GHK-Cu
GHK-Cu Manufacturer | Blue Copper Peptide for Skin Repair (CAS: 49557-75-7) Source: Synthetic Peptide (Solid Phase Synthesis) | Purity: $\ge$ 98.0% (HPLC) | Certifications: ISO9001, COSMOS Approved (Raw Material) USP: High Purity Blue Crystal | Proven Wound Healing Efficacy | Ready Stock in Local Warehouse
Introduction
GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper; CAS: 49557-75-7) is a naturally occurring copper complex of the tripeptide GHK. First isolated from human plasma, it is characterized by its distinct deep blue color and profound biological activity.
Known as the "Holy Grail" of skin repair, GHK-Cu functions as a potent signaling peptide. It declines with age, which correlates with reduced tissue regeneration. By topically replenishing GHK-Cu, formulations can significantly accelerate wound healing, stimulate collagen production, and improve skin remodeling, making it a cornerstone ingredient in high-end anti-aging and post-procedure skincare.
Category：
Keywords：
peptide
healing
Functions
1 Skin Remodeling & Anti-Aging
GHK-Cu stimulates the synthesis of Collagen (Type I and III), elastin, and glycosaminoglycans (GAGs). Unlike harsh acids that strip the skin, GHK-Cu rebuilds the skin's structural matrix, reducing wrinkle depth and improving firmness and elasticity.
2.Wound Healing & Tissue Repair
It accelerates the wound healing process by promoting angiogenesis (new blood vessel formation) and nerve outgrowth. It is widely used in post-laser and post-microneedling recovery creams to reduce downtime and prevent scarring.
3.Anti-Inflammatory & Antioxidant
GHK-Cu suppresses the expression of pro-inflammatory cytokines (TNF-$\alpha$, IL-6) and inactivates free radicals. This dual action soothes irritated skin and protects cellular DNA from UV-induced damage.
Applications
Cosmetics:
• Anti-Aging Serums: The "Blue Copper" serums targeting fine lines and sagging skin.
• Repair Creams: Formulas for sensitive skin or post-dermatological procedures (laser, peels).
• Hair Care: Promotes hair growth by enlarging hair follicles and prolonging the anagen phase (often compared to Minoxidil efficacy in studies).
Medical Devices:
• Incorporated into wound dressings and hydrogels for diabetic ulcers and burn treatment.
Flow Chart
Our peptide synthesis ensures high yield and successful copper complexation:
1.Peptide Synthesis: Solid-Phase Peptide Synthesis (SPPS) of the GHK tripeptide (Gly-His-Lys).
2.Cleavage & Purification: Cleaving the peptide from the resin and purifying via Preparative HPLC.
3.Complexation: Reacting pure GHK with Copper (II) ions (typically Copper Acetate or Chloride) under controlled pH.
4.Purification: Removal of unbound copper and salts.
5.Lyophilization: Freeze-drying to produce the stable blue powder.
6.QC Testing: Verifying copper content and peptide purity.
Quality Standard of Lactoferrin
Product: GHK-Cu (Cosmetic Grade)
CAS No.: 49557-75-7
| Item | Specification | Result |
| Appearance | Blue to violet fine powder | Conforms |
| Peptide Purity (HPLC) | $\ge$ 98.0% | 99.2% |
| Copper Content (Cu) | 8.0% – 15.0% (Depends on salt form) | 10.5% |
| Water Content (Karl Fischer) | $\le$ 8.0% | 4.2% |
| Acetate Content | $\le$ 15.0% | 8.5% |
| pH (1% Solution) | 5.5 – 7.5 | 6.2 |
| Amino Acid Composition | ± 10% of theoretical | Conforms |
| MS (Mass Spectrometry) | 340.5 ± 1.0 (GHK) / 403 ± 1 (GHK-Cu) | Conforms |
| Microbiology | < 100 CFU/g | Conforms |
Method of Analysis of Lactoferrin
• HPLC: Determines the purity of the GHK peptide backbone and detects any synthesis by-products (deletion sequences).
• Atomic Absorption Spectroscopy (AAS): Precisely quantifies the Copper ion content to ensure specific stoichiometry (1:1 complex).
• Mass Spec: Confirms molecular weight identity.
Reference Chromatogram of Lactoferrin Reference Substance
The HPLC profile shows a single sharp peak. We strictly control the level of free GHK (uncomplexed peptide) and free Copper ions, ensuring the product is the fully chelated GHK-Cu complex for maximum stability and efficacy.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Storage Conditions: GHK-Cu is hygroscopic and light-sensitive.
• Data: Stable at room temperature for short periods, but for long-term storage, 2-8°C (Refrigerated) in dark, sealed containers is recommended to prevent oxidation and color fading.
• Formulation Note: Avoid using with strong chelating agents (EDTA) or high concentrations of Vitamin C, as they can dissociate the copper from the peptide.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous.
• Skin Compatibility: Excellent. Low irritation potential.
• Handling: Wear gloves to prevent staining skin blue.
• Storage: Keep refrigerated. Protect from light and moisture.
Customer Comments
Product Manager, Indie Beauty Brand, USA
2026.03.31
★★★★☆
R&D Director, Derma-Cosmetic Lab, France
2026.03.31
★★★★☆
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Exhibitions
Meet Manager Liu Zhenhua and our team at:
• In-Cosmetics Global (Paris/London)
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FAQ
What is the recommended percentage in formulations?
For general anti-aging, 0.05% - 0.2% is effective. For intensive repair or post-procedure products, concentrations up to 0.5% - 1.0% are used. Solutions will appear light blue to deep blue depending on concentration.
Can I mix GHK-Cu with Vitamin C or Retinol?
It is generally not recommended to mix GHK-Cu directly with L-Ascorbic Acid (Vitamin C) or strong acids, as they can break the copper bond. Use them at different times of the day (e.g., Vitamin C in AM, GHK-Cu in PM). Retinol is generally compatible if pH is balanced.
Why is the powder blue?
The blue color is characteristic of the Copper (II) ion complexed with the peptide. If the powder is white, it is likely just the GHK peptide without copper, which lacks the specific wound-healing properties of the complex.
References
1.Pickart, L., et al. (2008). "The human tripeptide GHK and tissue remodeling." Journal of Biomaterials Science.
2.Borkow, G., et al. (2010). "Copper, an essential micronutrient for human skin regeneration." Cosmetics & Toiletries.
3.Pickart, L., et al. (2018). "GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration." BioMed Research International.
4.Maquart, F.X., et al. (1993). "Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex GHK-Cu." FEBS Letters.
5.Finkley, M.B., et al. (2005). "Copper peptide GHK-Cu stimulates nerve regeneration." Wound Repair and Regeneration.
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