Lumbrokinase
Lumbrokinase Manufacturer | Potent Fibrinolytic Enzyme Headline: Premium Lumbrokinase Manufacturer | Oral Fibrinolytic Enzyme (CAS: 556743-18-1) Sub-headline: ≥12,000 IU/mg Activity | Earthworm Extract | Cardiovascular Support Unique Selling Proposition (USP): • Targeted Clot Dissolution: Specifically hydrolyzes fibrin and activates plasminogen, helping to dissolve blood clots without significantly affecting overall hemostasis. • High Potency: Standardized activity levels (e.g., ≥12,000 IU/mg) ensure effective dosage for cardiovascular health formulations. • Enteric Stability: Processed to maintain enzymatic activity, suitable for enteric-coated capsule formulations.
Introduction
Lumbrokinase is a group of proteolytic enzymes extracted from the earthworm (Lumbricus rubellus). It typically appears as a yellowish powder.
Unlike other fibrinolytic agents (like Nattokinase), Lumbrokinase possesses a unique dual mechanism: it can dissolve fibrin directly and also activate the body's own plasminogen system. This makes it a highly valued ingredient in the cardiovascular supplement market for supporting healthy blood viscosity and circulation, particularly for stroke prevention and deep vein thrombosis (DVT) management.
Lumbrokinase is a high-quality bioenzyme ingredient widely used in pharmaceutical and biotechnology industries. Produced through advanced extraction and purification technology, Lumbrokinase ensures stable activity, controlled purity, and reliable batch consistency. It features good solubility and strong compatibility with different formulation systems, making it suitable for tablets, capsules, powders, and liquid products. Compared with ordinary enzyme materials, Lumbrokinase helps manufacturers improve product stability, reduce quality risks, and enhance production efficiency. Strict quality control and complete testing documentation support safe storage, convenient transportation, and long shelf life. By choosing Lumbrokinase, customers can obtain dependable supply, competitive cost control, and professional technical support for long-term development.
Category：
Keywords：
lumbrokinase
fibrinolytic
Lumbrokinase
Functions
1.Fibrinolysis (Clot Busting)
• Mechanism: Direct hydrolysis of fibrin and activation of plasminogen.
• Action: Dissolves existing micro-thrombi and prevents the formation of new clots, improving blood flow in ischemic tissues.
2.Blood Viscosity Reduction
• Mechanism: Reduces fibrinogen levels and platelet aggregation.
• Action: Lowers blood viscosity ("thinning" the blood naturally), which reduces the workload on the heart and improves microcirculation.
3.Ischemic Protection
• Mechanism: Enhances perfusion to the brain and heart.
• Action: Clinically used in some regions to support recovery after ischemic stroke and to manage angina pectoris.
Applications
1.Cardiovascular Supplements
• Application: Capsules for Stroke Prevention and DVT.
• Why it works: Its oral bioavailability (when enteric coated) and specific affinity for fibrin make it a potent alternative to aspirin for some users.
2.Circulation Support
• Application: Formulas for cold hands/feet and varicose veins.
• Why it works: Improves microcirculation by clearing fibrin deposits in small capillaries.
3.Pharmaceutical (Regional)
• Application: Oral drugs for ischemic cerebrovascular disease (approved in China/Korea).
• Why it works: Validated clinical efficacy in reducing neurological deficits.
Flow Chart
Quality Standard of Lactoferrin
Product: Lumbrokinase Powder
Source: Lumbricus rubellus
| Item | Specification | Result |
| Appearance | Yellowish powder | Conforms |
| Specific activity | ≥ 20,000 | 21,500 |
| Potency | Lumbrokinase unit activity/mg ≥12000 | 16054 |
| Loss on Drying | ≤ 6.0% | 3.2% |
| pH (1% solution) | 6.0 - 8.0 | 7.1 |
| Pb | ≤ 1.5 ppm | Conforms |
Method of Analysis of Lactoferrin
Test Method: Fibrin Plate Method / Chromogenic Assay
• Fibrin Plate: Measures the diameter of the lysis zone on a fibrin agar plate caused by the enzyme, compared to a standard urokinase or lumbrokinase reference.
• Specific Activity: Calculated as Units per milligram of protein.
Reference Chromatogram of Lactoferrin Reference Substance
(Description)
SDS-PAGE electrophoresis reveals a cluster of protein bands typically between 25-32 kDa, representing the different isoenzymes that make up the lumbrokinase complex.
Stability and Safety
Stability Studies
• Thermostability: Unstable at high temperatures (>50°C).
• Acid Sensitivity: Highly sensitive to stomach acid. Must be enteric-coated or encapsulated in acid-resistant capsules for oral efficacy.
• Shelf Life: 24 Months when stored at 2-8°C (Refrigerated). Room temperature storage significantly reduces activity over time.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous biological substance.
• Handling: Avoid inhalation (enzyme dust can cause allergies).
• Storage: Refrigerate (2-8°C). Keep tightly sealed away from moisture.
Customer Comments
Formulation Scientist, HeartHealth Labs (USA)
2026.02.12
★★★★☆
Production Manager, VitaCaps (Canada)
2026.02.12
★★★★☆
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FAQ
What is the difference between Lumbrokinase and Nattokinase?
Lumbrokinase is generally considered stronger and more specific to fibrin. It can dissolve clots directly and activate the body's system. Nattokinase primarily works by degrading fibrin directly. Lumbrokinase is often used for more acute or higher-risk circulatory support.
How should it be taken?
It must be taken on an empty stomach (1 hour before or 2 hours after meals) to ensure absorption. It requires enteric coating to survive stomach acid.
Is there a bleeding risk?
As with all blood thinners, there is a potential risk, especially if combined with drugs like Warfarin or Heparin. It should be used under medical supervision in such cases.
References
1.Mihara, H., et al. (1991). "A novel fibrinolytic enzyme extracted from the earthworm, Lumbricus rubellus." Japanese Journal of Physiology.
2.Tang, Y.J., et al. (2017). "Lumbrokinase for secondary prevention of ischemic stroke." Cochrane Database of Systematic Reviews.
3.Cooper, E.L., et al. (2004). "Earthworms: sources of antimicrobial and anticancer molecules." Advances in Experimental Medicine and Biology.
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