Madecassoside
Madecassoside Manufacturer | High-Purity Centella Asiatica Extract (CAS: 18449-41-7) Headline: Premium Madecassoside Manufacturer | 90% High-Purity Skin Repair Active (CAS: 18449-41-7) Sub-info: Derived from Centella asiatica | USP/EP Standard | ISO & FDA Registered Facility USP: Ready Stock in US/EU | Clinically Proven Anti-Inflammatory Efficacy | Full Batch Traceability
Introduction
Madecassoside (CAS: 18449-41-7) is one of the four primary triterpene saponins found in the medicinal plant Centella asiatica (Gotu Kola). Chemically classified as a pentacyclic triterpene, it is widely recognized as the most effective bioactive component for dermal repair and skin barrier restoration.
As a professional B2B manufacturer, we provide High-Purity Madecassoside Powder (90%) through advanced isolation technology. Unlike crude Centella extracts, our standardized Madecassoside offers precise potency for high-end cosmeceutical formulations, specifically targeting wound healing, collagen synthesis, and chronic skin inflammation.
Category：
Keywords：
asiatica
centella
kaempferol
Functions
Madecassoside is renowned for its ability to modulate the skin's healing process.
1.Potent Anti-Inflammatory Mechanism (MOA):
Madecassoside inhibits the expression of pro-inflammatory cytokines, such as Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor-α (TNF-α). It works by suppressing the NF-κB signaling pathway, making it an ideal treatment for sensitive, irritated, or post-procedure skin.
2.Collagen Type I & III Synthesis:
It acts on dermal fibroblasts to stimulate the production of Collagen Type I and Type III. This dual action not only helps in rapid wound healing but also provides significant anti-aging benefits by restoring the skin's structural density.
3.Skin Barrier Restoration:
It enhances the expression of filaggrin and involucrin, essential proteins for maintaining a healthy stratum corneum, thereby reducing transepidermal water loss (TEWL).
4.Antioxidant Defense:
Scavenges free radicals induced by UV radiation, protecting skin cells from oxidative stress and premature photoaging.
Applications
• Post-Procedure Repair Creams: Used in "Cica" creams for recovery after laser treatments or chemical peels.
• Anti-Aging Serums: Targeted at reducing deep wrinkles and improving skin elasticity.
• Sensitive Skin Care: Formulated into lotions and essences to soothe redness and chronic irritation.
• Wound Healing Ointments: Pharmaceutical-grade applications for scar reduction and tissue regeneration.
Flow Chart
High-Efficiency Extraction & Purification Process:
1.Harvesting: Selection of premium Centella asiatica leaves with high triterpene content.
2.Extraction: Low-temperature solvent extraction to preserve molecular bioactivity.
3.Filtration: Removal of plant fibers and insoluble pigments.
4.Chromatographic Separation: Advanced macroporous resin and HPLC-level separation to isolate Madecassoside from Asiaticoside.
5.Concentration: Vacuum evaporation to maintain stability.
6.Crystallization: Induction of white crystalline powder form.
7.Drying & Sifting: Vacuum drying and 80-mesh sifting for uniform particle size.
Quality Standard of Lactoferrin
Spec: Madecassoside 90% (Cosmetic/Pharma Grade)
| Item | Specification | Result |
| Assay (HPLC) | ≥ 90% | 92.35% |
| Appearance | White Powder | Conforms |
| Identification | TLC | Conforms |
| Loss on Drying | ≤ 3.0% | 0.52% |
| Ash | ≤ 1.0% | 0.24% |
| Heavy Metals | ≤ 20 ppm | Conforms |
| Lead (Pb) | ≤ 0.5 ppm | Conforms |
| Arsenic (As) | ≤ 0.5 ppm | Conforms |
| Total bacteria count | ≤ 1,000 cfu/g | Conforms |
| Yeast/moulds | ≤ 1,00 cfu/g | Conforms |
| Salmonella | Negative | Conforms |
| E-Coli | Negative | Conforms |
Method of Analysis of Lactoferrin
• Analytical Method: High-Performance Liquid Chromatography (HPLC).
• Why it matters: We use a C18 column with a water/acetonitrile gradient. This method accurately distinguishes Madecassoside from Asiaticoside B and other isomers, ensuring that you receive the specific bioactive compound required for your formulation’s claims.
Reference Chromatogram of Lactoferrin Reference Substance
(Description): A high-quality chromatogram for Madecassoside shows a sharp, symmetrical peak at the target retention time. Impurity control is strictly maintained, with Asiaticoside levels kept within specified limits to ensure the anti-inflammatory potency of the Madecassoside fraction.
Stability and Safety
Stability Studies
• Shelf Life: 24-month (2-year) shelf life supported by real-time stability data.
• Long-term Stability: Samples stored at 25°C ± 2°C / 60% ± 5% RH maintained Appearance, Purity, and Water Content within specifications for 24 months.
• Accelerated Stability: 6-month data (40°C ± 2°C / 75% ± 5% RH) confirms the product remains stable during international shipping and variable warehouse conditions.
• Consistency: Tested parameters are fully consistent with the Module 6 Quality Standard.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous. Does not carry a hazard classification according to EEC directives.
• Handling: Wear safety glasses and masks to prevent dust inhalation. Use in a well-ventilated area.
• Storage: Store in a cool, dry place; keep container tightly closed. Protect from direct sunlight and moisture.
Customer Comments
R&D Director, French Cosmeceutical Brand
2026.02.04
★★★★☆
Formulation Manager, German Skincare Lab
2026.02.04
★★★★☆
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FAQ
What is Madecassoside?
It is a high-purity active ingredient (triterpene saponin) extracted from Centella asiatica, specifically targeted for skin repair and inflammation control.
What is the Mechanism of Action?
It works by suppressing NF-κB-mediated inflammation and stimulating the TGF-β pathway to accelerate collagen synthesis and tissue regeneration.
How do you identify quality?
Quality is validated through HPLC Purity (≥90%), standardized color (pure white), and a comprehensive impurity profile. Every batch is supplied with a detailed COA.
References
1.Maquart, F. X., et al. (1999). "Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds." European Journal of Dermatology.
2.Lee, J. H., et al. (2010). "Anti-inflammatory effects of madecassoside on skin inflammation." Journal of Dermatological Science.
3.Haftek, M., et al. (2008). "Clinical improvement of photoaged skin with a Madecassoside-containing formulation." Dermatology.
4.Lu, L., et al. (2004). "Madecassoside promotes wound healing through the synthesis of collagen." Planta Medica.
5.European Medicines Agency (EMA). "Assessment report on Centella asiatica (L.) Urban, herba."
6.Bylka, W., et al. (2013). "Centella asiatica in cosmetology." Postepy Dermatologii i Alergologii.
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