Astragaloside IV
Astragaloside IV Manufacturer | 98% Telomere Support Ingredient (CAS: 83207-58-3) Headline: Astragaloside IV Powder | The Potent Saponin for Anti-Aging & Heart Health Sub-info: Assay ≥ 98.0% (HPLC) | Extracted from Astragalus membranaceus Root | Telomerase Activator. USP: • Telomere Protection: Scientifically recognized as a natural telomerase activator, slowing down cellular aging. • Cardioprotection: Improves cardiac function and protects against ischemic injury (widely used in TCM modern drugs). • High Purity: We utilize specialized purification technology to isolate Astragaloside IV to 98% purity, free from other saponins.
Introduction
Astragaloside IV (CAS: 83207-58-3) is the primary biologically active saponin (cycloartane-type triterpene glycoside) found in the root of Astragalus membranaceus (Huang Qi). While raw Astragalus root contains only trace amounts (approx. 0.04%), our advanced extraction process concentrates this precious molecule to pharmaceutical purity levels.
It is distinct from Astragalus Polysaccharides (immune support). Astragaloside IV is the specific marker compound responsible for the herb's deep restorative, anti-inflammatory, and anti-aging properties. We offer specifications ranging from 1% to 98%, with the 98% grade being the premier choice for high-end longevity supplements and cardiovascular formulations.
Category：
Keywords：
stigmasterol
phytosterol
deodorizer
Functions
1.Telomerase Activation (Anti-Aging)
Research suggests Astragaloside IV acts as a mild telomerase activator. By helping to maintain telomere length, it delays replicative senescence in cells, making it a star ingredient in the "Life Extension" and longevity market.
2.Cardiovascular Health
It exerts a positive inotropic effect (improving heart contraction strength) without increasing heart rate. It also protects cardiomyocytes from ischemia-reperfusion injury, supporting recovery after cardiovascular events.
3.Immune & Anti-Inflammatory
Unlike non-specific immune boosters, Astragaloside IV modulates the immune response by inhibiting the NF-κB signaling pathway, reducing chronic inflammation (inflammaging) and protecting lung and kidney tissues.
Applications
1.Longevity Supplements
• Products: Telomere support capsules, NMN synergistic stacks.
• Benefit: Positioned as a "Telomere Defender." The 98% purity allows for small, potent dosages (e.g., 50mg).
2.Pharmaceutical Preparations
• Products: Heart failure medications, Diabetic nephropathy treatments.
• Benefit: Its ability to improve microcirculation and reduce endothelial damage makes it a valuable API candidate.
3.High-End Skincare
• Products: Anti-wrinkle serums, Repair creams.
• Benefit: Promotes collagen synthesis and protects skin stem cells from UV damage.
Flow Chart
Purification from Trace to 98%
1.Raw Material: Premium Astragalus Root (GAP Cultivation, 5-year roots preferred).
2.Extraction: Ethanol reflux extraction.
3.Column Chromatography: Separation of total saponins (Astragalosides) from polysaccharides.
4.Purification: Using Macroporous Resin to enrich Astragaloside IV.
5.Crystallization: Repeated crystallization in specific solvents to achieve 98% purity.
6.Drying: Vacuum drying.
7.Milling: Pulverizing to fine white powder.
8.QC Testing: HPLC Assay (ELSD Detector) & Residual Solvents.
9.Packing: 1kg Aluminum Foil Bags / 25kg Drums.
Quality Standard of Lactoferrin
Product: Astragaloside IV 98% (Pharma/Food Grade)
| Item | Specification | Result |
| Appearance | White fine powder | Conforms |
| Assay (HPLC-ELSD) | ≥ 98.0% | 98.4% |
| Melting Point | 295°C ~ 296°C | 295.5°C |
| Specific Rotation | +20.0° ~ +24.0° | +22.1° |
| Loss on Drying | ≤ 2.0% | 1.1% |
| Ash | ≤ 0.5% | 0.1% |
| Heavy Metals (Pb) | ≤ 10 ppm | Conforms |
| Arsenic (As) | ≤ 2.0 ppm | Conforms |
| Pesticide Residues | USP/EP Compliant | Conforms |
| Solvent Residue | ≤ 5000 ppm (Ethanol) | < 100 ppm |
Method of Analysis of Lactoferrin
HPLC-ELSD (Evaporative Light Scattering Detector)
• Why: Astragaloside IV has weak UV absorption (only terminal absorption), making standard UV detection inaccurate.
• Our Method: We use ELSD or CAD (Charged Aerosol Detector) coupled with HPLC. This is the only reliable method to accurately quantify high-purity Astragaloside IV and detect impurities.
Reference Chromatogram of Lactoferrin Reference Substance
The HPLC-ELSD chromatogram displays a single, symmetrical peak at the retention time of the Astragaloside IV standard. The baseline is flat, confirming the removal of other interfering saponins (like Astragaloside I, II, III).
Stability and Safety
Stability Studies
• Hygroscopicity: The pure powder is slightly hygroscopic.
• Storage: Must be kept in a desiccated, airtight container.
• Shelf Life: 24 months when stored at room temperature (< 25°C) away from light.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance.
• Toxicity: Very low toxicity. Safe for long-term consumption at recommended doses.
• Handling: Standard lab hygiene.
• Storage: Cool, dry place.
Customer Comments
Purchasing Manager, Biotech Company (USA)
2026.03.21
★★★★☆
Formulator, Cosmetic Brand (France)
2026.03.21
★★★★☆
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FAQ
Why is Astragaloside IV so expensive compared to Astragalus Extract?
The content of Astragaloside IV in the raw root is extremely low (0.04%). It takes over 2,500 kg of dried root to produce just 1 kg of 98% Astragaloside IV. The extraction and purification costs are very high.
What is the recommended dosage?
For 98% purity, the typical dosage is low: 50mg - 100mg per day. (Compare this to standard Astragalus extracts where dosage is 500mg - 2000mg).
Can I test it with a UV detector?
No. You will not get an accurate result. Astragaloside IV does not have a chromophore. You must use HPLC-ELSD or HPLC-MS for accurate assay testing.
References
1.Ren, S., et al. (2013). Pharmacological effects of Astragaloside IV: a literature review. Journal of Traditional Chinese Medicine.
2.Zhang, J., et al. (2011). Astragaloside IV protects against ischemia-reperfusion in a murine model of thrombosis. Thrombosis Research.
3.Wang, Y., et al. (2009). The effect of astragaloside IV on telomerase activity in human fetal lung diploid fibroblast cells. Chinese Journal of Pharmacology.
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