Biotin
Biotin Manufacturer | The "Beauty Vitamin" for Hair, Skin & Nails Headline: Pure Biotin (Vitamin B7) Manufacturer | High Potency API & Feed Grade (CAS: 58-85-5) Sub-headline: 99%+ Purity (USP/EP) | 2% & 1% Triturations | Essential for Keratin Synthesis Unique Selling Proposition (USP): • Dual-Grade Availability: Supplying both Pure USP/EP crystalline powder for pharma/cosmetics and 2% Feed Grade premixes. • Keratin Booster: The clinically proven ingredient for strengthening hair follicles and nail plates. • Metabolic Essential: Critical coenzyme for metabolizing fats, carbohydrates, and amino acids.
Introduction
Biotin (Vitamin B7, Vitamin H), CAS No. 58-85-5, is a water-soluble B-complex vitamin. It appears as a white crystalline powder and is stable under heat but sensitive to strong alkalis and oxidizing agents.
As a fundamental coenzyme for carboxylases, Biotin is indispensable for energy production and the synthesis of fatty acids. In the B2B market, it is a top-tier ingredient for Hair, Skin & Nail supplements (Nutraceuticals) and a critical additive in animal nutrition to prevent hoof problems and improve coat quality.
imidazole-4-pentanoic acid]
Category：
Keywords：
biotin
coenzyme
Functions
1.Keratin Infrastructure
• Mechanism: Stimulates keratinocyte differentiation.
• Action: Increases the production of keratin, the structural protein in hair and nails. Clinical data supports its use in treating brittle nails (onychoschizia) and thinning hair.
2.Metabolic Enzyme Cofactor
• Mechanism: Acts as a prosthetic group for Acetyl-CoA carboxylase and Pyruvate carboxylase.
• Action: Facilitates the conversion of food into energy (ATP). Essential for maintaining healthy blood sugar levels and lipid metabolism.
3.Animal Health (Hoof & Coat)
• Mechanism: Promotes the synthesis of intercellular cementing substance in the hoof horn.
• Action: In horses and dairy cattle, Biotin supplementation significantly reduces hoof cracking and improves milk yield.
Applications
1.Nutraceuticals & Dietary Supplements
• Application: "Beauty from Within" gummies, capsules, and tablets.
• Why it works: High consumer awareness. It is the #1 ingredient sought after for hair growth and nail strengthening claims.
2.Animal Feed Additives
• Application: Premixes for Poultry, Swine, and Equine.
• Why it works: Prevents Fatty Liver and Kidney Syndrome (FLKS) in poultry and improves hoof hardness in livestock. (Typically used as Biotin 2%).
3.Cosmetics & Personal Care
• Application: Shampoos and conditioners.
• Why it works: While absorption via hair shafts is limited, it is a standard "hero ingredient" for strengthening claims in marketing.
Flow Chart
1.Synthesis: Chemical synthesis starting from Fumaric Acid or Tetronic Acid derivatives.
2.Cyclization: Formation of the imidazolidine ring structure.
3.Hydrolysis & Purification: Removal of isomers and by-products.
4.Crystallization: Formation of D-Biotin crystals (the biologically active isomer).
5.Filtration & Washing: Achieving high purity (>98.5%).
6.Drying: Vacuum drying.
7.Sieving / Trituration:
• For Pure: Sieved to fine powder.
• For Feed: Blended with carrier (Maltodextrin/Corn Starch) to create 1% or 2% concentration.
8.Packaging: 1kg Tins (Pure) or 25kg Bags (Feed Grade).
Quality Standard of Lactoferrin
Product: D-Biotin (USP / EP / Food Grade)
CAS: 58-85-5
| Item | Specification | Result |
| Appearance | White crystalline powder | Conforms |
| Assay (Titration) | 98.5% - 100.5% | 99.4% |
| Specific Rotation | +89° to +93° | +91.5° |
| Loss on Drying | ≤ 1.0% | 0.2% |
| Heavy Metals | ≤ 10 ppm | < 5 ppm |
| Lead (Pb) | ≤ 2 ppm | < 0.5 ppm |
| Arsenic (As) | ≤ 3 ppm | < 1 ppm |
| Organic Volatile Impurities | Meets USP Requirements | Conforms |
Method of Analysis of Lactoferrin
Test Method: Titration (USP)
• Procedure: Dissolve sample in water, add phenolphthalein indicator, and titrate with 0.1 N Sodium Hydroxide.
• Identification: IR Spectrum matching reference standard.
• Chirality: Specific Optical Rotation is critical to ensure it is the D-isomer (biologically active), as L-Biotin is inactive.
Reference Chromatogram of Lactoferrin Reference Substance
(Note: HPLC is also used for impurity profiling)
The HPLC chromatogram for D-Biotin shows a single major peak. Impurities from synthesis (like bis-biotin) should be negligible. The specific rotation test is the primary confirmation of stereochemical purity.
Stability and Safety
Stability Studies
• Thermal Stability: Excellent. Can withstand pelleting temperatures in feed mills.
• pH Sensitivity: Stable in acidic and neutral solutions; unstable in alkaline conditions.
• Shelf Life: 36 Months (3 Years) when stored properly.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous. GRAS (Generally Recognized As Safe).
• Handling: Avoid dust generation. Standard PPE.
• Storage: Store in tight containers. Light resistant.
Customer Comments
Nutritionist, EquiFeed Pro (UK)
2026.03.31
★★★★☆
Purchasing Manager, VitaGlow (USA)
2026.03.31
★★★★☆
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FAQ
Do you sell Biotin 1% or 2%?
Yes, we supply D-Biotin Pure (>98%) as well as 1% and 2% Triturations on Maltodextrin or Calcium Carbonate carriers, specifically designed for easy mixing in feed and food applications.
Is synthetic Biotin as effective as natural?
Yes. Our D-Biotin is chemically identical to the biotin found in nature. It has full biological activity and is the standard form used globally in medicine and nutrition.
What is the solubility?
Pure Biotin has low solubility in cold water but dissolves better in hot water or weak alkali solutions. Our 1% triturations are designed to disperse well in dry blends.
References
1.Mock, D.M. (2017). "Biotin: From Nutrition to Therapeutics." Journal of Nutrition.
2.Colombo, V.E., et al. (1990). "Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy." Journal of the American Academy of Dermatology.
3.EFSA Panel on Additives and Products or Substances used in Animal Feed. "Scientific Opinion on the safety and efficacy of biotin."
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