Pterostilbene Powder
Pterostilbene Manufacturer | "Next-Gen Resveratrol" (CAS: 537-42-8) Source: Vaccinium spp. (Blueberry) / Synthetic | Purity: 99% (HPLC) | Certifications: ISO9001, Kosher, Halal, Non-GMO USP: 4x Higher Bioavailability than Resveratrol | Superior Stability | Ready Stock in US/EU
Introduction
Pterostilbene (CAS: 537-42-8; Chemical Name: trans-3,5-dimethoxy-4-hydroxystilbene) is a naturally occurring dimethylated analog of Resveratrol, primarily found in blueberries and pterocarpus heartwood. Often hailed as the "Second Generation Resveratrol," it overcomes the major limitations of its predecessor.
Due to the substitution of two hydroxyl groups with methoxy groups, Pterostilbene is highly lipophilic, allowing it to penetrate cell membranes and cross the blood-brain barrier significantly more effectively than Resveratrol. It is a premium ingredient for advanced anti-aging, cognitive health, and metabolic support formulations.
Category：
Keywords：
resveratrol
pterostilbene
Functions
1.Superior Bioavailability (PK Profile)
Pterostilbene exhibits a plasma concentration 36 times higher than Resveratrol after oral administration. Its methoxylated structure prevents rapid glucuronidation in the liver, extending its biological half-life (approx. 105 mins vs. 14 mins for Resveratrol).
2.Cognitive Health & Neuroprotection
By crossing the blood-brain barrier, it modulates neural plasticity and reduces oxidative stress in the hippocampus. Studies suggest it improves memory function and neuro-protection against age-related decline.
3.Potent Antioxidant & Anti-Inflammatory
It activates the Nrf2 pathway, boosting the body's endogenous antioxidant defense. It also inhibits the expression of COX-2 and iNOS, providing robust anti-inflammatory support for joint and cardiovascular health.
Applications
• Dietary Supplements: High-end "Longevity" and "Nootropic" capsules. Often paired with NAD+ precursors (like NMN/NR) for synergistic anti-aging effects.
• Cosmetics: A powerful skin brightener. It inhibits tyrosinase activity more effectively than Kojic Acid and protects against UV-induced damage (photoaging).
• Functional Foods: Suitable for lipid-based delivery systems (softgels, emulsions) due to its high oil solubility.
Flow Chart
Our synthesis route (for 99% purity) ensures commercial scalability and environmental compliance:
1.Condensation: Reaction of 3,5-dimethoxybenzaldehyde with 4-hydroxyphenylacetic acid.
2.Decarboxylation: Catalytic conversion under controlled heating.
3.Crude Crystallization: Isolation of the trans-stilbene structure.
4.Recrystallization: Purification using ethanol/water to remove cis-isomers and impurities.
5.Centrifugation & Washing: Removal of residual solvents.
6.Vacuum Drying: Low-temperature drying to preserve stability.
7.Micronization: Milling to uniform particle size (optional).
Quality Standard of Lactoferrin
Product: Pterostilbene 99%
CAS No.: 537-42-8
| Item | Specification | Result |
| Appearance | White to off-white crystalline powder | Conforms |
| Assay (HPLC) | 99.0% | 99.4% |
| Melting Point | 144°C – 148°C | 145.2°C |
| Loss on Drying | 0.5% | 0.12% |
| Residue on Ignition | 0.1% | 0.04% |
| Heavy Metals (Pb) | 10 ppm | < 5 ppm |
| Arsenic (As) | 2 ppm | < 0.5 ppm |
| Total Plate Count | < 1000 CFU/g | Conforms |
| Solubility | Soluble in Ethanol, DMSO; Lipophilic | Conforms |
Method of Analysis of Lactoferrin
• HPLC Condition:
○ Column: C18 Reverse Phase
○ Mobile Phase: Acetonitrile : Water (0.1% Phosphoric Acid)
○ Detector: UV at 306 nm
• Isomer Control: The method specifically separates the bioactive trans-Pterostilbene from the inactive cis-isomer and other stilbene impurities.
Reference Chromatogram of Lactoferrin Reference Substance
The chromatogram displays a single, sharp peak at the retention time of trans-Pterostilbene (~12.5 min). No significant interference from synthesis by-products (like Resveratrol or methylated impurities) is observed, confirming >99% purity.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Advantages: Unlike Resveratrol, which is light-sensitive and prone to oxidation (turning pink/brown), Pterostilbene is chemically more stable due to the methoxy protection.
• Data: Samples stored at 25°C/60% RH maintained 98.8% assay after 24 months.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous.
• GRAS Status: Generally Recognized As Safe (GRAS) in the US for specific food uses (up to 30mg/serving).
• Storage: Store in a cool, dry place. Protect from strong light, although it is more stable than Resveratrol.
Customer Comments
R&D Director, Longevity Supplement Brand, USA
2026.03.31
★★★★☆
QC Manager, Contract Manufacturer, Canada
2026.03.31
★★★★☆
Our Certificates
SKS-Kosher
CERTIFICATE
CERTIFICATE
ISO9001
ISO22000
FDA
Our Clients
Exhibitions
Meet Manager Jin Xinli and our team at:
• SupplySide West (Las Vegas)
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• In-Cosmetics Global
FIC Shanghai
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SupplySide West (Las Vegas)
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CPHI & PMEC 2024
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CPHI 2025
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CPHI 2023
FIC 2022
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CPhI Worldwide
FAQ
Why choose Pterostilbene over Resveratrol?
Pterostilbene is "Resveratrol 2.0." It has 4x better absorption, a 7x longer half-life, and crosses the blood-brain barrier effectively. It provides similar benefits (SIRT1 activation) but at a much lower effective dose.
Is your Pterostilbene natural or synthetic?
We primarily offer Nature-Identical Synthetic Pterostilbene (High Purity >99%). Extracting this purity from blueberries is commercially unviable (yield is extremely low). Our synthetic route ensures purity, consistency, and affordability while being chemically identical to the molecule found in nature.
What is the recommended dosage?
Typical supplement dosages range from 50 mg to 150 mg per day. For cognitive support, it is often dosed at the higher end of this range.
References
1.Kapetanovic, I.M., et al. (2011). "Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats." Cancer Chemotherapy and Pharmacology.
2.Rimando, A.M., et al. (2002). "Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol." Journal of Agricultural and Food Chemistry.
3.Chang, J., et al. (2012). "Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease." Neurobiology of Aging.
4.Remsberg, C.M., et al. (2008). "Pharmacometrics of pterostilbene: preclinical pharmacokinetics and metabolism." Phytotherapy Research.
5.McCormack, D., et al. (2013). "Pterostilbene, a potent antioxidant and anti-inflammatory agent." Oxidative Medicine and Cellular Longevity.
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