Glucuronolactone
Glucuronolactone Manufacturer | Energy & Detox Ingredient (CAS: 32449-92-6) Headline: Glucuronolactone Powder Manufacturer | The Fuel for Energy Drinks (CAS: 32449-92-6) Sub-info: Assay ≥ 99.0% | USP/JP/EP Grade | White Crystalline Powder | Instant Solubility. USP: • Energy Booster: A key synergistic ingredient in energy formulations, working alongside Caffeine and Taurine. • Liver Support: Naturally metabolized into Glucaric Acid to aid in the detoxification of pollutants and drugs. • Global Standard: Fully compliant with major international pharmacopoeias for functional food and pharma use.
Introduction
Glucuronolactone (D-Glucurono-3,6-lactone, CAS: 32449-92-6) is a naturally occurring metabolite formed from glucose in the liver. It is a structural component of nearly all connective tissues.
Best known as a staple ingredient in leading Energy Drinks (like Red Bull and Monster), Glucuronolactone is scientifically valued for its ability to reduce mental fatigue and improve physical performance. Beyond energy, it plays a critical medical role as a precursor to glucuronic acid, facilitating Glucuronidation—the body’s primary Phase II detoxification pathway for eliminating toxins and carcinogens. We offer a high-purity, white crystalline powder suitable for beverages, supplements, and hepatoprotective drugs.
Category：
Keywords：
energy
glucuronolactone
ingredient
Functions
1.Ergogenic & Anti-Fatigue Effect
Glucuronolactone improves glycogen synthesis and storage in the liver. By ensuring a steady supply of glycogen fuel, it helps delay the onset of physical exhaustion and enhances mental alertness during periods of stress or intense exercise.
2.Liver Detoxification (Glucuronidation)
In the body, it hydrolyzes into Glucuronic Acid, which binds to toxins (alcohol, pollutants, drugs) to form water-soluble conjugates that are easily excreted in urine. This "scavenging" effect protects the liver and kidneys from toxicity.
3.Joint & Tissue Health
As a precursor to Chondroitin Sulfate and Hyaluronic Acid, it supports the maintenance of healthy collagen and connective tissues, contributing to joint flexibility and skin integrity.
Applications
1.Functional Beverages (Energy Drinks)
• Role: Core active ingredient alongside Taurine, Caffeine, and B-Vitamins.
• Benefit: Reduces the "crash" associated with caffeine alone; improves reaction time and concentration.
2.Dietary Supplements (Liver Health)
• Role: "Hangover Defense" or "Daily Detox" capsules.
• Benefit: Supports the liver's natural ability to process alcohol and metabolic waste.
3.Pharmaceuticals
• Role: API for hepatoprotective drugs (e.g., treatment of hepatitis or poisoning).
• Benefit: Clinically proven to support liver function recovery.
Flow Chart
Chemical Synthesis & Purification
1.Raw Material: Corn Starch (Glucose source) → Oxidized to Gluconic Acid.
2.Synthesis: Catalytic oxidation of Glucose/Starch to produce D-Glucuronic Acid.
3.Lactonization: Dehydration process under controlled acidic conditions to form the lactone ring (Glucuronolactone).
4.Crystallization: Cooling to form pure crystals.
5.Centrifugation: Separating crystals from the mother liquor.
6.Washing: Removing residual impurities.
7.Drying: Fluidized bed drying.
8.Sieving: Passing 40-80 Mesh.
9.QC Testing: HPLC Purity & Melting Point check.
10.Packing: 25kg Cartons/Drums.
Quality Standard of Lactoferrin
Product: D-Glucuronolactone (Food/Pharma Grade)
| Item | Specification | Result |
| Appearance | White crystalline powder | Conforms |
| Odor | Odorless | Conforms |
| Assay (Titration) | 99.0% ~ 102.0% | 99.8% |
| Melting Point | 170°C ~ 176°C | 174.5°C |
| Specific Rotation | +18.0° ~ +20.0° | +19.2° |
| Loss on Drying | ≤ 0.5% | 0.1% |
| Residue on Ignition | ≤ 0.1% | 0.04% |
| Heavy Metals (Pb) | ≤ 10 ppm | Conforms |
| Arsenic (As) | ≤ 1.0 ppm | Conforms |
| Sulfate (SO4) | ≤ 0.01% | Conforms |
| Solubility | Soluble in water (slowly hydrolyzes) | Conforms |
Method of Analysis of Lactoferrin
Titration & Melting Point
• Titration: The standard pharmacopoeial method (USP) involves titration with Sodium Hydroxide (NaOH) to determine purity.
• Specific Rotation: A polarimeter is used to confirm the correct optical isomer (D-form), ensuring biological activity.
Reference Chromatogram of Lactoferrin Reference Substance
The Infrared (IR) Absorption Spectrum matches the Reference Standard (USP RS), confirming the lactone structure. The HPLC purity check shows a single peak with no significant by-products from the oxidation process.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Conditions: Stable in dry powder form.
• Hydrolysis: In aqueous solution, it slowly equilibrates with Glucuronic Acid. This reaction is pH-dependent. Energy drink formulators should adjust pH to maintain stability.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance.
• Safety: GRAS (Generally Recognized as Safe) status.
• Handling: Standard industrial hygiene.
• Storage: Store in a cool, dry place. Keep container tightly closed to prevent moisture absorption.
Customer Comments
Purchasing Manager, Sports Nutrition Co. (USA)
2026.02.28
★★★★☆
Quality Director, Pharmaceutical Manufacturer (Japan)
2026.02.28
★★★★☆
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FAQ
What is the main benefit of adding Glucuronolactone to energy drinks?
It works synergistically with caffeine and taurine to improve mental performance and reaction time. It is also believed to help the body eliminate metabolic waste products generated during exercise (detox effect).
Is it natural or synthetic?
While Glucuronolactone occurs naturally in the body and in some plants/gums, the commercial scale product is synthesized from glucose/corn starch to ensure high purity and consistency required for food/pharma use.
What is the solubility?
It is freely soluble in water. However, upon dissolution, it slowly hydrolyzes to form an equilibrium with glucuronic acid. This is a normal chemical property and does not affect its safety or efficacy in beverages.
References
1.Tamura, S., et al. (1968). Metabolism of glucuronolactone. The Japanese Journal of Pharmacology.
2.Reid, D. S., et al. (2009). Energy drinks and the neurophysiological impact of caffeine, taurine and glucuronolactone. Nutritional Neuroscience.
3.EFSA Panel on Food Additives. (2009). The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks. The EFSA Journal.
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