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Aloin

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Introduction

P&K

Aloin (CAS: 1415-73-2), also known as Barbaloin, is the bitter, yellow-brown colored compound found in the exudate of at least 68 Aloe species, most notably Aloe barbadensis Miller (Curacao Aloe) and Aloe ferox (Cape Aloe). Chemically, it is a C-glycoside derivative of anthraquinone.

As a specialized manufacturer, we utilize advanced Macroporous Resin Separation Technology to isolate high-purity Aloin A+B (ranging from 18% to 95%). Unlike crude aloe extracts, our refined Aloin offers precise dosage control for Pharmaceutical (Laxative) and Cosmetic (Skin Brightening) applications, ensuring consistent efficacy without the variability of raw plant material.

Category：

Cosmetics

Keywords：

manufacturer

separation

pharmaceutical

Functions

Aloin is a dual-function bioactive agent with distinct pharmaceutical and cosmetic mechanisms.

1.Stimulant Laxative (MOA - Pharma):

Upon oral ingestion, Aloin is hydrolyzed by colonic bacteria into the active metabolite Aloe-emodin-9-anthrone. This metabolite stimulates peristalsis of the colon and increases water content in the intestinal lumen by inhibiting Na+/K+ ATPase channels, providing effective relief for constipation.

2.Tyrosinase Inhibition (MOA - Cosmetic):

Studies indicate that Aloin inhibits tyrosinase activity (the enzyme responsible for melanin production) competitively. This makes it a potent natural Skin Whitening Agent, effectively reducing hyperpigmentation and UV-induced darkening.

3.Anti-Inflammatory & Antimicrobial:

It inhibits the cyclooxygenase (COX-2) pathway, reducing skin inflammation and redness. It also exhibits broad-spectrum antibacterial activity against Staphylococcus aureus and E. coli, aiding in acne treatment.

Applications

Pharmaceuticals & Supplements:

• Active Pharmaceutical Ingredient (API) in stimulant laxative tablets, capsules, and herbal detox teas.

Cosmetics & Personal Care:

• Whitening Serums: For its depigmenting properties.

• Acne Treatments: Utilizing its anti-inflammatory and antibacterial effects.

• After-Sun Repair: Soothes UV-damaged skin.

Agrochemicals:

• Used as a natural biopesticide due to its bitter taste and antifeedant properties against certain crop pests.

Flow Chart

Quality Standard of Lactoferrin

Spec: Aloin 20% / 40% / 90% (HPLC)

Item	Specification	Result	Method
Maker Compounds	Aloin(A+B)≥95.00%	95.24%	HPLC
Appearance	Fine Powder	Conforms	Visual
Color	Light Yellow	Conforms	Visual
Odor	Characteristic	Conforms	Organoleptic
Taste	Characteristic	Conforms	Organoleptic
Physical Characteristics
Particle Size	NLT100%Through 80	Conforms	CP2015
Loss on Drying	≤4.0%	2.22%	GB5009.3
Ash content	≤2.0%	1.06%	GB5009.4
Heavy metals
Pb	≤1.5ppm	Conforms	GB5009.12
Arsenic	≤1.0ppm	Conforms	GB5009.11
Hg	≤0.3ppm	Conforms	GB5009.17
Cd	≤0.3ppm	Conforms	GB5009.15
Microbiological Tests
Total Plate Count	≤1000cfu/g	Conforms	GB 4789.2
Total Yeast & Mold	≤50cfu/g	Conforms	GB 4789.15
Coliforms group	Negative	Negative	GB 4789.3
Salmonella	Negative	Negative	GB 4789.4
Staphylococcus	Negative	Negative	GB 4789.10
Packing	25kg/drum. Packing in paper drum and two plastic-bags inside
storage	Store in a well-closed place with constant low temperature and no direct sun light.

Method of Analysis of Lactoferrin

1. Instruments

High performance liquid chromatograph, P3100 high pressure constant flow pump, UV3100 UV detector.

2. Reagents

Methanol is chromatographically pure and water is ultrapure water.

3. Chromatographic conditions

• Chromatographic column: C18 column (5um) 4.6×250nm

• Mobile phase: methanol-1% glacial acetic acid (60:40)

• Column temperature: room temperature

• Flow rate: 1.0ml/min

• Detection wavelength: 293nm.

4 The preparation of the reference solution

Precisely weigh 10.0 mg of the reference substance aloe verain, dissolve it in methanol, and dilute to 100 ml as the reference substance solution.

5. Preparation of sample solution

Precisely weigh an appropriate amount of the sample, dissolve it in methanol, and dilute to 100ml as the sample solution.

Reference Chromatogram of Lactoferrin Reference Substance

Stability and Safety

Stability Studies

• Shelf Life: 24 months.

• Light Sensitivity: Aloin is highly sensitive to light and oxidizes to Aloe-emodin (which is darker) upon exposure.

• pH Stability: Most stable in acidic to neutral pH (3.0 - 6.0). Rapidly degrades in alkaline solutions.

• Storage: Must be stored in light-resistant containers (double PE bags inside fiber drums) in a cool, dry place.

Safety & Handling (MSDS Summary)

• Classification: Irritant (Xi).

• Handling: Avoid inhalation of dust. Bitter taste may persist if airborne dust is ingested. Wear mask and gloves.

• Dosage Warning: As a laxative, strict adherence to recommended dosage is required to prevent abdominal cramping.

long-term stability testing of Aloin

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MSDS of Aloin

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Customer Comments

Purchasing Manager, US Herbal Supplement Co.

2026.03.02

★★★★☆

"Your Aloin 40% powder has excellent solubility for our detox tea blend. The bitterness is consistent, which is crucial for our flavor profile."

R&D Director, Korean Cosmetic Brand

2026.03.02

★★★★☆

"We use the 90% grade for a high-end whitening ampoule. The color is much lighter than other sources, which makes formulation easier."

Our Certificates

CERTIFICATE

FDA

ISO

HALAL

HACCP

Our Clients

Exhibitions

• SupplySide West (Las Vegas)

• CPhI Worldwide

• In-Cosmetics Global

CPHI 2025

CPHI 2024

CPHI 2023

CPHI & PMEC China 2025

CAC 24th

CAC Shanghai

CPHI & PMEC 2024

CPHI & PMEC China Shanghai

FIC2024

FIC 2023

FIC 2022

FIC Shanghai

CPHI Korea

SupplySideWEST Las Vegas

SupplySideWEST 2023

Vitafoods Europe Switzerland

Wagri Guangzhou

In-Cosmetics Global

SupplySide West (Las Vegas)

Vitafoods Europe (Geneva)

CPhI Worldwide

FAQ

What is the difference between Aloin A and Aloin B?

They are diastereomers. Naturally, Aloin exists as a mixture. Over time or during processing, they can interconvert. Our specification measures the sum of both (A+B) to ensure total potency.

Is this product suitable for "Aloe Vera Gel" drinks?

No. Aloin is the laxative component found in the leaf latex (yellow sap). "Aloe Vera Gel" drinks typically require the removal of Aloin (<10ppm) to avoid the laxative effect. This product is for specific laxative or cosmetic applications, not general beverage consumption.

How do you control the bitter taste?

Aloin is naturally intensely bitter (used as a bitterness standard). For oral supplements, we recommend encapsulation to mask the taste.

References

1.Gjerstad, G. (1971). "Chemical studies of Aloe vera juice. I. Amino acid analysis." Advances in Frontiers of Plant Sciences.

2.Ishii, Y., et al. (1990). "Studies of aloe. III. Mechanism of cathartic effect." Chemical and Pharmaceutical Bulletin.

3.Choi, S., et al. (2002). "Aloin inhibits melanogenesis in B16 melanoma cells via the downregulation of tyrosinase activity."

4.Cosmetic Ingredient Review (CIR). "Safety Assessment of Aloe barbadensis-derived ingredients."

5.European Medicines Agency (EMA). "Community herbal monograph on Aloe barbadensis."

Aloin

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