rheum palmatum (Rhubarb) | Purity: 95% / 98% (HPLC) | Certifications: ISO9001, Kosher, Halal USP: High Purity Extraction | Potent Antimicrobial | Ready Stock in Local Warehouse
Introduction
Aloe Emodin (CAS: 481-72-1; Chemical Formula: C15H10O5 is a bioactive anthraquinone derivative primarily extracted from the latex of Aloe vera leaves and the roots of Rheum palmatum (Rhubarb). It appears as a distinct orange-yellow crystalline powder.
Distinct from Emodin (which is methylated), Aloe Emodin possesses a hydroxymethyl group, conferring it with specific pharmacological activities. It is widely researched for its laxative, antiviral, and anti-tumor properties, and is a key ingredient in pharmaceutical and cosmetic formulations targeting skin health and digestive wellness.
Category：
Keywords：
emodin
palmatum
Functions
1.Digestive Health (Laxative Effect)
Like other anthraquinones, Aloe Emodin stimulates colonic motility. It is metabolized by colonic bacteria into active forms that increase peristalsis, making it effective for relieving constipation and supporting bowel regularity.
2.Antimicrobial & Antiviral Activity
It exhibits broad-spectrum antimicrobial properties, inhibiting the growth of Staphylococcus aureus, H. pylori, and certain dermatophytes. Studies also suggest inhibitory effects against viruses such as Influenza and Herpes Simplex Virus (HSV).
3.Anti-Tumor Potential
Preclinical research indicates that Aloe Emodin may induce apoptosis in various cancer cell lines (including neuroectodermal tumors) by disrupting the cell cycle and modulating signaling pathways, making it a compound of interest in oncological research.
4.Skin Care (Anti-inflammatory)
In cosmetics, it is valued for its ability to reduce inflammation and promote wound healing, often used in formulations for acne-prone skin or soothing gels.
Applications
• Pharmaceuticals: API or intermediate for laxative preparations and antiviral medications.
• Dietary Supplements: Ingredient in "Detox" and "Digestive Cleanse" capsules (dosage strictly regulated).
• Cosmetics: Functional ingredient in acne treatments, shampoos (for scalp health), and skin repair creams.
• Agrochemicals: Investigated as a natural photodynamic insecticide against certain pests.
Flow Chart
Our extraction process maximizes yield while removing related impurities (like Rhein and Chrysophanol):
1.Raw Material: Dried Aloe vera latex or Rheum palmatum root.
2.Extraction: Ethanol/Water reflux extraction.
3.Concentration: Vacuum evaporation of the solvent.
4.Acid Hydrolysis: Converting glycosides to free aglycones (Aloe Emodin).
5.pH Adjustment & Extraction: Liquid-liquid extraction to separate Aloe Emodin from other anthraquinones based on acidity differences.
6.Crystallization: Recrystallization in Toluene or Ethanol to achieve high purity (>95%).
7.Drying & Micronization: Vacuum drying to produce the final orange powder.
Quality Standard of Lactoferrin
Product: Aloe Emodin 95% / 98%
CAS No.: 481-72-1
| Item | Specification | Result |
| Appearance | Orange-yellow fine powder | Conforms |
| Assay (HPLC) | ≥95.0% | 95.5% |
| Loss on Drying | ≤1.0% | 0.4% |
| Ash Content | ≤0.5% | 0.1% |
| Heavy Metals (Pb) | ≤10 ppm | < 5 ppm |
| Arsenic (As) | ＜2 ppm | < 1 ppm |
| Microbiology | Total Plate Count < 1000 CFU/g | Conforms |
Method of Analysis of Lactoferrin
• HPLC: The industry standard for distinguishing Aloe Emodin from its structural analogs (Emodin, Rhein, Chrysophanol).
• Column: C18 Reverse Phase
• Detector: UV at 254 nm or 435 nm
• Mobile Phase: Methanol : 0.1% Phosphoric Acid (Gradient Elution)
Reference Chromatogram of Lactoferrin Reference Substance
The chromatogram exhibits a single major peak at the retention time specific to Aloe Emodin. Critical separation resolution (>1.5) is maintained between the Aloe Emodin peak and the adjacent Emodin peak, ensuring the absence of cross-contamination.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Conditions: Sensitive to light and alkaline conditions (turns red in alkali).
• Data: Stable when stored in light-resistant containers at 25°C. Degradation observed if exposed to UV light for prolonged periods.
Safety & Handling (MSDS Summary)
• Classification: Irritant.
• Hazards: Causes skin and eye irritation. May cause respiratory irritation if inhaled.
• Storage: Store in a cool, dark place. Keep away from strong bases and oxidizers.
Customer Comments
Lab Manager, Biotech Research Institute, USA
2026.04.01
★★★★☆
Purchasing Agent, Cosmetic Ingredient Distributor, Spain
2026.04.01
★★★★☆
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FAQ
What is the source of your Aloe Emodin?
Depending on the customer's requirement and cost sensitivity, we can extract it from Aloe vera (typically higher cost, cosmetic preference) or Rheum palmatum (Rhubarb root, more cost-effective for industrial use).
Is it water-soluble?
No, Aloe Emodin is practically insoluble in cold water. It is soluble in hot ethanol, ether, and benzene. It dissolves in alkaline solutions (turning red) but may degrade; thus, neutral or slightly acidic formulations are preferred for stability.
Can it be used in food?
Regulatory status varies by country. In the EU and US, anthraquinones are strictly regulated in food due to potential laxative effects and safety concerns. It is primarily used in supplements (with warning labels), cosmetics, or research.
References
1.Pecere, T., et al. (2000). "Aloe-emodin is a new type of anticancer agent..." Cancer Research.
2.Eshun, K., et al. (2004). "Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries." Critical Reviews in Food Science and Nutrition.
3.Chen, H.C., et al. (2014). "Aloe-emodin induced estrogenic activity..." Food and Chemical Toxicology.
4.Grindlay, D., et al. (1986). "The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel." Journal of Ethnopharmacology.
5.Sydiskis, R.J., et al. (1991). "Inactivation of enveloped viruses by anthraquinones extracted from plants." Antimicrobial Agents and Chemotherapy.
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