Forskolin
Forskolin Extract Manufacturer | Natural Fat Burner (CAS: 66575-29-9) Headline: Forskolin (Coleus Forskohlii Extract) | The Metabolic Activator (CAS: 66575-29-9) Sub-info: Assay 10% - 98% (HPLC) | Extracted from Coleus forskohlii Root | Natural Weight Management Agent. USP: • Direct cAMP Activator: Uniquely activates the enzyme Adenylate Cyclase, boosting intracellular cyclic AMP (cAMP) levels to accelerate fat metabolism. • Lean Body Mass: Clinically shown to promote fat loss while preserving lean muscle mass, unlike harsh stimulants. • Versatile Grades: Available in standardized 10%/20% powder for supplements and high-purity 95%/98% for R&D/Pharma applications.
Introduction
Forskolin (CAS: 66575-29-9) is a labdane diterpene extracted from the roots of the Indian plant Coleus forskohlii (Lamiaceae family). It has been used in Ayurvedic medicine for centuries but is now globally recognized for its unique biological mechanism.
Unlike caffeine or ephedrine which work via adrenal receptors, Forskolin works directly at the cellular level by activating Adenylate Cyclase. This raises cAMP (cyclic Adenosine Monophosphate) levels, a "second messenger" that triggers a cascade of beneficial effects: from breaking down stored fat (lipolysis) to relaxing smooth muscles (vasodilation) and lowering intraocular pressure. We offer a full range of specifications to meet diverse formulation needs.
Category：
Keywords：
forskolin
coleus
Functions
1.Weight Management (Lipolysis)
Elevated cAMP levels stimulate Sensitive Lipase (HSL), the enzyme responsible for breaking down triglycerides stored in fat cells into free fatty acids to be used as energy. This promotes significant fat loss without affecting muscle tissue.
2.Cardiovascular Health
Forskolin relaxes the smooth muscles of blood vessel walls (vasodilation), which can help maintain healthy blood pressure levels. It also exerts a positive inotropic effect, improving the heart's pumping efficiency.
3.Glaucoma Support (Eye Health)
Research indicates that Forskolin can lower Intraocular Pressure (IOP) by reducing the inflow of aqueous fluid into the eye, making it a key ingredient in specialized vision care formulations.
Applications
1.Dietary Supplements (Weight Loss)
• Specs: 10% or 20% Forskolin Powder.
• Claim: "Metabolism Booster," "Belly Fat Burner."
• Format: Capsules, Fat Burner Stacks (often paired with Garcinia Cambogia or Green Tea Extract).
2.Sports Nutrition
• Specs: 20% - 40% Forskolin.
• Benefit: Increases free testosterone levels naturally and supports energy production (ATP) via cAMP pathways, ideal for cutting phases.
3.Pharmaceuticals & Research
• Specs: 95% - 99% Pure Forskolin.
• Usage: As a reference standard or API for glaucoma eye drops and cardiovascular drugs.
Flow Chart
Root Extraction & Chromatography
1.Raw Material: Dried Coleus forskohlii roots (Sourced from India/China GAP bases).
2.Extraction: Solvent extraction (Ethanol) to obtain crude oleoresin.
3.Filtration: Removing plant fibers and insolubles.
4.Concentration: Vacuum evaporation.
5.Purification:
• For 10-20%: Standardization with carrier (Maltodextrin).
• For 95-98%: Repeated Column Chromatography and Crystallization.
6.Drying: Spray Drying or Vacuum Drying.
7.Milling: Pulverizing to 80 Mesh.
8.QC Testing: HPLC Assay, Heavy Metals, Solvent Residue.
9.Packing: 25kg Drums (Food Grade) / 1kg Tins (Pharma Grade).
Quality Standard of Lactoferrin
Product: Coleus Forskohlii Extract 20% (Forskolin)
| Item | Specification | Result |
| Appearance | Yellow to brown fine powder | Conforms |
| Odor | Characteristic herbal odor | Conforms |
| Forskolin Content (HPLC) | ≥ 20.0% | 20.8% |
| Loss on Drying | ≤ 5.0% | 3.2% |
| Ash | ≤ 5.0% | 2.1% |
| Heavy Metals (Pb) | ≤ 10 ppm | Conforms |
| Arsenic (As) | ≤ 2.0 ppm | Conforms |
| Cadmium (Cd) | ≤ 1.0 ppm | Conforms |
| Solvent Residue | ≤ 5000 ppm (Ethanol) | < 50 ppm |
| Total Plate Count | < 1000 cfu/g | < 100 cfu/g |
Method of Analysis of Lactoferrin
HPLC (High-Performance Liquid Chromatography)
• Standard: We use an external standard method (Sigma Reference Standard) to quantify Forskolin.
• Why: Many cheaper products use UV testing which falsely elevates the "content" by including other diterpenes. Only HPLC can distinguish true Forskolin from other Coleus components.
Reference Chromatogram of Lactoferrin Reference Substance
The HPLC chromatogram shows a distinct peak for Forskolin at a retention time of approximately 12-14 minutes (depending on column/method). High-purity grades (98%) will show a single dominant peak with >98% area normalization.
Stability and Safety
Stability Studies
• Hygroscopicity: The extract powder is moderately hygroscopic.
• Storage: Keep in tightly sealed containers.
• Shelf Life: 24 months when stored cool and dry. High temperatures (>40°C) may cause the powder to cake but rarely degrades the active Forskolin content significantly.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance (at supplement concentrations).
• Side Effects: High doses may cause minor gastrointestinal upset or low blood pressure (hypotension).
• Handling: Wear dust mask.
• Storage: Store away from moisture.
Customer Comments
Quality Director, US Supplement Brand
2026.03.18
★★★★☆
Production Manager, Contract Manufacturer (Poland)
2026.03.18
★★★★☆
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FAQ
What is the correct dosage for Forskolin?
Clinical studies typically use 250mg of a 10% extract (providing 25mg pure Forskolin) taken twice daily. For a 20% extract, the dosage would be ~125mg twice daily.
Is "Fuskelin" the same as Forskolin?
Yes. "Fuskelin" (and similar spellings like Colforsin) is a common transliteration or synonym for Forskolin. The chemical structure (CAS 66575-29-9) is identical.
Can it be used in coffee or tea?
Yes, Forskolin powder is heat stable enough for hot beverages, but it has a distinct herbal/bitter taste. It is best suited for capsules or flavored functional drink mixes.
References
1.Godard, M. P., et al. (2005). Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obesity Research.
2.Loftus, H. L., et al. (2015). Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects. Nutrients.
3.Seamon, K. B., & Daly, J. W. (1981). Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. PNAS.
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