N-Acetyl-D-Glucosamine
N-Acetyl-D-Glucosamine Manufacturer | HA Precursor & Skin Whitening (CAS: 7512-17-6) Headline: N-Acetyl-D-Glucosamine (NAG) Powder | The Hyaluronic Acid Booster Sub-info: Assay ≥ 98.0% | Fermented (Vegan) & Shellfish Sources Available | Cosmetic & Food Grade. USP: • Hyaluronic Acid Precursor: A direct building block for the synthesis of Hyaluronic Acid (HA) in the skin and joints. • Skin Whitening: Clinically proven to inhibit melanin production and exfoliate gently, offering a natural alternative to acid peels. • High Stability: More stable and neutral pH compared to Glucosamine HCl, making it ideal for creams and serums.
Introduction
N-Acetyl-D-Glucosamine (NAG, CAS: 7512-17-6) is an amide derivative of the monosaccharide glucose. It is a fundamental component of structural polymers in the body, including Hyaluronic Acid and Keratan Sulfate.
Unlike regular Glucosamine (which is acidic and often irritating in topical use), NAG has a neutral pH and excellent transdermal absorption. This makes it a star ingredient in Cosmeceuticals for hydration and whitening. We offer both Shellfish-derived (Traditional) and Bio-fermented (Vegan) grades to meet the diverse needs of the Global Personal Care and Nutraceutical markets.
Category：
Keywords：
acid
hyaluronic
Functions
1.Hyaluronic Acid Synthesis (Hydration)
NAG stimulates the production of Hyaluronic Acid by fibroblasts and keratinocytes. By providing the essential substrate, it enhances skin hydration from within, reducing fine lines and improving elasticity.
2.Skin Whitening & Exfoliation
NAG inhibits the glycosylation of tyrosinase (the enzyme that produces melanin), thereby reducing dark spots and hyperpigmentation. It also helps normalize the exfoliation of the stratum corneum, leaving skin smoother and brighter without the irritation of AHAs.
3.Joint & Gut Health
Oral NAG is a precursor for glycosaminoglycans (GAGs) in cartilage. It also helps repair the protective mucin layer in the digestive tract, supporting gut barrier integrity (Leaky Gut).
Applications
1.Cosmetics & Skincare (Focus)
• Products: Anti-aging creams, Whitening serums, Moisturizers.
• Synergy: Often combined with Niacinamide (Vitamin B3). Studies show that NAG + Niacinamide works synergistically to reduce hyperpigmentation more effectively than either ingredient alone.
2.Dietary Supplements
• Products: Joint support capsules, Gut health powders.
• Benefit: A unique form of glucosamine that is well-tolerated and supports the mucosal lining.
3.Medical Aesthetics
• Usage: As a raw material for producing cross-linked Hyaluronic Acid fillers.
Flow Chart
Enzymatic Hydrolysis or Fermentation
1.Method A (Shellfish): Chitin $\rightarrow$ Acid Hydrolysis $\rightarrow$ N-Acetylation $\rightarrow$ Refining.
2.Method B (Vegan): Glucose + Corn Steep Liquor $\rightarrow$ Microbial Fermentation $\rightarrow$ Extraction.
3.Purification: Ion exchange chromatography to remove impurities.
4.Crystallization: Concentration and cooling.
5.Drying: Vacuum drying.
6.Milling: Pulverizing to 80 Mesh.
7.QC Testing: HPLC Assay, pH, Specific Rotation.
8.Packing: 25kg Drums.
Quality Standard of Lactoferrin
Product: N-Acetyl-D-Glucosamine (Cosmetic Grade)
| Item | Specification | Result |
| Appearance | White crystalline powder | Conforms |
| Odor | Odorless | Conforms |
| Assay (HPLC) | ≥ 98.0% | 99.2% |
| pH (2% Solution) | 6.0 ~ 8.0 | 6.8 |
| Specific Rotation | +39.0° ~ +43.0° | +41.5° |
| Loss on Drying | ≤ 0.5% | 0.2% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Heavy Metals (Pb) | ≤ 10 ppm | Conforms |
| Arsenic (As) | ≤ 1.0 ppm | Conforms |
| Solubility | Soluble in water | Conforms |
| Total Plate Count | < 100 cfu/g | < 10 cfu/g |
Method of Analysis of Lactoferrin
HPLC (High-Performance Liquid Chromatography)
• Why: To distinguish NAG from free Glucosamine and ensure the acetylation is complete. The assay is critical for efficacy in whitening formulations.
Reference Chromatogram of Lactoferrin Reference Substance
The HPLC chromatogram shows a single peak corresponding to N-Acetyl-D-Glucosamine. The absence of a Glucosamine peak confirms complete reaction and high purity.
Stability and Safety
Stability Studies
• pH Stability: NAG is stable at a wide pH range (5-8), unlike Glucosamine HCl which degrades in alkaline conditions.
• Heat Stability: Stable up to 80°C, suitable for hot processing in cosmetic emulsions.
• Shelf Life: 24 months.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous.
• Skin Tolerance: Excellent. Non-irritating even at high concentrations (up to 10%).
• Handling: Standard hygiene.
• Storage: Cool, dry place.
Customer Comments
Formulator, Clean Beauty Brand (USA)
2026.03.24
★★★★☆
Product Manager, Supplement Co. (Australia)
2026.03.24
★★★★☆
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FAQ
What is the main difference between Glucosamine and N-Acetyl Glucosamine?
• Glucosamine (HCl/Sulfate): Acidic, salt form, mainly for oral joint supplements. • NAG: Neutral, non-salt form, better for skin absorption and hyaluronic acid synthesis. It is the preferred form for cosmetics.
Is it vegan?
We offer two types: 1.Shellfish Source: Traditional, lower cost. 2.Fermentation Source: 100% Vegan, derived from corn fermentation. Ideal for "Clean Beauty" brands.
Can I use it with Retinol or Vitamin C?
Yes. NAG is very gentle and stable. It pairs well with Retinol (reducing irritation) and Vitamin C (boosting brightness) without conflict.
References
1.Bissett, D. L., et al. (2007). N-acetyl glucosamine: a new cosmetic ingredient with skin moisturizing and cell turnover properties. Journal of Cosmetic Dermatology.
2.Kimball, A. B., et al. (2010). Reduction in the appearance of facial hyperpigmentation after use of a moisturizer with a combination of topical niacinamide and N-acetyl glucosamine. British Journal of Dermatology.
3.Salvatore, S., et al. (2000). A pilot study of N-acetyl glucosamine, a nutritional substrate for glycosaminoglycan synthesis. Clinical Therapeutics.
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