Kaempferol
Kaempferol Manufacturer | Potent Flavonoid & Kidney Health (CAS: 520-18-3) Source: Sophora japonica (Flower) / Kaempferia galanga | Purity: ≥98% (HPLC) | Certifications: ISO9001, Kosher, Halal, Non-GMO USP: Natural Phytoestrogen | High Bioactivity | Ready Stock in Local Warehouse
Introduction
Kaempferol (CAS: 520-18-3; Chemical Formula: C15H10O6) is a natural flavonol present in various plants—including Sophora japonica, tea, broccoli, and grapefruit. It shows up as a bright yellow crystalline powder and is structurally close to Quercetin, with just one hydroxyl group difference between them.
As a powerful polyphenol, kaempferol has gained strong interest in the nutraceutical and pharmaceutical industries. It supports bone health by stimulating osteoblasts, protects kidney function, and can regulate cellular signaling pathways linked to inflammation and oxidative stress.
Category：
Keywords：
kaempferol
natural
sophora
Functions
1.Bone Health (Osteoporosis Prevention)
Kaempferol has proven effective at stimulating osteoblastic differentiation while inhibiting osteoclastic bone resorption. By boosting the expression of osteogenic markers (such as RUNX2 and Osterix), it helps maintain bone density—making it a key ingredient in menopausal health products.
2.Kidney Protection
Research shows kaempferol shields renal cells from oxidative damage (e.g., cisplatin-induced nephrotoxicity). It works by activating the Nrf2 signaling pathway and reducing the buildup of reactive oxygen species (ROS) in kidney tissues.
3.Anti-Inflammatory & Antioxidant
It effectively blocks the release of pro-inflammatory cytokines (IL-6, TNF-α) and lowers the activity of enzymes like COX-2. Its antioxidant properties also help reduce cellular damage caused by environmental stressors.
4.Anticancer Potential (Research)
In vitro studies suggest kaempferol induces apoptosis in various cancer cell lines (ovarian, breast, lung) by regulating angiogenesis and metastasis pathways. That said, it’s primarily marketed for its preventive health benefits right now.
Applications
• Dietary Supplements: Formulated into capsules for Bone Health (often paired with Calcium/Vitamin D) and Kidney Support.
• Functional Foods: Used as a natural antioxidant and preservative in lipid-rich foods to prevent rancidity.
• Pharmaceuticals: Investigated as an API intermediate for drugs targeting osteoporosis and chronic inflammation.
• Cosmetics: Added to anti-aging creams for its ability to inhibit metalloproteinases (MMPs), which in turn reduces collagen degradation.
Flow Chart
Our extraction process from Sophora japonica ensures high purity and environmental compliance,following these steps:
1.Raw Material: Dried Sophora japonica flowers.
2.Extraction: Ethanol/Water reflux extraction.
3.Hydrolysis: Acid hydrolysis to convert glycosides (e.g., Kaempferin) into kaempferol aglycone.
4.Filtration & Concentration: Removing impurities and recovering solvent.
5.Crystallization: Controlled cooling crystallization to isolate Kaempferol.
6.Purification: Recrystallization to achieve over 98% purity.
7.Drying: Vacuum drying to produce a fine yellow powder.
Quality Standard of Lactoferrin
Product: Kaempferol 98%
CAS No.: 520-18-3
| Item | Specification | Result |
| Appearance | Yellow crystalline powder | Conforms |
| Assay (HPLC) | ≥98.0% | 98.4% |
| Melting Point | 276°C – 278°C | 277.1°C |
| Loss on Drying | ≤1.0% | 0.4% |
| Ash Content | ≤0.2% | 0.08% |
| Heavy Metals (Pb) | ≤10 ppm | < 5 ppm |
| Arsenic (As) | ≤2 ppm | < 1 ppm |
| Solubility | Soluble in hot ethanol, ether | Conforms |
| Microbiology | Total Plate Count < 1000 CFU/g | Conforms |
Method of Analysis of Lactoferrin
• HPLC: The gold standard for purity testing.
• Column: C18 Reverse Phase
• Mobile Phase: Methanol : 0.4% Phosphoric Acid (Gradient or Isocratic)
• Detector: UV at 370 nm
• Why HPLC? It separates kaempferol from structurally similar flavonoids like Quercetin, ensuring you get the exact active ingredient you need.
Reference Chromatogram of Lactoferrin Reference Substance
The chromatogram shows a single, sharp peak for kaempferol at a retention time of ~10-12 minutes. Impurities like Quercetin are usually undetectable or below 0.5% in our high-purity grade.
Stability and Safety
Kaempferol is a crystalline powder at room temperature, with a melting point around 276°C. It has good thermal stability, but its solution form is unstable—avoid light and high temperatures to prevent degradation. Store in a cool, dry place.
When handling, follow chemical safety guidelines: avoid inhaling dust, keep away from skin and eyes, and operate in a fume hood.
Stability Studies
• Shelf Life: 24 months.
• Conditions: Chemically stable, but susceptible to oxidation if exposed to air/light for extended periods.
• Data: Samples stored in double-lined PE bags inside fiber drums at 25°C showed no significant degradation over 2 years.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance for transport.
• Toxicity: Low oral toxicity (LD50 > 5000 mg/kg in rats).
• Mutagenicity: Ames test negative at typical supplement dosages.
• Storage: Store in a cool, dry place. Protect from light and moisture.
Customer Comments
Product Developer, Nutraceutical Co., UK
2026.02.04
★★★★☆
QA Manager, Supplement Brand, USA
2026.02.04
★★★★☆
Our Certificates
SKS-Kosher
CERTIFICATE
CERTIFICATE
ISO9001
ISO22000
FDA
Our Clients
Exhibitions
Meet Managers Ma Bin / Chen Pinfeng and our team at:
• Vitafoods Europe (Geneva)
• SupplySide West (Las Vegas)
• CPhI Worldwide
Vitafoods Europe (Geneva)
SupplySide West (Las Vegas)
CPhI Worldwide
In-Cosmetics Global
SupplySide West (Las Vegas)
CPHI & PMEC China 2025
CAC 24th
CAC Shanghai
CPHI & PMEC 2024
CPHI & PMEC China Shanghai
CPHI 2025
CPHI 2024
CPHI 2023
FIC 2022
FIC 2023
FIC Shanghai
FIC2024
CPHI Korea
SupplySideWEST Las Vegas
SupplySideWEST 2023
Vitafoods Europe Switzerland
Wagri Guangzhou
FAQ
What is the main difference between Kaempferol and Quercetin?
They are structurally very similar, but Kaempferol lacks one hydroxyl group at the C-3' position compared to Quercetin. This slight difference gives Kaempferol higher stability and distinct bioactivities, particularly in bone metabolism and adipogenesis inhibition.
Is your Kaempferol derived from Kaempferia galanga or Sophora japonica?
We primarily produce it from Sophora japonica due to the sustainable supply chain and higher purity achievable at an industrial scale. We can also source from Kaempferia galanga (Galangal) upon request for specific "Ginger Family" label claims.
Is it water soluble?
Kaempferol is slightly soluble in water but highly soluble in hot ethanol, methanol, and diethyl ether. For water-based beverages, we recommend using a solubility enhancer or nano-emulsion technology.
References
1.Calderón-Montaño, J.M., et al. (2011). "A review on the dietary flavonoid kaempferol." Mini Reviews in Medicinal Chemistry.
2.Wattanathorn, J., et al. (2012). "Kaempferol promotes bone formation in osteoblasts." Phytotherapy Research.
3.Chen, A.Y., et al. (2013). "A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention." Food Chemistry.
4.Devi, K.P., et al. (2015). "Kaempferol and inflammation: From chemistry to medicine." Pharmacological Research.
5.Imran, M., et al. (2019). "Kaempferol: A key emphasis to its anticancer potential." Molecules.
Related Products
Our Global Presence：Pioneer Biotech | Pioneer Bio Inc. | Kono Chem | Kono Chem (RU)
P&K INTERNATIONAL PTE. LTD.