Carboxymethyl chitosan
Carboxymethyl Chitosan Manufacturer | High-Purity Water-Soluble Chitosan Derivative (CAS: 83512-85-0) Headline: Premium Carboxymethyl Chitosan Manufacturer | ≥98% Purity Bioactive Material (CAS: 83512-85-0) Sub-info: Fully Water-Soluble | Superior Film-Forming & Anti-Aging Properties | Cosmetic & Pharmaceutical Grade USP: Ready Stock in US/EU | Excellent Biocompatibility & Non-Toxicity | Advanced Carboxymethylation Process
Introduction
Carboxymethyl Chitosan (CMC) (CAS: 83512-85-0) is a high-performance, water-soluble derivative of the natural polymer chitosan. Through the introduction of carboxymethyl groups into the chitosan molecular chain, its solubility is significantly enhanced across a broad pH range, overcoming the limitations of traditional chitosan which only dissolves in acidic media.
As a professional B2B manufacturer, we provide High-Purity Carboxymethyl Chitosan Powder (98%). This bioactive polymer combines the unique properties of chitin derivatives—such as antimicrobial activity and moisture retention—with superior ease of formulation, making it an essential ingredient for advanced cosmeceuticals and medical dressings.
Category：
Keywords：
chitosan
carboxymethyl
Functions
Carboxymethyl Chitosan is a multifunctional biopolymer with proven clinical and cosmetic benefits:
1.Advanced Moisture Retention (MOA):
The presence of both carboxyl (-COOH) and amino (-NH2) groups allows CMC to form a structured hydrated film on the skin surface. It mimics the skin's natural moisturizing factors (NMF), effectively locking in moisture and preventing transepidermal water loss (TEWL).
2.Antioxidant & Anti-Aging Efficacy:
CMC acts as a scavenger for reactive oxygen species (ROS). It inhibits lipid peroxidation and protects dermal fibroblasts from oxidative stress, thereby delaying the skin's aging process and reducing the appearance of fine lines.
3.Antimicrobial & Anti-Inflammatory:
Its cationic nature allows it to interact with microbial cell membranes, providing a natural preservative effect in formulations and soothing irritated skin.
4.Controlled Release & Delivery:
Due to its polymeric structure, CMC can encapsulate active ingredients (like vitamins or peptides), providing a sustained release mechanism that enhances the bioavailability of topically applied actives.
Applications
• Anti-Aging Serums & Creams: Primary active for moisture locking, skin firming, and wrinkle reduction.
• Facial Masks & Gels: Utilized for its superior film-forming ability and soothing effects on sensitive skin.
• Hair Care Products: Adds a protective, moisturizing layer to the hair shaft, improving shine and reducing static.
• Medical & Wound Care: Used in bioactive dressings to accelerate tissue regeneration and provide an antimicrobial barrier.
Flow Chart
Precision Manufacturing Process (Eco-friendly Solvent Method):
1.Chitosan Selection: High-grade chitosan from sustainable crustacean sources.
2.Alkalization: Treatment with sodium hydroxide at low temperatures to activate the hydroxyl groups.
3.Carboxymethylation: Reaction with chloroacetic acid under strictly controlled thermal conditions to ensure high degree of substitution.
4.Neutralization: Precise pH adjustment to ensure full water solubility.
5.Purification: Multi-stage dialysis or alcohol precipitation to remove residual salts and reagents.
6.Vacuum Drying: Low-temperature drying to prevent molecular chain degradation.
7.Sifting & Packing: 80-mesh powder sifting in a GMP-compliant cleanroom.
Quality Standard of Lactoferrin
Spec: Carboxymethyl Chitosan ≥98.0%
| Item | Specification | Result |
| Active Ingredient | Carboxymethyl Chitosan | ≥ 98.0% |
| Appearance | White to Off-white Fine Powder | Conforms |
| Solubility (1% in water) | Clear, Colorless to Pale Yellow Solution | Conforms |
| Degree of Substitution | ≥ 80% | 85.5% |
| pH (1.0% solution) | 6.5 – 8.5 | 7.2 |
| Loss on Drying | ≤ 10.0% | 6.5% |
| Heavy Metals | ≤ 10 ppm | < 5 ppm |
| Lead (Pb) | ≤ 1.0 ppm | 0.2 ppm |
| Arsenic (As) | ≤ 1.0 ppm | 0.1 ppm |
| Microbiology | Total Plate Count ≤ 1,000 cfu/g | Conforms |
Method of Analysis of Lactoferrin
• Analytical Method: Potentiometric Titration (for Degree of Substitution) and UV-Vis Spectrophotometry.
• Purity Check: We employ High-Performance Liquid Chromatography (HPLC) combined with Refractive Index (RI) detection to monitor molecular weight distribution and ensure the absence of unreacted monomeric impurities.
Reference Chromatogram of Lactoferrin Reference Substance
NMR
Stability and Safety
Stability Studies
• Shelf Life: 24-month (2-year) shelf life based on Long-term Stability data.
• Long-term Stability: Tests at 25°C ± 2°C / 60% ± 5% RH confirm that Appearance, Solubility, and pH remain within specification for 24 months.
• Accelerated Stability: 6-month data (40°C ± 2°C / 75% ± 5% RH) ensures the product maintains its chemical integrity during transport and varying storage conditions.
• Data Consistency: Tested parameters (Appearance, Purity, Substitution Degree) at 0, 6, 12, and 24 months remained within the limits defined in Module 6.
Safety & Handling (MSDS Summary)
• Classification: Classified as non-hazardous. CMC is a GRAS (Generally Recognized as Safe) material.
• Handling: Wear standard PPE (safety glasses and masks) to prevent dust inhalation during bulk processing.
• Storage: Store in a cool, dry place (<25°C); keep container tightly closed. Product is slightly hygroscopic.
Customer Comments
R&D Director, South Korean Skincare Group
2026.02.25
★★★★☆
Plant Manager, German Cosmeceutical Manufacturer
2026.02.25
★★★★☆
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FAQ
What is the main benefit of Carboxymethyl Chitosan over regular Chitosan?
The primary benefit is water solubility. CMC dissolves easily in water at neutral pH, whereas regular chitosan requires acidic conditions, making CMC much easier to use in standard cosmetic and pharmaceutical formulations.
How do you identify quality?
Quality is identified through the Degree of Substitution (DS), moisture content, and heavy metal analysis. A higher DS usually indicates better water solubility and bioactivity. We provide a 3rd-party test report for every batch.
Is it safe for sensitive skin?
Yes, it is highly biocompatible and non-irritating. Its natural origin and film-forming properties actually help soothe and protect the skin barrier.
References
1.Muzzarelli, R. A. (1988). "Carboxymethyl chitosan and its applications." Chitin in Nature and Technology.
2.Chen, X. G., et al. (2003). "Preparation and characterization of water-soluble chitosan derivatives." Biomaterials.
3.Lin, Y. H., et al. (2007). "Preparation and characterization of nanoparticles based on carboxymethyl chitosan for drug delivery." Journal of Controlled Release.
4.Upadhyaya, L., et al. (2013). "Carboxymethyl chitosan-mediated synthesis of gold nanoparticles." Carbohydrate Polymers.
5.European Medicines Agency (EMA). "Guideline on the use of chitosan in pharmaceutical products."
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