Chondroitin sulfate
Alpha-Bisabolol Manufacturer | Natural Soothing Agent (CAS: 515-69-5) Source: Candeia Tree / Matricaria chamomilla | Purity: $\ge$ 95% / 85% (GC) | Certifications: ISO9001, COSMOS Approved, Halal USP: Natural Anti-Irritant | High Purity (-)-$\alpha$-Bisabolol | Ready Stock in Local Warehouse
Introduction
Alpha-Bisabolol (CAS: 515-69-5; Chemical Formula: C${15}$H${26}$O) is a natural monocyclic sesquiterpene alcohol. While originally found in German Chamomile (Matricaria chamomilla), it is primarily extracted industrially from the wood of the Candeia tree (Eremanthus erythropappus) to ensure high purity and sustainability.
Renowned for its subtle floral scent and potent biological activities, Bisabolol is a staple ingredient in the cosmetic industry. It acts as a bio-enhancer, improving the skin penetration of other active ingredients, while providing immediate soothing relief to sensitive or damaged skin.
Category：
Keywords：
alpha-bisabolol
bisabolol
matricaria
Functions
1.Anti-Inflammatory & Soothing
Bisabolol inhibits the release of pro-inflammatory cytokines (IL-6, TNF-$\alpha$) and reduces leukotriene synthesis. This makes it highly effective in calming skin redness (erythema), reducing stinging sensations, and soothing razor burn or sun-damaged skin.
2.Wound Healing & Tissue Regeneration
It accelerates the healing process by stimulating tissue regeneration. Its bacteriostatic and fungistatic properties also protect wounds from secondary infection, making it ideal for post-procedure care products.
3.Penetration Enhancer
Due to its lipophilic nature and interaction with stratum corneum lipids, Bisabolol increases the skin permeability of other active ingredients (such as antioxidants and vitamins), boosting the overall efficacy of cosmetic formulations.
Applications
Cosmetics:
• Sensitive Skin Care: Essential in baby products, after-shave balms, and creams for atopic dermatitis.
• Sun Care: Added to sunscreens and after-sun lotions to mitigate UV-induced inflammation.
• Oral Care: Used in toothpaste and mouthwash for its antibacterial effect against oral pathogens and gum soothing properties.
Pharmaceuticals: Used in topical ointments for wound healing and as an adjuvant in transdermal drug delivery systems.
Flow Chart
Our production ensures the isolation of the bioactive alpha-isomer:
1.Raw Material: Sustainable Candeia wood logs or Chamomile flowers.
2.Steam Distillation: Extraction of the essential oil containing Bisabolol.
3.Fractional Distillation: Purification to separate Alpha-Bisabolol from other terpenes.
4.Refinement: Further processing to achieve high purity ($\ge$ 95%).
5.Filtration: Removing particulates.
6.QC Testing: GC analysis to confirm isomer ratio and purity.
7.Packaging: Nitrogen-purged aluminum bottles to prevent oxidation.
Quality Standard of Lactoferrin
Product: (-)-Alpha-Bisabolol (Natural)
CAS No.: 515-69-5
| Item | Specification | Result |
| Appearance | Colorless to pale yellow viscous liquid | Conforms |
| Assay (GC) | $\ge$ 95.0% (Natural) / 85% (Synthetic) | 96.4% |
| Refractive Index (20°C) | 1.493 – 1.497 | 1.495 |
| Specific Gravity (20°C) | 0.924 – 0.932 | 0.928 |
| Optical Rotation | -55° to -58° (Natural isomer) | -56.5° |
| Solubility | Soluble in ethanol, oils; Insoluble in water | Conforms |
| Heavy Metals (Pb) | $\le$ 10 ppm | < 5 ppm |
| Arsenic (As) | $\le$ 2 ppm | < 1 ppm |
| Microbiology | Total Plate Count < 100 CFU/g | Conforms |
Method of Analysis of Lactoferrin
• Gas Chromatography (GC): The standard method for quantifying Bisabolol content and verifying the absence of synthetic impurities (if claiming Natural).
• Optical Rotation: Critical for distinguishing Natural (-)-Alpha-Bisabolol (highly active) from Synthetic racemic mixtures (lower activity).
Reference Chromatogram of Lactoferrin Reference Substance
The GC chromatogram displays a major peak for $\alpha$-Bisabolol (>95%). No significant peaks for Farnesol or other allergens are detected, ensuring the product is safe for hypoallergenic formulations.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Conditions: Stable in neutral to slightly acidic formulations.
• Data: Samples stored in closed containers at 25°C showed <1% degradation over 12 months. Bisabolol is compatible with most cosmetic ingredients but should be added during the cool-down phase (<50°C) to prevent volatilization.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous.
• Skin Compatibility: Excellent. Non-irritating and non-sensitizing.
• Storage: Store in a cool, dry place. Keep container tightly closed. Protect from light.
Customer Comments
Product Developer, Baby Care Brand, Germany
2026.03.03
★★★★☆
R&D Manager, Skincare Co., USA
2026.03.03
★★★★☆
Our Certificates
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Meet Manager Gao Beilei and our team at:
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FAQ
What is the difference between Natural and Synthetic Bisabolol?
Natural Bisabolol consists almost entirely of the active (-)-$\alpha$-isomer, which has strong anti-inflammatory properties. Synthetic Bisabolol is a racemic mixture containing only about 50% of the active isomer, requiring double the dosage to achieve the same effect. We supply both, but recommend Natural for premium efficacy.
Is Farnesol present in your product?
Our high-purity distillation process ensures Farnesol (a potential allergen) is removed or kept to trace levels (<0.1%), making it safe for leave-on products on sensitive skin.
What is the recommended usage rate?
Typical usage levels range from 0.1% to 1.0%. For sensitive skin products, 0.2% - 0.5% is common. It is oil-soluble and should be added to the oil phase or solubilized.
References
1.Kamatou, G.P., et al. (2010). "Review of the biological activities and synthesis of bisabolol." Journal of the American Oil Chemists' Society.
2.Maurya, A.K., et al. (2014). "$\alpha$-(-)-bisabolol reduces pro-inflammatory cytokine production..." Current Pharmaceutical Biotechnology.
3.Guy, R.H., et al. (1993). "Bisabolol as a skin penetration enhancer." International Journal of Pharmaceutics.
4.Cavalieri, E., et al. (2011). "$\alpha$-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells." Biochemical and Biophysical Research Communications.
5.Andersen, F.A. (1999). "Final report on the safety assessment of Bisabolol." International Journal of Toxicology.
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