Alpha-GPC
Alpha-GPC Manufacturer | Premium Nootropic Choline (CAS: 28319-77-9) Headline: L-Alpha-Glycerylphosphorylcholine (Alpha-GPC) | The Bio-Active Choline for Cognitive Performance Sub-info: Assay 99% (Pure) & 50% (Anti-Caking Grade) | Soy-Derived or Synthetic | Non-GMO & Vegan. USP: • Superior Bioavailability: Crosses the blood-brain barrier more efficiently than Choline Bitartrate or Citicoline. • Dual Action: Enhances cognitive function (Acetylcholine synthesis) and supports physical power output (Growth Hormone secretion). • Formulation Friendly: We offer a stabilized 50% Powder specifically designed to solve the clumping/deliquescence issues common with Alpha-GPC.
Introduction
Alpha-GPC (L-Alpha-Glycerylphosphorylcholine, CAS: 28319-77-9) is a natural physiological precursor to Acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. It naturally occurs in the brain and in small amounts in milk and soy.
As a Nootropic, Alpha-GPC is revered for its ability to rapidly deliver choline to the brain. Unlike other choline sources, it is water-soluble and crosses the blood-brain barrier with ease. We manufacture high-quality Alpha-GPC suitable for Cognitive Supplements, Pre-Workout Formulas, and Functional Beverages. Due to the extreme hygroscopicity of the pure material, we specialize in providing moisture-resistant grades (50%) for hassle-free manufacturing.
Category：
Keywords：
cognitive
crosses
Functions
1．Cognitive Enhancement (Memory & Focus)
Alpha-GPC increases the synthesis and release of Acetylcholine in the hippocampus. Clinical studies suggest it supports memory recall, learning ability, and focus, making it a staple in "Brain Health" stacks and formulas for age-related cognitive decline.
2．Athletic Performance (Power & HGH)
It is widely used in sports nutrition to boost anaerobic power output (explosive strength). Additionally, research indicates that Alpha-GPC supplementation prior to exercise can potentiate the exercise-induced response of Growth Hormone (HGH), aiding in recovery and muscle maintenance.
3.Neuroprotection
It supports the integrity of neuronal membranes (phospholipids), potentially protecting brain cells from damage and supporting recovery after ischemic events.
Applications
1.Nootropic Capsules
• Recommended Grade: Alpha-GPC 50% Powder or 85% Liquid (for softgels).
• Benefit: Improves mental clarity and focus ("Flow State").
• Formulation Note: If using 99% powder in capsules, strict humidity control (<30% RH) in the production room is required.
2.Pre-Workout Powders
• Recommended Grade: Alpha-GPC 50% (Stabilized with Silicon Dioxide/Calcium Phosphate).
• Benefit: Connects mind and muscle; boosts explosive power.
• Why 50%? It prevents the tub of powder from turning into a sticky brick after opening.
3.Functional Beverages
• Recommended Grade: Alpha-GPC 99% (High Purity).
• Benefit: Odorless and tasteless, dissolves instantly in water for energy drinks or focus shots.
Flow Chart
Enzymatic Conversion or Chemical Synthesis
1.Route A (Natural): Phosphatidylcholine (from Non-GMO Soy Lecithin) $\rightarrow$ Enzymatic Deacylation $\rightarrow$ Purification.
2.Route B (Synthetic): Reaction of GPC precursors $\rightarrow$ Purification.
3.Refining: Ion-exchange chromatography to remove impurities and free fatty acids.
4.Concentration: Vacuum evaporation.
5.Stabilization (Crucial Step):
• For 99%: Direct crystallization and drying (Requires strict moisture control).
• For 50%: Spray drying with carriers (e.g., Silicon Dioxide, Dicalcium Phosphate, or Maltodextrin) to reduce hygroscopicity.
6.Sieving: Passing 40-80 Mesh.
7.QC Testing: HPLC Assay, Specific Rotation, Moisture.
8.Packing: Double PE bags in Drums (with extra desiccant).
Quality Standard of Lactoferrin
Product: Alpha-GPC 50% Powder (Stabilized Grade)
| Item | Specification | Result |
| Appearance | White free-flowing powder | Conforms |
| Alpha-GPC Content (HPLC) | ≥ 50.0% | 51.2% |
| Carrier | Silicon Dioxide / Calcium Phosphate | Conforms |
| Loss on Drying | ≤ 5.0% | 3.5% |
| Specific Rotation | -2.4° ~ -2.8° | -2.6° |
| pH (10% Solution) | 5.0 ~ 7.0 | 6.2 |
| Heavy Metals (Pb) | ≤ 10 ppm | Conforms |
| Arsenic (As) | ≤ 1.0 ppm | Conforms |
| Residual Solvents | Ethanol < 5000 ppm | < 50 ppm |
| Total Plate Count | < 1000 cfu/g | < 100 cfu/g |
(Note: We also supply Alpha-GPC 99% Pure Powder and 85% Liquid.)
Method of Analysis of Lactoferrin
HPLC & Specific Rotation
• HPLC: Used to determine the exact content of L-Alpha-Glycerylphosphorylcholine.
• Specific Rotation: Critical to confirm it is the biologically active L-isomer (Levorotatory). Synthetic racemic mixtures (DL-GPC) are less effective and cheaper. Our product is pure L-Alpha-GPC.
Reference Chromatogram of Lactoferrin Reference Substance
The HPLC chromatogram shows a single sharp peak for Alpha-GPC. For the 50% grade, the carrier material (SiO2) is inert and does not interfere with the assay peak but is visible as insoluble matter if dissolved in certain solvents.
Stability and Safety
Stability Studies
• Hygroscopicity: EXTREME. Pure Alpha-GPC (99%) will absorb moisture from the air and turn into a gel/liquid within minutes if left open.
• Solution: We strongly recommend the 50% Grade for powder blends.
• Storage: Must be stored in original sealed containers with desiccant. Once opened, use immediately.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance. GRAS.
• Handling: Wear gloves and mask. Avoid exposing 99% powder to humid air.
• Storage: Cool, dry place. Tightly sealed.
Customer Comments
Production Manager, Sports Nutrition Co. (USA)
2026.03.21
★★★★☆
R&D Director, Functional Beverage Brand (Korea)
2026.03.21
★★★★☆
Our Certificates
CERTIFICATE
CERTIFICATE
FDA
ISO
HALAL
HACCP
Our Clients
Exhibitions
• SupplySide West (Las Vegas)
• Vitafoods Europe (Geneva)
• Natural Products Expo West (Anaheim)
FIC 2022
Vitafoods Europe (Geneva)
SupplySide West (Las Vegas)
CPHI 2025
CPHI 2024
CPHI 2023
CAC 24th
CPhI Worldwide
In-Cosmetics Global
CAC Shanghai
CPHI & PMEC 2024
FIC Shanghai
CPHI & PMEC China Shanghai
CPHI & PMEC China 2025
SupplySide West (Las Vegas)
FIC 2023
FIC2024
CPHI Korea
SupplySideWEST Las Vegas
SupplySideWEST 2023
Vitafoods Europe Switzerland
Wagri Guangzhou
FAQ
Why does Alpha-GPC turn into liquid?
Alpha-GPC is highly hygroscopic (loves water). At 99% purity, it pulls moisture from the air rapidly. This is a sign of purity, not a defect. For easier handling, use our 50% grade or handle 99% in a dehumidified room.
Which is better: Alpha-GPC or Citicoline (CDP-Choline)?
• Alpha-GPC: Higher choline content by weight (~40%) and better blood-brain barrier penetration. Often preferred for physical power and acute focus. • Citicoline: Lower choline content (~18%) but also provides Uridine. • Alpha-GPC is generally considered more cost-effective for pure choline delivery.
Is your product Soy-Free?
Standard Alpha-GPC is often derived from Soy Lecithin. However, we also offer Sunflower-derived or Synthetic options for clients requiring a "Soy-Free" allergen label.
References
1.Parker, A. G., et al. (2015). The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. Journal of the International Society of Sports Nutrition.
2.De Jesus, S. (2003). Alpha-glycerylphosphorylcholine in the mental recovery of cerebral ischemic attacks. Annals of the New York Academy of Sciences.
3.Ziegenfuss, T., et al. (2008). Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. Journal of the International Society of Sports Nutrition.
Our Global Presence：Pioneer Biotech | Pioneer Bio Inc. | Kono Chem | Kono Chem (RU)
P&K INTERNATIONAL PTE. LTD.