NRC
Nicotinamide Riboside Chloride (NRC) Manufacturer | NAD+ Booster (CAS: 1341-23-7) Headline: chief Nicotinamide Riboside Chloride (NRC) Manufacturer | 99% Purity NAD+ Precursor (CAS: 1341-23-7) Sub-info: Validated Crystal Form | High Bioavailability | Third-Party Tested (NMR/HPLC) USP: Ready Stock in US/EU | Novel Food Compliant Standard | Non-Hygroscopic Stable Form
Introduction
Nicotinamide Riboside Chloride (NRC) is a cutting-edge pyridine-nucleoside shape of Vitamin B3, acting as a powerful antecedent to Nicotinamide Adenine Dinucleotide (NAD+). Not at all like Niacin (Vitamin B3) or Nicotinamide, NRC does not cause skin flushing and utilizes a one of a kind metabolic pathway (NRK) to productively lift cellular NAD+ levels.
As a specialized producer, we synthesize high-purity NRC (Chloride frame) outlined for most extreme soundness and bioavailability in dietary supplements and useful definitions. Our item addresses the common industry torment point of debasement, advertising a stabilized crystalline powder reasonable for capsules and drink mixes.
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Functions
NRC is scientifically recognized for its role in cellular energy metabolism and longevity.
1. Efficient NAD+ Restoration (MOA):
NRC enters cells via specific nucleoside transporters and is phosphorylated by Nicotinamide Riboside Kinase (NRK) to form NMN, which is then converted to NAD+. This "Salvage Pathway" shortcut bypasses the rate-limiting steps of other B3 vitamins.
2. Mitochondrial Biogenesis:
By boosting NAD+, NRC activates Sirtuins (SIRT1 & SIRT3), enzymes crucial for mitochondrial function, potentially reversing age-related mitochondrial decline.
3. Neuroprotection:
Research indicates NRC supports neuronal health by maintaining axonal NAD+ levels, protecting against excitotoxicity and oxidative stress.
4. Metabolic Health:
Studies suggest NRC supplementation supports healthy insulin sensitivity and lipid metabolism in high-fat diet models.
Applications
• Anti-Aging Supplements: Primary ingredient in "Longevity" and "DNA Repair" capsules (often paired with Resveratrol or Pterostilbene).
• Sports Nutrition: Formulated into pre-workout powders to enhance muscle recovery and cellular energy (ATP) production.
• Nootropics: Cognitive support formulas targeting focus and brain energy.
• Cosmeceuticals: Emerging application in topical serums for skin cellular repair (requires specific formulation stabilization).
Flow Chart
Pharmaceutical-Grade Synthesis Process:
1.Reaction: Ribose derivative + Nicotinamide derivative coupling.
2.Deprotection: Removal of protective groups to release Nicotinamide Riboside.
3.Salt Formation: Reaction with Chloride to form the stable Chloride salt.
4.Crystallization: Controlled cooling to induce specific crystal lattice (Critical for stability).
5.Purification: Recrystallization to remove isomers and impurities.
6.Drying: Vacuum drying at low temperature.
7.Milling & Sieving: To ensure uniform particle size (e.g., 80 mesh).
8.QC & Packing: Double PE bags in fiber drums (Nitrogen flushed).
Quality Standard of Lactoferrin
Spec: Nicotinamide Riboside Chloride >99%
| Item | Specification | Result |
| Active Ingredient | Nicotinamide Riboside Chloride (HPLC) | ≥ 99.0% |
| Appearance | White to Off-white Crystalline Powder | Conforms |
| Identification | H-NMR / HPLC | Conforms |
| Water Content | ≤ 1.0% | 0.4% |
| Specific Rotation | +21.0° ~ +24.0° | +22.5° |
| Residual Solvents | Ethanol ≤ 5000ppm (USP <467>) | < 500ppm |
| Heavy Metals | ≤ 10 ppm | < 5 ppm |
| Lead (Pb) | ≤ 0.5 ppm | 0.05 ppm |
| Arsenic (As) | ≤ 0.5 ppm | 0.02 ppm |
| Microbiology | Total Plate Count ≤ 1,000 cfu/g | Conforms |
Method of Analysis of Lactoferrin
• Assay: HPLC (High-Performance Liquid Chromatography) on a C18 column with UV detection at 254nm.
• Identification: 1H-NMR (Nuclear Magnetic Resonance) is used to confirm the molecular structure and exclude stereoisomers.
• Why this matters: Ensures you are receiving the bioactive Beta-anomer, not the inactive Alpha-anomer.
Reference Chromatogram of Lactoferrin Reference Substance
(Description): The chromatogram displays a single dominant peak at the retention time of approx 5.2 min. No significant peaks observed for reactants (Nicotinamide) or degradation products (Ribose), confirming high purity (>99% Area Normalization).
Stability and Safety
Stability Studies
• Challenge: NRC is historically unstable in moisture.
• Solution: Our Crystalline Chloride form is optimized for stability.
• Data:
◉ Long-term (4°C / Refrigerated): 24 months. Purity remains >98.5%.
◉ Accelerated (25°C / 60% RH): 6 months. Purity remains >98.0%.
◉ Stress Test (40°C / 75% RH): Significant degradation observed after 30 days. Conclusion: Product requires cold chain storage or strictly controlled cool/dry warehousing.
Safety & Handling (MSDS Summary)
• Classification: Not classified as hazardous for transport.
• GRAS Status: Generally Recognized As Safe in the USA for use in food supplements.
• Handling: Hygroscopic. Minimize exposure to air. Handle in dehumidified environment (<40% RH recommended).
• Storage: "Keep Refrigerated (2-8°C)" recommended for long-term storage to maximize potency.
Customer Comments
Plant Manager, California Supplement Co.
2026.02.11
★★★★★
Sourcing Director, UK Biotech Firm
2026.02.11
★★★★★
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FAQ
What is the difference between NRC and NMN?
Both are NAD+ precursors. NRC (Nicotinamide Riboside) is a nucleoside that requires one step (phosphorylation) to become NMN, which then becomes NAD+. NRC is often smaller in molecular weight, which influences its transport mechanism into cells.
Is your NRC synthetic or natural?
Our NRC is produced via a patented enzymatic/chemical synthesis process. This ensures identical molecular structure to the trace amounts found in milk, but with the high purity and scalability required for industrial use.
Does NRC require cold chain shipping?
For short-term transit (up to 2 weeks), the chloride salt form is stable at ambient temperature. However, we recommend refrigerated storage upon receipt and offer cold-chain shipping options for premium assurance during summer months.
References
1.Trammell, S. A., et al. (2016). "Nicotinamide riboside is uniquely and orally bioavailable in mice and humans." Nature Communications.
2.Bieganowski, P., & Brenner, C. (2004). "Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans." Cell.
3.Airhart, S. E., et al. (2017). "An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers." PLoS One.
4.Conze, D., et al. (2019). "Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults." Scientific Reports.
5.Martens, C. R., et al. (2018). "Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults." Nature Communications.
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