Cetyl Tranexamate HCl
Cetyl Tranexamate HCl Manufacturer | Advanced Whitening Agent (CAS: 913541-96-5) Headline: Premier Cetyl Tranexamate HCl Manufacturer | 98% Purity Lipophilic TXC (CAS: 913541-96-5) Sub-info: Oil-Soluble Tranexamic Acid Derivative | Deep Skin Penetration | High Stability Deep Dermal Absorption | No Skin Irritation | Ready Stock for Global Shipping
Introduction
Cetyl Tranexamate HCl (TXC) is a revolutionary lipophilic derivative of Tranexamic Acid, chemically known as trans-4-(Aminomethyl)cyclohexanecarboxylic acid hexadecyl ester hydrochloride. While traditional Tranexamic Acid is water-soluble and struggles to penetrate the skin barrier, the cetyl ester modification significantly enhances its lipophilicity.
This structural optimization allows Cetyl Tranexamate HCl to easily permeate the stratum corneum and reach the melanocytes deep within the epidermis. It is designed for high-end cosmetic formulations targeting stubborn pigmentation, melasma, and erythema, offering superior bioavailability compared to standard whitening agents.
Category：
Keywords：
tranexamate
tranexamic
Functions
Cetyl Tranexamate HCl acts as a multi-pathway inhibitor of melanogenesis and inflammation.
1.Deep Penetration & Bioavailability (MOA):
The unique hydrocarbon chain (Cetyl group) transforms the molecule into an amphiphilic structure, allowing it to bypass the skin's lipid barrier 6-7 times more effectively than pure Tranexamic Acid. Once absorbed, esterases in the skin cells slowly release active Tranexamic Acid for sustained action.
2.Plasmin Pathway Inhibition:
It inhibits the binding of plasminogen to keratinocytes, thereby blocking the formation of plasmin. This reduces the release of Arachidonic Acid and Prostaglandins (PGE2), which are key triggers for melanocyte activation and inflammation.
3.Anti-Inflammatory & Anti-Redness:
By suppressing the inflammatory cascade, it effectively treats "redness-prone" skin and post-inflammatory hyperpigmentation (PIH), making it ideal for sensitive skin whitening.
Applications
• Whitening Serums & Ampoules: High-potency spot correctors targeting age spots and melasma.
• Oil-Based Formulations: Unlike water-soluble acids, it is compatible with emulsions, creams, and facial oils without recrystallization issues.
• Sensitive Skin Care: Used in "soothing + whitening" dual-action creams due to its non-irritating nature.
• After-Sun Repair: Helps mitigate UV-induced inflammation and subsequent darkening.
Flow Chart
Precision Organic Synthesis Process:
1.Esterification: Reaction of Tranexamic Acid with Cetyl Alcohol under acidic catalysis.
2.Hydrochloride Formation: Stabilization using Hydrochloric Acid to form the HCl salt.
3.Crystallization: Controlled cooling in organic solvents to maximize crystal purity.
4.Recrystallization: Critical step to remove unreacted Cetyl Alcohol and impurities.
5.Centrifugation & Washing: Removal of solvent residues.
6.Vacuum Drying: Low-temperature drying to prevent thermal degradation.
7.Micronization: Milling to fine powder for better dispersibility in cosmetic bases.
Quality Standard of Lactoferrin
Spec: Cetyl Tranexamate HCl 98% (Cosmetic Grade)
| Item | Specification | Result |
| Appearance | White to Off-white Crystalline Powder | Conforms |
| Assay (HPLC) | ≥ 98.0% | 98.8% |
| Loss on Drying | ≤ 0.5% | 0.45% |
| Heavy Metals | ≤ 10 ppm | Conforms |
| Arsenic (As) | ≤ 1 ppm | Conforms |
| Ammonium(NH4) | ≤ 0.02% | Conforms |
| Sulfate(SO4) | ≤ 0.02% | Conforms |
Method of Analysis of Lactoferrin
• HPLC Analysis: We employ Reverse-Phase HPLC to strictly control the content of the active ester and monitor potential hydrolysis products.
Reference Chromatogram of Lactoferrin Reference Substance
(Description): The HPLC chromatogram exhibits a major peak at approximately 12.5 min. No significant peaks are observed for free Tranexamic Acid (which would appear much earlier) or Cetyl Alcohol, confirming the completeness of the esterification reaction.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• pH Stability: Stable in formulations with pH 3.5 - 6.5.
• Thermal Stability: Tests show the molecule remains stable at elevated temperatures (45°C) for 3 months, but avoid prolonged heating >80°C during formulation.
• Data: 12-month long-term stability data (25°C) confirms Assay remains >97.5%.
Safety & Handling (MSDS Summary)
• Skin Safety: Classified as a non-irritant at recommended dosage (1-3%).
• Handling: Wear gloves and goggles. Avoid inhaling dust.
• Storage: Store in a cool, dry place. Keep container tightly closed to prevent moisture absorption, which could trigger hydrolysis.
Customer Comments
R&D Director, Korean Skincare Brand
2026.02.13
★★★★☆
Formulation Chemist, US Indie Beauty Label
2026.02.13
★★★★☆
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FAQ
What is the recommended usage rate?
For effective whitening and spot reduction, we recommend a dosage of 1.0% to 3.0%. It is effective even at lower concentrations due to its enhanced penetration.
How should I formulate with Cetyl Tranexamate HCl?
It is oil-soluble. We recommend dissolving it in the oil phase (or a solvent like Propanediol/Ethanol) at 60-70°C before emulsification. It is compatible with most cosmetic ingredients but avoid strong alkalis which may cause hydrolysis.
Is it safe for sensitive skin?
Yes. Unlike exfoliating acids (AHAs/BHAs) or unstable Vitamin C, Cetyl Tranexamate HCl functions by calming inflammation and inhibiting melanin pathways without causing skin irritation or photosensitivity. It is excellent for barrier-compromised skin.
References
1.Tengamnuay, P., et al. (2006). "Development of tranexamic acid emulgel for melasma treatment."
2.Hsieh, P. W., et al. (2012). "Cetyl tranexamate HCl inhibits UV-induced pigmentation by reducing arachidonic acid release." Journal of Dermatological Science.
3.Lee, J. H., (2016). "Efficacy of lipophilic tranexamic acid derivative in the treatment of melasma." Journal of Cosmetic Dermatology.
4.Cosmetic Ingredient Review (CIR). "Safety Assessment of Tranexamic Acid and its derivatives."
5.Maeda, K., & Naganuma, M. (1998). "Topical trans-4-aminomethylcyclohexanecarboxylic acid prevents ultraviolet radiation-induced pigmentation."
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