Jujube Seed Saponins
Jujube Seed Extract Manufacturer | Standardized Saponins (Jujubosides) CAS: 55466-05-2 | The "Oriental Sleeping Fruit" for Insomnia Relief Source: Ziziphus jujuba var. spinosa Seeds | Active Markers: Jujuboside A & B Certifications: ISO9001, HACCP, Halal, Kosher, Non-GMO • Natural Sedative: Clinically recognized for improving sleep quality without drowsiness. • Standardized Potency: Available in 2% Total Saponins (UV) and 0.2%-2% Jujuboside A (HPLC). • Mechanism: Modulates GABAergic systems to calm nervous activity. • Supply: Ready Stock in Xi'an | Consistent Batch-to-Batch Quality.
Introduction
Jujube Seed Extract (Semen Ziziphi Spinosae) is derived from the dried mature seeds of the Wild Jujube tree (Ziziphus jujuba var. spinosa). In Traditional Chinese Medicine (TCM), it is the premier herb for "nourishing the heart and quieting the spirit" (An Shen), used for centuries to treat insomnia and anxiety.
Modern pharmacology identifies Jujube Seed Saponins (Jujubosides) as the primary bioactive components responsible for its sedative and hypnotic effects. Unlike synthetic sleeping pills or melatonin, our extract works holistically to reduce sleep latency and extend deep sleep duration without disrupting the body's natural hormonal balance.
Category：
Keywords：
jujube
jujubosides
saponins
Functions
1.Sleep Support & Insomnia Relief (Key USP)
• GABA Modulation: Jujubosides (specifically Jujuboside A) act on the hippocampus, potentiating the effect of Gamma-Aminobutyric Acid (GABA), the brain's main inhibitory neurotransmitter. This calms neuronal excitability and induces natural sleep.
• Clinical Benefit: Reduces the time taken to fall asleep (sleep latency) and increases non-REM (deep) sleep.
2.Anti-Anxiety & Stress Relief
• Anxiolytic Effect: Flavonoids (Spinosin) and Saponins in the extract work synergistically to lower cortisol levels and alleviate symptoms of palpitations, anxiety, and nervous exhaustion.
3.Neuroprotection
• Cognitive Support: Studies suggest Jujubosides protect neuronal cells from oxidative stress and beta-amyloid toxicity, potentially supporting memory and cognitive function in aging populations.
Applications
Dietary Supplements (Sleep Aids):
• Natural Sleep Capsules: Often combined with Valerian Root, GABA, or Magnesium for a comprehensive "Sleep Support" formula.
• Stress Relief Blends: Used in daytime "Calm" supplements (lower dosage) to reduce anxiety without sedation.
Functional Beverages:
• Night-time Teas: Soluble powder suitable for functional tea mixes targeting relaxation.
Pharmaceuticals:
• TCM Preparations: Raw material for patent medicines treating neurasthenia and insomnia.
Flow Chart
1.Raw Material: Selection of plump, mature Ziziphus spinosa seeds (Shell cracked).
2.Cleaning: Removal of impurities and residual fruit pulp.
3.Extraction: Reflux extraction with 70% Ethanol to maximize Saponin yield.
4.Filtration & Concentration: Vacuum evaporation to remove ethanol.
5.Purification (Resin Column): Critical step to remove sugars and enrich Total Saponins/Jujubosides.
6.Spray Drying: Conversion to fine brown powder.
7.Sieving (80 Mesh): Ensuring uniform particle size.
8.Testing: HPLC analysis for Jujuboside A and B content.
Quality Standard of Lactoferrin
Product: Jujube Seed Extract (Total Saponins 2%)
| Item | Specification | Result |
| Appearance | Brown to reddish-brown fine powder | Conforms |
| Odor | Characteristic, slightly nutty/bitter | Conforms |
| Total Saponins (UV) | ≥ 2.0% | 2.4% |
| Jujuboside A (HPLC) | ≥ 0.1% (or Custom: 2%) | 0.15% |
| Loss on Drying | ≤ 5.0% | 3.8% |
| Ash | ≤ 5.0% | 3.1% |
| Heavy Metals (Pb) | ≤ 2.0 ppm | 0.8 ppm |
| Arsenic (As) | ≤ 1.0 ppm | Not Detected |
| Microbiology | Total Plate Count < 1000 CFU/g | Conforms |
Note: We also supply Spinosin standardized extracts (0.1% - 2% HPLC) upon request.
Method of Analysis of Lactoferrin
• Total Saponins: UV-Vis Spectrophotometry (using Jujuboside A standard).
• Specific Markers: HPLC-ELSD (Evaporative Light Scattering Detector) is used to accurately quantify Jujuboside A and Jujuboside B, as they have weak UV absorption. This ensures you are getting the authentic active ingredient, not just generic saponins.
Reference Chromatogram of Lactoferrin Reference Substance
(Image Placeholder: HPLC-ELSD Chromatogram of Jujube Seed Extract)
The chromatogram shows distinct peaks for Jujuboside A and Jujuboside B. A secondary peak for Spinosin (a flavonoid) is also typically present, confirming the "Full Spectrum" nature of the extract.
Stability and Safety
Stability Studies
• Hygroscopicity: The extract is moderately hygroscopic.
• Storage: Store in tightly sealed containers in a cool, dry place away from direct sunlight.
• Shelf Life: 24 months.
Safety & Handling (MSDS Summary)
• Classification: GRAS (Food Supplement).
• Toxicity: Low toxicity. No adverse effects reported at standard dosages (200-500mg).
• Interactions: May enhance the effect of sedative medications (benzodiazepines).
Customer Comments
Product Developer, Natural Health Brand, Australia
2026.02.12
★★★★☆
R&D Manager, Functional Beverage Co., USA
2026.02.12
★★★★☆
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FAQ
What is the effective dosage for sleep?
For a 2% Total Saponins extract, the typical dosage is 250mg to 500mg, taken 30-60 minutes before bedtime.
Does it cause grogginess the next morning?
No. Unlike antihistamines or some prescription sedatives, Jujube Seed Extract promotes relaxation and natural sleep cycles, typically resulting in a refreshed feeling upon waking without the "hangover" effect.
Is it standardized to Jujuboside A or B?
Our standard spec is Total Saponins (UV). However, for premium formulations, we can standardize to Jujuboside A + B (HPLC). Please specify your preference in your inquiry.
References
1.Shergis, J. L., et al. (2017). Ziziphus spinosa seeds for insomnia: A review of chemistry and psychopharmacology. Phytomedicine.
2.Jiang, J. G., et al. (2007). Comparison of the sedative and hypnotic effects of flavonoids, saponins, and polysaccharides extracted from Semen Ziziphus jujube. Natural Product Research.
3.Cao, J. X., et al. (2010). Hypnotic effect of jujubosides from Semen Ziziphi Spinosae. Journal of Ethnopharmacology.
4.Chen, C. Y., et al. (2011). Jujuboside A inhibits excitatory hippocampal signaling... implying a mechanism for its sedative effect. Journal of Natural Medicines.
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