Magnesium L-threonate
Magnesium L-Threonate Manufacturer | The Only Magnesium for Brain Health (CAS: 778571-57-6) Headline: Magnesium L-Threonate Powder | The "Brain Magnesium" that Crosses the BBB (CAS: 778571-57-6) Sub-info: Assay ≥ 98.0% | Elemental Mg ~7.2% - 8.3% | Neuroplasticity Support | USP Grade. USP: • Blood-Brain Barrier (BBB) Penetration: The only form of magnesium clinically proven to significantly increase magnesium levels in the cerebrospinal fluid and brain tissue. • Cognitive Restoration: Enhances synaptic density and plasticity, effectively reversing "brain aging" and improving short-term memory (based on Cell published research). • Superior Bioavailability: Highly soluble and gentle on the stomach, avoiding the laxative effects common with other magnesium salts.
Introduction
Magnesium L-Threonate (MgT, CAS: 778571-57-6) is a unique magnesium salt of L-Threonic acid (a Vitamin C metabolite). It was developed by scientists at MIT specifically to solve the problem of magnesium deficiency in the brain.
While standard magnesium supplements (like Citrate or Oxide) are poorly absorbed by the nervous system, Magnesium L-Threonate utilizes specific transport channels to bypass the Blood-Brain Barrier. We manufacture high-purity 98% Magnesium L-Threonate Powder, offering a cutting-edge ingredient for Nootropics, Sleep Aids, and Anti-Aging Formulas.
Category：
Keywords：
magnesium
l-threonate
Functions
1.Reversing Brain Aging (Memory & Learning)
By elevating brain magnesium levels, MgT facilitates the activation of NMDA receptors, which are crucial for learning and memory. It increases the density of synapses (synaptogenesis) in the hippocampus, helping to restore cognitive function in aging adults to levels seen in youth.
2.Sleep Quality & Anxiety Relief
It regulates the HPA axis (hypothalamic-pituitary-adrenal) and modulates GABA receptors. Users report deeper sleep, reduced sleep latency, and a calmer mind without the drowsiness associated with melatonin.
3.Neuroprotection
MgT helps prevent the loss of synapses associated with neurodegenerative conditions. It supports overall neuronal health and structural integrity (neuroplasticity).
Applications
1.Nootropic Capsules
• Usage: 2000mg per day (providing ~144mg elemental Mg).
• Target: Professionals seeking focus, Seniors fighting cognitive decline ("Senior Moments").
• Claim: "Clinically shown to improve memory speed."
2.Sleep & Mood Support
• Formulation: Combined with L-Theanine or GABA.
• Benefit: A non-sedative relaxant that targets the root cause of nervous tension (mineral deficiency in the brain).
3.Functional Beverages
• Solubility: Excellent water solubility and neutral taste make it superior to Magnesium Glycinate (which can taste metallic/soapy) for drink mixes.
Flow Chart
Chelation & Crystallization
1.Raw Material: L-Threonic Acid (derived from Vitamin C fermentation) + Magnesium Hydroxide/Carbonate.
2.Chelation Reaction: Controlled reaction in aqueous solution to form the Magnesium L-Threonate complex.
3.Filtration: Removing insoluble impurities.
4.Concentration: Vacuum evaporation.
5.Crystallization: Ethanol precipitation or cooling crystallization to obtain high purity.
6.Centrifugation: Separating the crystals.
7.Drying: Spray Drying or Vacuum Drying.
8.Milling: Pulverizing to 80 Mesh.
9.QC Testing: Magnesium Content (ICP/Titration) & Identification.
10.Packing: 25kg Fiber Drums.
Quality Standard of Lactoferrin
Product: Magnesium L-Threonate 98% (Food/Pharma Grade)
| Item | Specification | Result |
| Appearance | White to off-white powder | Conforms |
| Odor | Odorless | Conforms |
| Assay (on dry basis) | ≥ 98.0% | 99.2% |
| Magnesium Content | 7.2% ~ 8.3% | 7.5% |
| Loss on Drying | ≤ 3.0% | 1.2% |
| pH (1% Solution) | 6.0 ~ 8.0 | 7.1 |
| Heavy Metals (Pb) | ≤ 10 ppm | Conforms |
| Arsenic (As) | ≤ 2.0 ppm | Conforms |
| Solubility | Soluble in water | Conforms |
| Microbiology | Total Plate Count < 1000 cfu/g | < 100 cfu/g |
Method of Analysis of Lactoferrin
Complexometric Titration & ICP-MS
• Magnesium Content: We use standard EDTA titration or ICP-MS to verify the elemental magnesium level falls strictly within the 7.2% - 8.3% range.
• Threonate Identity: Confirmed via HPLC or IR Spectroscopy to ensure it is the authentic chelate, not a dry blend of magnesium and threonic acid.
Reference Chromatogram of Lactoferrin Reference Substance
The Infrared (IR) Absorption Spectrum matches the standard reference. The characteristic peaks of the carboxylate group of L-threonic acid coordinated with the magnesium ion are clearly visible, confirming the chelated structure.
Stability and Safety
1.Stability Studies
• Shelf Life: 24 months.
• Condition: Stable in dry powder form. Aqueous solutions should be consumed relatively quickly or preserved.
• Hygroscopicity: Moderately hygroscopic. Keep containers tightly closed.
2.Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance.
• Safety: Safe (GRAS). Unlike Magnesium Citrate, it has a very low risk of causing diarrhea because it is absorbed so efficiently before reaching the colon.
• Storage: Store in a cool, dry place.
Customer Comments
Product Manager, Nootropic Brand (USA)
2026.03.16
★★★★☆
Operations Lead, Contract Manufacturer (UK)
2026.03.16
★★★★☆
Our Certificates
CERTIFICATE
CERTIFICATE
FDA
ISO
HALAL
HACCP
Our Clients
Exhibitions
• SupplySide West (Las Vegas)
• Vitafoods Europe (Geneva)
• Natural Products Expo West (Anaheim)
CAC 24th
FIC 2023
FIC 2022
CPHI 2025
CPHI 2024
CPHI 2023
CPHI & PMEC China 2025
CAC Shanghai
CPHI & PMEC 2024
CPHI & PMEC China Shanghai
FIC Shanghai
FIC2024
CPHI Korea
SupplySideWEST Las Vegas
SupplySideWEST 2023
Vitafoods Europe Switzerland
Wagri Guangzhou
In-Cosmetics Global
SupplySide West (Las Vegas)
SupplySide West (Las Vegas)
Vitafoods Europe (Geneva)
CPhI Worldwide
FAQ
Why is the elemental magnesium content so low (7-8%)?
The L-Threonate molecule is large. Although the percentage of Mg is lower than Magnesium Oxide (60%), the absorption and bioavailability to the brain are exponentially higher. You don't need a high dose of Mg; you need the right carrier to get it into the brain.
What is the recommended dosage?
Standard clinical dosage is 2,000 mg of Magnesium L-Threonate powder per day. This provides approximately 144 mg of elemental magnesium.
Can it be mixed with other magnesiums?
Yes. Some brands mix it with Magnesium Glycinate to boost total body magnesium while using Threonate specifically for the brain benefits.
References
1.Slutsky, I., et al. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron. (The landmark MIT study).
2.Liu, G., et al. (2016). Efficacy and safety of MMFS-01, a synapse density enhancer, for treating cognitive impairment in older adults: a randomized, double-blind, placebo-controlled trial. Journal of Alzheimer's Disease.
3.Wang, J., et al. (2013). Magnesium L-threonate prevents and restores memory deficits associated with neuropathic pain by inhibition of TNF-α. Pain Physician.
Related Products
Our Global Presence：Pioneer Biotech | Pioneer Bio Inc. | Kono Chem | Kono Chem (RU)
P&K INTERNATIONAL PTE. LTD.