D-salicin
D-Salicin Manufacturer | Natural Analgesic API (CAS: 138-52-3) Source: Salix alba (White Willow) Bark | Purity: ≥98% (HPLC) | Certifications: GMP, ISO9001, Kosher, Halal USP: Natural Aspirin Precursor | Gentle on Stomach | Ready Stock in US/EU
Introduction
D-Salicin (CAS: 138-52-3; Chemical Formula: C₁₃H₁₈O₇) is a naturally occurring alcoholic beta-glucoside extracted from the bark of the White Willow (Salix alba). Often referred to as "Nature's Aspirin," it is the metabolic precursor to salicylic acid.
Unlike synthetic aspirin (acetylsalicylic acid) which can damage the gastric mucosa, D-Salicin is converted into salicylic acid only after being absorbed and metabolized by the liver. This unique pharmacokinetics allows it to provide potent anti-inflammatory and analgesic effects without the common side effect of stomach irritation.
Category：
Keywords：
activator
chinensis
Functions
1.Natural Analgesic (Pain Relief)
D-Salicin inhibits the activity of Cyclooxygenase (COX-1 and COX-2) enzymes, reducing the production of prostaglandins which are the mediators of pain and inflammation. It is effective for headaches, back pain, and osteoarthritis.
2.Anti-Inflammatory
By modulating inflammatory pathways, D-Salicin reduces swelling and joint stiffness. It is widely used in formulations targeting rheumatic conditions and sports injuries.
3.Antipyretic (Fever Reduction)
Acting on the hypothalamus heat-regulating center, it helps dissipate body heat and lower fever, making it a safe natural alternative in cold and flu remedies.
4.Cosmetic Applications (Exfoliation & Anti-Acne)
In cosmetics, Salicin acts as a precursor to Salicylic Acid (BHA). It provides gentle exfoliation, unclogs pores, and reduces acne-associated inflammation, making it ideal for "Clean Beauty" anti-acne formulations.
Applications
• Dietary Supplements: Capsules and tablets for joint health ("Natural Pain Relief" formulas).
• Pharmaceuticals: API for non-steroidal anti-inflammatory drugs (NSAIDs) with a better safety profile.
• Cosmetics: Serums, toners, and creams for acne-prone or aging skin (Standardized White Willow Bark Extract).
• Sports Nutrition: Recovery supplements to reduce post-workout muscle soreness.
Flow Chart
Our production uses a continuous counter-current extraction process to ensure high yield and purity:
1.Raw Material: Harvesting Salix alba bark (sustainable sourcing).
2.Extraction: Water/Ethanol extraction at controlled temperatures to preserve the glycoside structure.
3.Concentration: Vacuum evaporation.
4.Purification: Chromatography column separation to remove tannins and impurities.
5.Crystallization: Controlled cooling crystallization to achieve D-Salicin purity >98%.
6.Drying & Milling: Spray drying or vacuum drying followed by micronization.
Quality Standard of Lactoferrin
Product: D-Salicin 98%
CAS No.: 138-52-3
| Item | Specification | Result |
| Appearance | White crystalline powder | Conforms |
| Assay (HPLC) | ≥98.0% | 98.68% |
| Moisture Content | ≤5% | Conforms |
| Loss on Drying | ≤5.0% | Conforms |
| Ash Content | ≤0.5% | Conforms |
| Heavy Metals (Pb) | ≤5 ppm | Conforms |
| Total Bacteria Count | ≤1000 CFU/g | Conforms |
| Microbiology | Total Plate Count < 1000 CFU/g | Conforms |
| Solubility | Freely soluble | Conforms |
Method of Analysis of Lactoferrin
We utilize RP-HPLC (Reverse Phase High-Performance Liquid Chromatography) for assay determination.
• Column: C18
• Detector: UV at 270 nm
• Mobile Phase: Methanol : Water
• Importance: HPLC allows us to distinguish D-Salicin from other salicylates (like salicortin) to ensure the precise dosage of the active glucoside.
Reference Chromatogram of Lactoferrin Reference Substance
The chromatogram shows a single, symmetrical peak for D-Salicin at the specific retention time. No significant secondary peaks are observed, confirming the high purity (>98%) required for pharmaceutical and high-end cosmetic use.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Hydrolysis Risk: Salicin can hydrolyze into saligenin and glucose in acidic conditions or if exposed to moisture.
• Stability Data: Samples stored at 25°C/60% RH in double-lined polyethylene bags inside fiber drums remained stable for 2 years.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance.
• Contraindications: Should not be used by individuals allergic to aspirin or salicylates.
• Storage: Store in a cool, dry place. Hygroscopic; keep container tightly closed to prevent clumping and degradation.
Customer Comments
Operations Director, German Pharma Co.
2026.02.04
★★★★☆
Operations Director, German Pharma Co.
2026.02.04
★★★★☆
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FAQ
How does D-Salicin compare to Aspirin?
D-Salicin is the natural precursor. It takes longer to act (since it must be metabolized) but has a longer duration of action and causes significantly less gastric irritation than synthetic aspirin.
Can I use this in organic formulations?
Yes, our D-Salicin is derived from natural Salix alba bark. We can provide documentation to support organic product certification (check specific certifying body requirements).
What is the solubility?
D-Salicin is moderately soluble in water and soluble in alcohol. For cosmetic formulations, it can be dissolved in the water phase, usually with mild heating.
References
1.Vlachojannis, J.E., et al. (2009). "Willow species and aspirin: different mechanism of action." Phytotherapy Research.
2.Mahdi, J.G., et al. (2006). "The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative action." Cell Proliferation.
3.Schmid, B., et al. (2001). "Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial." Phytotherapy Research.
4.Shara, M., et al. (2015). "Efficacy and safety of White Willow Bark (Salix alba) extracts." Phytotherapy Research.
5.Gopaul, R., et al. (2011). "Salicin as a cosmetic ingredient: Exfoliation and anti-aging benefits." Journal of Cosmetic Science.
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