Anserine
Anserine Manufacturer | Uric Acid Control & Anti-Fatigue Headline: Natural Anserine Manufacturer | Uric Acid Management & Sports Recovery (CAS: 584-85-0) Source : Extracted from Deep-Sea Fish/Poultry | High Purity Dipeptide | Clinically Supported Unique Selling Proposition (USP): • Uric Acid Regulation: Scientifically proven to lower uric acid levels by inhibiting re-absorption. • Potent Antioxidant: Protects cells from oxidative stress and reduces fatigue markers (lactic acid). • High Stability: Advanced extraction technology ensures peptide integrity and bioavailability.
Introduction
Anserine (β-alanyl-N-methylhistidine) is a highly stable histidine-containing dipeptide found naturally in the muscles of vertebrates, particularly in high concentrations in migratory birds and deep-sea fish (like Tuna and Bonito).
Unlike Carnosine, Anserine is methylated, which makes it more resistant to enzymatic degradation in human blood, allowing it to circulate longer and exert potent physiological effects. It is a premium functional ingredient widely used in anti-gout supplements and sports nutrition for its ability to buffer intramuscular pH and manage uric acid metabolism.
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dipeptide
Functions
1.Uric Acid Management (Anti-Gout)
• Mechanism: Inhibits the activity of Urate Transporter 1 (URAT1).
• Action: Reduces the re-absorption of uric acid in the kidneys, facilitating its excretion and helping to maintain healthy serum uric acid levels.
2.Anti-Fatigue & Performance
• Mechanism: Acts as a pH buffer in skeletal muscle.
• Action: Neutralizes lactic acid accumulation during high-intensity exercise, delaying muscle fatigue and improving endurance performance (often utilized by marathon runners and triathletes).
3.Cognitive Protection
• Mechanism: Reduces oxidative stress and inflammation in the brain.
• Action: Studies suggest potential neuroprotective effects, preserving memory and cognitive function in aging populations.
Applications
1.Uric Acid Support Supplements
• Application: Capsules or tablets combined with Vitamin C or Tart Cherry Extract.
Directly addresses the biochemical pathway of uric acid excretion, offering a natural alternative for gout management.
2.Sports Nutrition
• Application: Pre-workout powders and recovery gels.
Its resistance to carnosinase (the enzyme that breaks down carnosine) means it stays active in the body longer, supporting prolonged physical exertion.
3.Functional Beverages
• Application: Ready-to-drink (RTD) energy or wellness shots.
Water-soluble and stable in liquid formulations.
Flow Chart
1.Raw Material: Selection of Tuna/Bonito extract or Poultry source.
2.Extraction: Hot water extraction to solubilize peptides.
3.Filtration: Removal of fats and insoluble proteins.
4.Purification: Ultrafiltration and chromatography to isolate Anserine from other amino acids.
5.Concentration: Vacuum evaporation.
6.Crystallization/Drying: Spray drying or freeze drying to produce powder.
7.Sieving: Passing through 80 mesh.
8.Packaging: 1kg/Bag or 25kg/Drum.
Quality Standard of Lactoferrin
Product: Anserine Powder
Source: Tuna/Bonito Extract (Marine Source)
| Item | Specification | Result |
| Appearance | White to off-white powder | Conforms |
| Anserine Content | ≥ 85% (Customizable) | 94.2% |
| Loss on Drying | ≤ 6.0% | 4.32% |
| Ash | ≤ 8.0% | 4.5% |
| pH (1% solution) | 6.5 - 8.5 | 7.4 |
| Heavy Metals (Pb) | ≤ 1.0 ppm | < 0.5 ppm |
| Arsenic (As) | ≤ 0.5 ppm | < 0.2 ppm |
| Total Plate Count | ≤ 1,0000 cfu/g | ＜10 |
Method of Analysis of Lactoferrin
Test Method: HPLC (High-Performance Liquid Chromatography)
• Column: C18 Reverse Phase or specialized HILIC column for polar peptides.
• Detector: UV at 210-220 nm.
• Standard: Sigma-Aldrich Certified Anserine Standard.
• Validation: Separation from Carnosine is critical; our method ensures no co-elution, guaranteeing accurate assay values.
Reference Chromatogram of Lactoferrin Reference Substance
(Description)
The HPLC chromatogram clearly resolves the peaks for Carnosine and Anserine. Anserine typically elutes after Carnosine in reverse-phase systems due to the methyl group increasing hydrophobicity. A clean baseline indicates the absence of peptide degradation products.
Stability and Safety
Stability Studies
• Long-term Stability (24 Months): Stored at 25°C/60% RH. Assay decreased by < 2% over 2 years.
• Thermal Stability: Anserine is heat stable, making it suitable for pasteurized beverages.
• Conclusion: 2-year shelf life verified.
Safety & Handling (MSDS Summary)
• Classification: Food Ingredient / GRAS (Self-affirmed).
• Allergens: Fish (if marine sourced). Must be labeled. Poultry source available for allergen-free requirements.
• Handling: Standard PPE (mask, gloves).
• Storage: Store in a cool, dry place. Hygroscopic – keep tightly sealed.
Customer Comments
R&D Director, GoutLess Pharma (USA)
2026.03.04
★★★★☆
Product Developer, AquaLife (Germany)
2026.03.04
★★★★☆
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FAQ
What is the difference between Anserine and Carnosine?
Anserine is methylated Carnosine. This methylation makes Anserine more stable against the enzyme carnosinase in human blood, allowing it to stay in circulation longer.
What is the effective dosage?
For uric acid management, studies typically use 50mg to 150mg of pure Anserine per day.
Is it safe for seafood allergies?
If sourced from Tuna/Bonito, it carries a fish allergen warning. We also offer Chicken-sourced Anserine for customers requiring non-fish options.
References
1.Kubomura, D., et al. (2016). "Effect of Tuna Extract on Serum Uric Acid Levels in Subjects with Mild Hyperuricemia." Integrative Molecular Medicine.
2.Derave, W., et al. (2010). "Muscle Carnosine Metabolism and beta-alanine supplementation in relation to exercise and training." Sports Medicine.
3.Suzuki, Y., et al. (2006). "High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting." Japanese Journal of Physiology.
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