S-Adenosylmethionine (SAMe)
S-Adenosylmethionine (SAMe) Powder | Premium Methyl Donor Headline: High-Purity S-Adenosylmethionine (SAMe) Manufacturer | Stable Salts (CAS: 17176-17-9) Sub-info: Assay: ≥98% (HPLC) | Form: Tosylate / Butanedisulfonate | Non-GMO & Fermentation Origin USP: High Stability Technology • Cold-Chain Storage • Low Moisture (<1.0%)
Introduction
S-Adenosylmethionine (SAMe) is a naturally occurring cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although the CAS 17176-17-9 refers to the ion itself, our commercial grade is stabilized as S-Adenosylmethionine Disulfate Tosylate or 1,4-Butanedisulfonate, ensuring maximum shelf-life and bioavailability.
Produced via advanced microbial fermentation, our SAMe powder offers a pharmaceutical-grade solution for Nutraceutical formulations targeting mood enhancement, liver detoxification, and osteo-articular health.
Category：
Keywords：
fermentation
tosylate
Functions
1. Universal Methyl Donor (Methylation)
SAMe is the principal methyl donor for methyltransferase enzymes, critical for the synthesis of neurotransmitters (dopamine, serotonin), DNA, phospholipids, and proteins. This mechanism directly supports cognitive function and emotional balance.
2. Joint Health & Cartilage Support
By supplying methyl groups for the synthesis of proteoglycans, SAMe aids in the regeneration of cartilage matrix and reduces joint discomfort associated with osteoarthritis.
3. Liver Health (Transsulfuration)
Through the transsulfuration pathway, SAMe is a precursor to Glutathione (GSH), the body's master antioxidant. This action protects hepatocytes from free radical damage and supports liver detoxification processes.
Applications
Dietary Supplements:
• Mood Support Formulas: Often combined with Folate or Vitamin B12 for depression management.
• Joint Care: A proven alternative to Glucosamine/Chondroitin for mobility.
Pharmaceuticals: Used as a prescription API (Ademetionine) in Europe/Asia for intrahepatic cholestasis and depressive disorders.
Functional Foods: Specialized formulations requiring high-barrier packaging due to hygroscopicity.
Formulation Tip: Due to SAMe's high hygroscopicity, we recommend using it in enteric-coated tablets or alu-alu blister packs to prevent degradation in the stomach and ensure stability.
Flow Chart
Culture Preparation (Yeast Strain) → Fermentation (Controlled pH/Temp) → Cell Separation → Extraction (Acidic Buffer) → Purification (Ion Exchange Chromatography) → Salt Formation (Stabilization with Tosylate/Butanedisulfonate) → Concentration → Lyophilization (Freeze Drying) → Milling (Low Humidity Environment) → Packing (Nitrogen flushed)
Note: Our facility maintains a Relative Humidity (RH) of <30% during packing to ensure the product remains free-flowing and stable.
Quality Standard of Lactoferrin
| Item | Specification | Result |
| Appearance | White to off-white powder | Conforms |
| Assay (HPLC) | ≥ 98.0% (on dried basis) | 99.2% |
| Identification | Matches Reference Standard | Conforms |
| pH (1% Solution) | 2.5 – 3.5 | 2.9 |
| Moisture (Karl Fischer) | ≤ 3.0% (Strict Control) | 1.8% |
| S,S-Isomer (Active Form) | ≥ 75.0% | 78.5% |
| Heavy Metals | ≤ 10 ppm | < 5 ppm |
| Microbiology | ≤ 1,000 cfu/g | < 100 cfu/g |
Method of Analysis of Lactoferrin
We employ High-Performance Liquid Chromatography (HPLC) to verify both purity and the ratio of active isomers.
• Chiral Separation: Our method distinguishes between the biologically active (S,S)-SAMe isomer and the inactive (R,S)-isomer, ensuring you pay for potency, not just weight.
Reference Chromatogram of Lactoferrin Reference Substance
(Imagine a sharp HPLC peak)
The chromatogram exhibits a major peak for S-Adenosylmethionine at the specified retention time, with the S,S-isomer clearly resolved. Impurities such as Adenine and Methylthioadenosine are strictly controlled below limits.
Stability and Safety
Stability Studies
SAMe is notoriously unstable if not handled correctly.
• Shelf Life: 24 months when stored at 2-8°C (Refrigerated).
• Room Temperature: Can withstand short-term excursions during shipping, but long-term storage must be cold.
• Humidity Control: Our study shows rapid degradation at RH >60%. Therefore, our double aluminum foil packaging is non-negotiable for preserving the 98% assay.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous but acidic in solution.
• Storage: Store in a dark, dry place at 2-8°C. Keep container tightly closed.
• Handling: Avoid contact with skin and eyes; the powder is acidic.
Customer Comments
R&D Manager, US Nutraceutical Firm
2026.02.06
★★★★☆
Purchasing Director, Australian Pharma Co.
2026.02.06
★★★★☆
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FAQ
What is the difference between SAMe Tosylate and Butanedisulfonate?
Both are stabilized salts used to prevent SAMe from degrading. Tosylate is the most common commercial form in the US, while Butanedisulfonate is often used in pharmaceutical applications. Both offer excellent stability when manufactured correctly.
Is your SAMe suitable for vegetarians?
Yes. Our SAMe is produced via yeast fermentation (Saccharomyces cerevisiae) and does not contain any animal-derived ingredients.
Why is the S,S-Isomer percentage important?
SAMe exists in two isomeric forms: (S,S) and (R,S). Only the (S,S)-SAMe is biologically active and can bind to methyltransferase enzymes. Our product guarantees a high level of the active S,S form (typically >75%).
References
1.Bottiglieri, T. "S-Adenosyl-L-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule." American Journal of Clinical Nutrition (2002).
2.Mischoulon, D., & Fava, M. "Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence." American Journal of Clinical Nutrition (2002).
3.Najm, W.I., et al. "S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms." BMC Musculoskeletal Disorders (2004).
4.Lieber, C.S. "S-Adenosyl-L-methionine: its role in the treatment of liver disorders." American Journal of Clinical Nutrition (2002).
5.Lu, S.C. "S-Adenosylmethionine." Int J Biochem Cell Biol. (2000).
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