Andrographolide
Andrographolide Manufacturer | Natural Anti-Inflammatory & Antiviral Headline: Premium Andrographolide Manufacturer | High Purity Plant Extract (CAS: 5508-58-7) Sub-headline: 98% HPLC Purity | Andrographis Paniculata Origin | Potent Immune Support Agent Unique Selling Proposition (USP): • Standardized Potency: Strict HPLC analysis ensuring >98% Andrographolide content, differentiating from low-quality crude extracts. • Broad Spectrum Efficacy: Clinically recognized for its upper respiratory tract support and anti-inflammatory properties. • Solvent-Free Processing: Extracted using eco-friendly Ethanol/Water methods to minimize residue limits.
Introduction
Andrographolide (CAS: 5508-58-7) is the primary bioactive diterpenoid lactone isolated from the leaves of Andrographis paniculata, widely known as the "King of Bitters" in Ayurveda and Traditional Chinese Medicine (TCM).
It appears as a white crystalline powder with an intensely bitter taste. Modern pharmacology has validated its powerful anti-inflammatory, antiviral, and hepatoprotective activities. It is a key ingredient in formulations for cold/flu relief, joint health, and liver support supplements.
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Functions
1.Upper Respiratory Health (Antiviral)
• Mechanism: Inhibits viral replication and modulates immune response.
• Action: Significantly reduces the severity and duration of common cold and flu symptoms (sore throat, fever). Often used as a natural alternative to NSAIDs.
2.Anti-Inflammatory (Joint Health)
• Mechanism: Inhibits NF-kB signaling pathway and reduces pro-inflammatory cytokines (TNF-α, IL-6).
• Action: Provides relief in rheumatoid arthritis and general inflammatory conditions by targeting the root cause of inflammation.
3.Hepatoprotection (Liver Support)
• Mechanism: Increases antioxidant enzyme activity (SOD, Catalase) in liver cells.
• Action: Protects the liver against toxin-induced damage (e.g., alcohol, CCl4), comparable to Silymarin.
Applications
1.Immunity Supplements
• Application: Capsules and tablets for Cold & Flu season.
• Why it works: Its fast-acting immune-modulating properties make it a staple in "Immune Defense" blends, often paired with Vitamin C and Zinc.
2.Joint Support Formulas
• Application: Anti-arthritic supplements.
• Why it works: Reduces swelling and pain in joints, offering a plant-based option for long-term management of autoimmune conditions.
3.Functional Foods (Bitters)
• Application: Digestive bitters and tonics.
• Why it works: The extreme bitterness stimulates digestive juices and liver function (Note: requires taste masking or small dosages).
Flow Chart
1.Harvesting: Selection of mature Andrographis paniculata leaves (highest lactone content).
2.Extraction: Ethanol reflux extraction to isolate diterpenoids.
3.Filtration: Removal of chlorophyll and plant waxes.
4.Concentration: Vacuum evaporation of solvent.
5.Crystallization: Selective crystallization to separate Andrographolide from other diterpenes (like neoandrographolide).
6.Recrystallization: Purification to achieve 98% assay.
7.Drying: Vacuum drying.
8.Milling & Sieving: 80 mesh powder.
9.Packaging: 25kg Drum with double polyethylene liners.
Quality Standard of Lactoferrin
Product: Andrographolide 98% Source: Andrographis paniculata Leaf
| Item | Specification | Result |
| Appearance | White to off-white crystalline powder | Conforms |
| Assay (HPLC) | ≥ 98.0% | 98.4% |
| Melting Point | 229°C - 232°C | 230.5°C |
| Loss on Drying | ≤ 2.0% | 0.8% |
| Ash | ≤ 0.5% | 0.1% |
| Heavy Metals (Pb) | ≤ 10 ppm | < 3 ppm |
| Arsenic (As) | ≤ 2 ppm | < 0.5 ppm |
| Solvent Residue | Meets USP/EP limits | Conforms |
Method of Analysis of Lactoferrin
Test Method: HPLC (High-Performance Liquid Chromatography)
• Column: C18 (ODS).
• Mobile Phase: Methanol : Water (typically 60:40).
• Wavelength: UV detection at 224 nm or 254 nm.
• Validation: Must separate Andrographolide from related diterpenoids like 14-deoxy-11,12-didehydroandrographolide.
Reference Chromatogram of Lactoferrin Reference Substance
(Description) A sharp, major peak at the retention time of the Andrographolide standard. Minor peaks (<2%) may represent trace amounts of neoandrographolide or dehydroandrographolide, which are natural co-occurring compounds.
Stability and Safety
Stability Studies
• Light Sensitivity: Sensitive to light.
• Stability: Stable in solid state but can degrade in solution at high pH.
• Shelf Life: 24 Months when stored in closed containers away from light and moisture.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous natural extract.
• Handling: Bitter taste can linger; avoid inhalation.
• Storage: Store in a cool, dry place. Protect from light.
Customer Comments
Product Manager, Natural Pharma (Sweden)
2026.03.04
★★★★☆
Sourcing Lead, HerbTech (USA)
2026.03.04
★★★★☆
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FAQ
Is this the same as Andrographis Extract 10%?
No. This is the purified single molecule (98%), whereas the 10% extract is a crude mixture containing other plant compounds. The 98% grade is used when a specific, high-potency dosage of the active ingredient is required.
How bitter is it?
Extremely bitter. It is named "King of Bitters" for a reason. For oral liquids, taste-masking technology is essential. For capsules/tablets, film coating is recommended to prevent aftertaste.
What is the recommended dosage?
Clinical studies for colds often use 60mg to 200mg of Andrographolide per day, divided into doses.
References
1.Caceres, D.D., et al. (2006). "Use of Andrographis paniculata for the relief of symptoms of the common cold." Phytomedicine.
2.Burgos, R.A., et al. (2009). "Andrographolide inhibits IFN-gamma and IL-2 cytokine production..." Journal of Pharmacology and Experimental Therapeutics.
3.Chao, W.W., et al. (2010). "Bioactive compounds from Andrographis paniculata (Burm. f.) Nees." Chinese Medicine.
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