3-O-Ethyl-L-ascorbic acid
3-O-Ethyl-L-Ascorbic Acid Manufacturer | Highly Stable Vitamin C Ether (CAS: 86404-04-8) Headline: Premium 3-O-Ethyl Ascorbic Acid Manufacturer | 99% Purity Stabilized Vitamin C (CAS: 86404-04-8) Sub-info: Amphiphilic (Water & Oil Soluble) | Non-Oxidizing Formula | >99% Vitamin C Content equivalent USP: Highest Vitamin C Content (>86%) | Superior Skin Penetration | Ready Stock in Global Warehouses
Introduction
3-O-Ethyl-L-Ascorbic Acid (CAS: 86404-04-8), commonly known as VC Ethyl Ether, is the most advanced stable derivative of Vitamin C currently available. Unlike standard L-Ascorbic Acid which oxidizes rapidly, or Magnesium Ascorbyl Phosphate (MAP) which has low penetration, VC Ethyl Ether combines chemical stability with exceptional bioavailability.
As a specialized B2B manufacturer, we produce High-Purity 3-O-Ethyl Ascorbic Acid (≥99%). Its unique ether structure at the C3 position protects the molecule from oxidation while maintaining a molecular weight very close to pure Vitamin C. It is uniquely Amphiphilic (both lipophilic and hydrophilic), allowing it to permeate the stratum corneum effortlessly and reach the dermis, where it is metabolized into pure ascorbic acid.
Category：
Keywords：
vitamin
acid
Functions
VC Ethyl Ether acts as a direct-acting antioxidant and whitening agent:
1. Direct Tyrosinase Inhibition (MOA):
Unlike other derivatives that must be converted first, 3-O-Ethyl Ascorbic Acid has direct inhibitory activity on tyrosinase. It blocks the polymerization of melanin structural monomers, effectively preventing the formation of dark spots and sun damage.
2. Superior Stability & Potency:
It contains over 86% pure Vitamin C by weight (compared to ~50% in Glucosides). It resists polymerization and oxidation even at high temperatures (up to 60°C) and broad pH ranges, ensuring your product stays clear and potent on the shelf.
3. Collagen Booster:
It repairs skin cell activity and promotes the synthesis of collagen protein, repairing the dermis structure and improving skin elasticity.
4. Anti-Inflammatory & Antioxidant:
It provides strong scavenging of free radicals (ROS) and exhibits significant anti-inflammatory effects, inhibiting the edema caused by sunlight.
Applications
• Whitening Serums: The "Gold Standard" ingredient for high-end brightening formulations (usage 0.5% - 2.0%).
• Anti-Aging Creams: Stimulates collagen without the stinging sensation of pure acid.
• Sunscreen Boosters: Added to SPF products to prevent UV-induced oxidative stress.
• Oil-Based Formulas: Due to its lipophilic nature, it can be used in anhydrous systems or makeup, unlike water-soluble-only derivatives.
Flow Chart
Advanced Etherification Process:
1.Raw Material: High-Purity L-Ascorbic Acid (Vitamin C).
2.Etherification: Selective alkylation at the C3-hydroxyl group using ethyl halide under alkaline conditions.
3.Protection/Deprotection: Using protecting groups to ensure regioselectivity (optional depending on route).
4.Purification: Crystallization and Recrystallization to remove isomers and by-products.
5.Drying: Vacuum drying.
6.Milling: Processing into fine crystalline powder.
7.QC Testing: HPLC Assay and Color stability test.
Quality Standard of Lactoferrin
Spec: 3-O-Ethyl-L-Ascorbic Acid ≥99.0%
| Item | Specification | Result |
| Appearance | White Crystalline Powder | Conforms |
| Assay (HPLC) | ≥ 99.0% | 99.4% |
| Melting Point | 111°C - 116°C | 113.5°C |
| pH (3% Solution) | 3.5 – 5.5 | 4.2 |
| Loss on Drying | ≤ 1.0% | 0.3% |
| Residue on Ignition | ≤ 0.2% | 0.05% |
| Heavy Metals (Pb) | ≤ 10 ppm | < 5 ppm |
| Arsenic (As) | ≤ 2.0 ppm | 0.2 ppm |
| Solubility | Soluble in Water & Oil | Conforms |
Method of Analysis of Lactoferrin
• Analytical Method: High-Performance Liquid Chromatography (HPLC).
• Identity: We use HPLC retention time and Melting Point to confirm identity. Unlike titration, HPLC ensures that the ethyl group is correctly attached at the C3 position, which is critical for its unique stability.
Reference Chromatogram of Lactoferrin Reference Substance
(Description): The HPLC chromatogram displays a single, sharp peak at the retention time specific to 3-O-Ethyl Ascorbic Acid. No peaks for free Ascorbic Acid or over-alkylated byproducts are observed, confirming >99% purity.
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Thermal Stability: Stable at 40°C for 3 months with <1% degradation. Unaffected by light exposure compared to normal Vitamin C.
• Color Stability: Solutions remain clear and colorless (APHA <20) even after prolonged storage, solving the "yellowing" problem of Vitamin C serums.
• pH Stability: Stable at pH 3.0 - 6.0.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous.
• Skin Safety: Non-irritating and non-sensitizing at recommended dosages.
• Handling: Wear mask and gloves.
• Storage: Store in a cool, dry place. While stable, we recommend keeping it sealed to prevent moisture absorption.
Customer Comments
R&D Director, French Dermo-Cosmetic Brand
2026.02.05
★★★★☆
Formulator, Japanese Cosmetic Lab
2026.02.05
★★★★☆
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FAQ
Why is VC Ethyl Ether more expensive than other derivatives?
It has the highest Vitamin C content (~86%) and requires a complex synthesis process to ensure the ethyl group is attached specifically at the C3 position. This structural precision gives it unmatched stability and penetration, offering the best "Value for Effect."
Is it oil soluble or water soluble?
It is Amphiphilic. It dissolves easily in water (up to 20%) and is also soluble in oils/esters, making it extremely versatile for emulsions, toners, and anhydrous sticks.
How do you identify quality?
Quality is identified by Melting Point (111-116°C) and HPLC Purity. Lower quality grades often contain unreacted Vitamin C (causing yellowing) or incorrect isomers.
References
1.Liao, W. C., et al. (2009). "3-O-ethyl ascorbic acid: a stable, vitamin C-derived agent for skin whitening." Cosmetic Science.
2.Jun, H., et al. (2011). "Comparison of the stability and penetration of Vitamin C derivatives." Journal of Cosmetic Dermatology.
3.Stamford, N. P. (2012). "Stability, transdermal penetration, and cutaneous effects of ascorbic acid and its derivatives." Journal of Cosmetic Dermatology.
4.Cosmetic Ingredient Review (CIR). "Safety Assessment of Ethers and Esters of Ascorbic Acid."
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