Chondroitin sulfate
Chondroitin Sulfate Sodium Manufacturer | Joint Health Powerhouse (CAS: 9007-28-7) Headline: Chondroitin Sulfate Sodium Manufacturer | USP/EP Grade for Joint Care (CAS: 9007-28-7) Sub-info: Assay 85% - 95% (CPC/HPLC) | Sources: Bovine, Shark, Porcine, Chicken | Low Protein Impurity. USP: • High Purity: Meets strict USP/EP/JP pharmacopoeia standards. • Full Traceability: Sourced from vetted, disease-free animals (BSE/TSE Free). • Optimized Manufacturing: Enzymatic hydrolysis process ensures consistent molecular weight and biological activity.
Introduction
Chondroitin Sulfate Sodium (CAS: 9007-28-7) is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars. It is a major structural component of cartilage, providing resistance to compression.
As a leading manufacturer, we provide high-quality Chondroitin Sulfate derived from premium Bovine, Shark, Porcine, or Avian cartilage. Our product is widely used in the pharmaceutical and nutraceutical industries for its clinically proven ability to support joint mobility, reduce osteoarthritis pain, and inhibit cartilage degradation. We offer various specifications (USP/EP/Food Grade) tailored to your finished product requirements.
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Functions
1.Joint Lubrication & Shock Absorption
Chondroitin Sulfate attracts water into the cartilage matrix, maintaining osmotic pressure. This hydration is essential for cartilage elasticity and its ability to act as a shock absorber during movement.
2.Cartilage Regeneration & Protection
It stimulates chondrocytes to synthesize new cartilage components (Collagen & Proteoglycans) while inhibiting enzymes (like Elastase and Hyaluronidase) that break down cartilage tissue.
3.Anti-Inflammatory Action
Chondroitin Sulfate reduces the presence of inflammatory markers in the synovial fluid, helping to alleviate pain and swelling associated with Osteoarthritis (OA).
Applications
1.Joint Health Supplements
• Classic Pairings: Often formulated with Glucosamine and MSM in tablets/capsules.
• Claim: "Supports joint comfort and flexibility."
2.Pharmaceuticals (Osteoarthritis Treatment)
• Format: Oral tablets or Injectable solutions (Pharma Grade).
• Use: Management of knee and hip osteoarthritis symptoms (SYSADOA - Symptomatic Slow-Acting Drug for Osteoarthritis).
3.Eye Drops (Ophthalmic)
• Use: Used as a viscoelastic agent in cataract surgery and in dry eye formulations to retain moisture.
Flow Chart
Enzymatic Hydrolysis for Purity
1.Raw Material: Fresh Cartilage (Bovine/Shark/Porcine).
2.Cleaning & Grinding: Removal of meat/fat residues.
3.Enzymatic Hydrolysis: Protease digestion to release GAGs.
4.Filtration: Removing insoluble peptides.
5.Oxidation/Decolorization: Ensuring white color.
6.Ultrafiltration: Molecular weight control and desalting.
7.Alcohol Precipitation: Isolating the Chondroitin Sulfate.
8.Drying: Vacuum drying.
9.Milling: Passing 80 Mesh.
10.QC Testing: CPC Titration / HPLC Assay.
Quality Standard of Lactoferrin
Product: Chondroitin Sulfate Sodium (Bovine, USP Grade)
| Item | Specification | Result |
| Appearance | White to off-white powder | Conforms |
| Identification (IR) | Matches Reference Standard | Conforms |
| Assay (CPC Titration) | 90.0% ~ 105.0% (Dry Basis) | 95.2% |
| Assay (HPLC) | ≥ 90.0% | 91.5% |
| Loss on Drying | ≤ 10.0% | 6.5% |
| pH | 5.5 ~ 7.5 | 6.8 |
| Protein | ≤ 6.0% (Dry Basis) | 3.5% |
| Chlorides | ≤ 0.5% | 0.2% |
| Heavy Metals | ≤ 10 ppm | Conforms |
| Total Plate Count | ≤ 1000 cfu/g | < 100 cfu/g |
| Salmonella / E.Coli | Negative | Negative |
Method of Analysis of Lactoferrin
CPC Titration vs. HPLC
• CPC (Cetylpyridinium Chloride) Titration: The most common method (USP/EP) for measuring total Chondroitin content.
• HPLC (Enzymatic): A more specific method that separates and quantifies Chondroitin without interference from other GAGs or proteins. We provide HPLC testing upon request to guarantee no adulteration.
Reference Chromatogram of Lactoferrin Reference Substance
(Visual Placeholder: Electrophoresis or HPLC Graph)
The chromatogram confirms the identity of Chondroitin Sulfate and verifies the absence of adulterants like Maltodextrin or Sodium Hexametaphosphate.
Stability and Safety
Stability Studies
• Shelf Life: 36 months (3 Years).
• Conditions: Very stable in dry powder form. Store in airtight containers.
• Hygroscopic: The powder absorbs moisture easily; exposure to air should be minimized during production.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance.
• Handling: Standard PPE (Dust mask, gloves).
• Storage: Store in a cool, dry place. Keep away from moisture.
Customer Comments
Quality Manager, Supplement Brand (USA)
2026.03.03
★★★★☆
Plant Manager, Contract Manufacturer (Germany)
2026.03.03
★★★★☆
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FAQ
What is the difference between Bovine, Porcine, and Shark Chondroitin?
• Bovine: Most common, derived from cow cartilage (trachea). High Chondroitin-4-Sulfate. • Shark: Derived from shark cartilage. High Chondroitin-6-Sulfate. Often marketed as "Premium" or for specialized bioactivity. • Porcine: Derived from pig. Cost-effective. We supply all types with full traceability.
Which testing method do you use, CPC or HPLC?
Our standard COA uses CPC Titration as per USP/EP monographs. However, we can also provide HPLC (Enzymatic HPLC) results if your specific application requires high-specificity testing to rule out specific adulterants.
Is your Chondroitin suitable for Pet Supplements?
Yes! A large portion of our volume goes to the Pet Health market (Dog/Cat Joint Chews). We offer cost-effective Food Grade (85-90%) options specifically for animal nutrition.
References
1.Clegg, D. O., et al. (2006). Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine.
2.Volpi, N. (2009). Quality of different chondroitin sulfate preparations in relation to their therapeutic activity. Journal of Pharmacy and Pharmacology.
3.Uebelhart, D. (2008). Clinical review of chondroitin sulfate in osteoarthritis. Osteoarthritis and Cartilage.
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