Calcium L-Threonate
Calcium L-Threonate Manufacturer | Bone & Brain Dual Action (CAS: 70753-61-6) Headline: Calcium L-Threonate Powder | The Bio-Active Calcium for Osteoporosis (CAS: 70753-61-6) Sub-info: Assay ≥ 98.0% | L-Form Isomer | High Bioavailability | USP Grade. USP: • 95% Absorption Rate: Clinically demonstrated to have significantly higher passive absorption than Calcium Citrate or Carbonate, independent of Vitamin D. • Collagen Stimulation: Uniquely stimulates osteoblasts to synthesize Collagen Type I, building the "bone matrix" framework for calcium to deposit. • Brain Health: The only calcium form capable of crossing the Blood-Brain Barrier (BBB), supporting neuronal health and memory.
Introduction
Calcium L-Threonate (CAS: 70753-61-6) is a novel calcium salt of L-Threonic acid, a metabolite of Vitamin C. Unlike traditional calcium supplements that simply provide mineral mass, Calcium L-Threonate is a bio-active drug candidate for treating osteoporosis and osteopenia.
Our high-purity Calcium L-Threonate 98% acts as a specific "bone-seeking" nutrient. It does not just float in the blood; it actively targets the skeletal system to promote collagen formation and cartilage repair. It is odorless, tasteless, and highly soluble, making it the premium choice for high-end Bone Health Supplements and Functional Beverages.
Category：
Keywords：
calcium
l-threonate
Functions
1.Osteoblast Proliferation & Collagen Synthesis
Bones are made of a protein matrix (collagen) hardened by minerals. Calcium L-Threonate stimulates the uptake of Ascorbic Acid (Vitamin C) into bone cells, directly boosting the production of Type I Collagen and Mineralized Nodules. This rebuilds the bone's internal structure, not just its density.
2.High Bioavailability & Retention
It is absorbed through passive transport in the intestine, meaning it does not rely heavily on Vitamin D or stomach acid. This results in high plasma calcium levels without the risk of kidney stones or calcification of soft tissues often associated with Calcium Carbonate.
3.Cartilage Repair
Studies show it promotes the synthesis of chondrocytes (cartilage cells), improving joint flexibility and reducing pain in osteoarthritis patients.
4.Cognitive Function
By delivering L-Threonate across the blood-brain barrier, it helps increase synaptic density and plasticity, potentially improving learning and memory (similar to Magnesium L-Threonate).
Applications
1.Premium Bone Health Supplements
• Claim: "Reverses Bone Age," "Builds Bone Matrix."
• Format: Capsules, Tablets.
• Target: Post-menopausal women, Seniors with Osteoporosis.
2.Joint Care Formulas
• Synergy: Often combined with Glucosamine and Chondroitin.
• Benefit: Provides the structural minerals needed while Glucosamine provides the lubrication.
3.Functional Beverages
• Benefit: Fully water-soluble and flavorless.
• Usage: Fortified waters and senior nutrition drinks (RTD) where sediment/chalkiness of Calcium Carbonate is unacceptable.
Flow Chart
Vitamin C Metabolite Synthesis
1.Raw Material: L-Ascorbic Acid (Vitamin C) or Glucose.
2.Oxidation: Controlled catalytic oxidation to produce L-Threonic Acid.
3.Neutralization: Reaction with Calcium Hydroxide/Carbonate.
4.Crystallization: Forming Calcium L-Threonate crystals.
5.Purification: Recrystallization to remove isomers and impurities.
6.Centrifugation & Washing: Separating pure crystals.
7.Drying: Vacuum drying.
8.Milling: Pulverizing to 80 Mesh.
9.QC Testing: Calcium Content (Titration) & Optical Rotation.
10.Packing: 25kg Drums.
Quality Standard of Lactoferrin
Product: Calcium L-Threonate 98% (Food/Pharma Grade)
| Item | Specification | Result |
| Appearance | White crystalline powder | Conforms |
| Odor | Odorless | Conforms |
| Assay (on dried basis) | ≥ 98.0% | 99.1% |
| Calcium Content | 12.8% ~ 13.5% | 13.1% |
| Specific Rotation | +15.0° ~ +18.0° | +16.5° |
| pH (1% Solution) | 6.0 ~ 8.0 | 7.2 |
| Loss on Drying | ≤ 1.0% | 0.4% |
| Heavy Metals (Pb) | ≤ 10 ppm | Conforms |
| Arsenic (As) | ≤ 2.0 ppm | Conforms |
| Solubility | Soluble in water | Conforms |
| Total Plate Count | < 1000 cfu/g | < 100 cfu/g |
Method of Analysis of Lactoferrin
Complexometric Titration (EDTA)
• Calcium Content: We use EDTA titration to precisely measure the elemental calcium percentage (~13%).
• Optical Rotation: Essential to verify the L-Isomer configuration. Synthetic D-isomer or racemic mixtures do not possess the same biological activity.
Reference Chromatogram of Lactoferrin Reference Substance
The IR spectrum shows specific absorption bands for the carboxylate group and hydroxyl groups of the threonate moiety. The X-Ray Diffraction (XRD) pattern confirms the unique crystal lattice structure that confers its high solubility.
Stability and Safety
Stability Studies
• Stability: Very stable in dry powder form.
• Solution: Aqueous solutions are stable at neutral pH.
• Shelf Life: 36 months (3 Years).
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance.
• Safety: Safe and well-tolerated. Does not cause gas, bloating, or constipation like Calcium Carbonate.
• Handling: Standard hygiene.
• Storage: Cool, dry place.
Customer Comments
R&D Director, Orthopedic Pharma Co. (China)
2026.03.19
★★★★☆
Product Developer, Beverage Brand (USA)
2026.03.19
★★★★☆
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FAQ
How does it compare to Calcium Gluconate?
• Calcium Gluconate: Low calcium content (~9%), low absorption. Used mostly for IV injection or cheap tablets. • Calcium L-Threonate: Moderate calcium content (~13%), Highest Bioavailability, stimulates collagen. It is a functional therapeutic agent, not just a mineral source.
What is the elemental calcium content?
It is approximately 13%. While this seems lower than Calcium Carbonate (40%), the absorption rate is nearly 95% (vs 30% for Carbonate), so the effective dose reaching the bones is significantly higher.
Is it suitable for kidney stone patients?
Studies suggest that Calcium L-Threonate is excreted mainly via urine but does not significantly increase oxalate precipitation, making it safer than traditional calcium salts for those prone to stones (though medical advice is always recommended).
References
1.Wang, Y., et al. (2011). Calcium L-threonate prevents bone loss and increases bone strength in ovariectomized rats. Biological Trace Element Research.
2.Zhang, H., et al. (2008). Effects of calcium L-threonate on the expression of collagen I and III in cartilage of osteoarthritic rats. Orthopedic Journal.
3.He, X., et al. (2016). Bioavailability of calcium L-threonate in healthy volunteers. European Journal of Nutrition.
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