Gynostemma pentaphyllum saponins
Gynostemma Pentaphyllum Extract Manufacturer | 98% Gypenosides CAS: 11028-00-5 | The "Southern Ginseng" Adaptogen Standard: UV/HPLC Verified | Active Ingredient: Total Gypenosides Certifications: ISO9001, HACCP, Halal, Kosher, Non-GMO • High Potency: Standardized to ≥98% Gypenosides (Pharma Grade) & 80% (Nutra Grade). • Adaptogenic Power: Chemically similar to Ginseng but with broader saponin variety (over 80 types). • Dual Regulation: Supports healthy blood pressure and cholesterol levels. • Supply: Ready Stock in Xi'an | Commercial Batch Consistency.
Introduction
Gynostemma Pentaphyllum Extract, commonly known as Jiaogulan or "Southern Ginseng," is derived from the aerial parts of the climbing vine native to Southern China. It is revered in Traditional Chinese Medicine (TCM) as an "immortality herb."
The primary bioactive compounds are Gypenosides (Saponins). Remarkably, several Gypenosides (e.g., Gypenoside III, IV, VIII) are identical in chemical structure to Ginsenosides found in Panax Ginseng (Rb1, Rb3, Rd). However, Gynostemma contains a wider variety of saponins (over 80 identified) compared to Ginseng, offering a cost-effective yet potent Adaptogenic solution for stress management and metabolic health.
Category：
Keywords：
ginseng
gypenosides
Functions
1.Cardiovascular Health (Lipid & BP Regulation)
• Lipid Lowering: Clinical studies suggest Gypenosides help lower LDL cholesterol and triglycerides while raising HDL, preventing atherosclerosis.
• Blood Pressure: It stimulates the release of Nitric Oxide (NO), inducing vasodilation and helping to normalize blood pressure (works for both hypotension and hypertension).
2.Adaptogenic & Anti-Stress
• Biphasic Effect: Like Ginseng, it acts as a biological response modifier. It calms the nervous system when overexcited and stimulates it when fatigued, helping the body adapt to physical and mental stress.
3.Antioxidant & Immunity
• SOD Booster: Increases the production of endogenous superoxide dismutase (SOD), protecting cells from oxidative damage and aging.
• Immune Modulation: Enhances macrophage activity and white blood cell counts.
Applications
Dietary Supplements:
• Heart Health Formulas: Capsules for cholesterol management and hypertension support.
• Energy & Stress Relief: Often blended with Rhodiola or Ashwagandha in adaptogen complexes.
Functional Beverages:
• Herbal Teas: Used in ready-to-drink (RTD) teas for its natural sweet-bitter taste and health benefits.
Cosmetics:
• Anti-Hair Loss: Used in shampoos to promote scalp circulation.
• Anti-Aging: Added to creams for its antioxidant properties.
Animal Nutrition:
• Feed Additive: Improves immunity and meat quality in livestock.
Flow Chart
1.Harvesting: Selection of mature Gynostemma pentaphyllum leaves (Fall harvest).
2.Drying & Milling: Sun-drying and grinding to coarse powder.
3.Extraction: Reflux extraction with Water/Ethanol mixture.
4.Filtration: Removal of plant fibers.
5.Purification (Macroporous Resin): Critical step to enrich Saponins and remove impurities.
6.Concentration: Vacuum evaporation.
7.Spray Drying: Conversion to fine powder.
8.Sieving (80 Mesh) & Packaging: Metal detection and final packing.
Quality Standard of Lactoferrin
Product: Gynostemma Extract (Gypenosides 98%)
| Item | Specification | Result |
| Appearance | Light yellow to brownish-yellow powder | Conforms |
| Odor | Characteristic, slightly bitter-sweet | Conforms |
| Assay (Total Gypenosides) | ≥ 98.0% (UV) | 98.4% |
| Gypenoside A | Identification Positive | Conforms |
| Loss on Drying | ≤ 5.0% | 3.2% |
| Ash | ≤ 5.0% | 2.5% |
| Heavy Metals (Total) | ≤ 10 ppm | < 10 ppm |
| Pesticide Residues | USP/EP Standard | Conforms |
| Microbiology | Total Plate Count < 1000 CFU/g | Conforms |
Note: 80% and 40% grades are also available for cost-sensitive formulations.
Method of Analysis of Lactoferrin
• Total Saponins: UV-Vis Spectrophotometry is the industry standard for "Total Gypenosides" (using Ginsenoside Re as a standard).
• Specific Saponins: HPLC is used to identify specific marker compounds (like Gypenoside XLIX or Ginsenoside Rb1) to verify authenticity and rule out adulteration.
Reference Chromatogram of Lactoferrin Reference Substance
(Image Placeholder: HPLC Fingerprint of Gynostemma Extract)
The chromatogram reveals a complex peak profile. The presence of peaks matching Ginsenoside Rb1 and Rd confirms the unique "Ginseng-like" chemistry of Gynostemma, distinguishing it from other common herbal saponins.
Stability and Safety
Stability Studies
• Hygroscopicity: High purity saponins are hygroscopic.
• Stability Data: Stable for 24 months when stored in sealed, double-layer PE bags inside fiber drums.
• Conditions: Must be kept away from moisture. Exposure to humidity causes the powder to cake and darken.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous botanical extract.
• Safety: Generally considered safe (GRAS equivalent in traditional use).
• Side Effects: High doses taken on an empty stomach may cause mild nausea or increased bowel movements.
Customer Comments
Product Developer, Herbal Drink Co., Japan
2026.02.13
★★★★☆
Sourcing Manager, Supplement Brand, USA
2026.02.13
★★★★☆
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FAQ
How does Gynostemma compare to Panax Ginseng?
Gynostemma contains Gypenosides, many of which are chemically identical to Ginsenosides. While Ginseng is warming and stimulating (Yang), Gynostemma is considered more balanced or slightly cooling (Yin/Yang neutral), making it suitable for daily use without causing "overheating."
Is it water soluble?
Yes, our 98% Gypenosides extract has excellent water solubility, making it ideal for beverages, tinctures, and liquid shots. Lower purity grades (e.g., 20%) may have some insolubles.
Does it contain caffeine?
No, Gynostemma is naturally caffeine-free. Its energy-boosting effect comes from improved metabolic efficiency and oxygen utilization, not central nervous system stimulation.
References
1.Müller, C., et al. (2012). Gypenosides: A review of the pharmacology and therapeutic potential of Gynostemma pentaphyllum. Phytochemistry Reviews.
2.Huyen, V. T., et al. (2010). Gynostemma pentaphyllum tea improves insulin sensitivity in type 2 diabetic patients. Hormone and Metabolic Research.
3.Tanner, M. A., et al. (1999). The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum. Nitric Oxide.
4.Megalli, S., et al. (2005). Anti-hyperlipidemic and hypoglycemic effects of Gynostemma pentaphyllum in the Zucker fatty rat. Journal of Pharmacy & Pharmaceutical Sciences.
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