Sodium Deoxycholate
odium Deoxycholate Manufacturer | Cell Lysis & Fat Dissolving API (CAS: 302-95-4) Source: Synthetic / Bovine Bile Origin Purity: 98% Certifications: ISO9001, TSE/BSE Free Solution : High Solubility
Introduction
Sodium Deoxycholate (CAS: 302-95-4; Chemical Formula: C${24}$H${39}$NaO$_4$) is the sodium salt of deoxycholic acid, a secondary bile acid naturally produced in the liver. It is a powerful ionic detergent used extensively in biochemical research for cell lysis and membrane protein solubilization.
In the pharmaceutical and cosmetic industries, it has gained prominence as the active ingredient in lipolysis injections (for submental fat reduction) due to its ability to disrupt adipocyte cell membranes, leading to permanent fat cell destruction.
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Keywords：
trypsin
manufacturer
digestive
Functions
1.Adipocytolysis (Fat Cell Destruction)
Sodium Deoxycholate acts as a cytolytic agent. When injected into subcutaneous fat, it disrupts the cell membrane of adipocytes (fat cells), causing them to break down. The body's immune system then naturally clears the cellular debris, resulting in a reduction of localized fat deposits.
2.Biological Detergent (Cell Lysis)
In biotechnology, it is a critical reagent for lysing cells and solubilizing membrane-bound proteins. It is effective in stripping viruses and is a key component in vaccine manufacturing (e.g., flu vaccines) for virus splitting.
3.Solubilizing Agent
It improves the aqueous solubility of hydrophobic drugs (such as Amphotericin B), enhancing their bioavailability and stability in liquid formulations.
Applications
• Aesthetic Medicine: The API for FDA-approved injections (e.g., Kybella generics) treating submental fullness ("double chin").
• Pharmaceutical Formulation: Used as an excipient and solubilizer for parenteral drugs and vaccines.
• Biochemical Research: Essential component in cell lysis buffers (e.g., RIPA buffer) and for protein extraction.
• Culture Media: Selective agent in microbiological media (e.g., MacConkey agar) to inhibit Gram-positive bacteria.
Flow Chart
Quality Standard of Lactoferrin
Product: Sodium Deoxycholate (Pharma Grade)
CAS No.: 302-95-4
| Item | Specification | Result |
| Appearance | White to off-white crystalline powder | Conforms |
| Assay (Titration) | 98.0% | 99.1% |
| Solubility (5% in water) | Clear and colorless | Conforms |
| pH (5% Solution) | 7.5 – 9.5 | 8.2 |
| Loss on Drying | 5.0% | 2.8% |
| Sodium Cholate | 2.0% | 0.8% |
| Heavy Metals (Pb) | ＜20 ppm | < 10 ppm |
| Bacterial Endotoxins | / | Conforms |
Method of Analysis of Lactoferrin
Sodium Deoxycholate — HPLC Detection Method
Refractive Index Detector cell temperature: 40°C;
Mobile phase: Acetonitrile : Methanol : Sodium Dihydrogen Phosphate (0.78 g/L, pH = 3, adjusted with phosphoric acid) = 30 : 40 : 32;
Injection concentration: 3 mg/mL, injection volume: 150 μL;
Column temperature: 30°C or 35°C;
Sample solvent: Methanol : Mobile phase = 1 : 9;
Wavelength: 205 nm
Chromatographic column: C18, 5 μm, 4.6 mm × 250 mm
Reference Chromatogram of Lactoferrin Reference Substance
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Hygroscopicity: The product is hygroscopic. It must be stored in tightly sealed containers to prevent moisture absorption, which can cause clumping.
• Stability Data: Stable under room temperature. Accelerated stability tests at 40°C/75% RH show minimal degradation if packaging integrity is maintained.
Safety & Handling (MSDS Summary)
• Signal Word: Warning (Irritant).
• Hazard: Harmful if swallowed. Causes skin and serious eye irritation.
• Handling: Avoid dust formation. Use in a fume hood or well-ventilated area. Wear protective gloves and eye protection.
• Storage: Store at room temperature (15-25°C). Keep container tightly closed in a dry and well-ventilated place.
Customer Comments
Production Manager, Aesthetic Pharma Co., Brazil
2026.02.25
★★★★☆
QA Director, Biotech Firm, India
2026.02.25
★★★★☆
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FAQ
Is your Sodium Deoxycholate animal-derived or synthetic?
We offer both. Our standard grade is derived from bovine bile (TSE/BSE free certified). We also offer a Synthetic Grade for customers requiring strictly non-animal origin materials for specialized pharma applications.
Can this be used for Kybella-type generic formulations?
Yes, our API grade meets the purity and safety standards required for injectable lipolysis formulations. We can support with technical documentation for your regulatory filing.
What is the difference between Sodium Deoxycholate and Deoxycholic Acid?
Deoxycholic Acid is the free acid form and is insoluble in water. Sodium Deoxycholate is the salt form, which is highly water-soluble, making it the preferred form for aqueous injections and biological buffers.
References
1.Rotunda, A.M., et al. (2004). "Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation." Dermatologic Surgery.
2.Stryer, L. (1995). Biochemistry. (Mechanism of bile salts).
3.FDA Access Data. (2015). "Kybella (deoxycholic acid) injection." Highlights of Prescribing Information.
4.Helenius, A., et al. (1975). "Solubilization of membranes by detergents." Biochimica et Biophysica Acta.
5.Lasker, S.E., et al. (2009). "Bile salts as absorption enhancers." Journal of Pharmaceutical Sciences.
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