Squalene
Squalene Manufacturer | Plant-Based & High Purity (CAS: 7683-64-9) Headline: Premium Plant-Based Squalene Manufacturer | ≥98% Purity Fermented Origin (CAS: 7683-64-9) Sub-info: Vegan Friendly | Non-Shark Source | HPLC Validated | Cosmetic Sustainable & Cruelty-Free | Excellent Skin Affinity | Ready Stock in US/EU
Introduction
Squalene (CAS: 7683-64-9) is a natural polyunsaturated triterpene hydrocarbon (C30H50) that is structurally identical to the sebum produced by human skin. While historically extracted from deep-sea shark liver oil, modern demand for sustainability has shifted towards Plant-Based sources.
As a leading manufacturer, we provide High-Purity Botanical Squalene (≥98%) produced via advanced Bio-Fermentation or extraction from Olive/Sugarcane. This ensures a cruelty-free, stable, and highly compatible raw material for premium Cosmetics, Nutraceuticals, and Vaccine Adjuvants. It eliminates the risk of ocean pollutants (heavy metals/PCBs) often found in animal-derived sources.
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Keywords：
squalene
manufacturer
plant-based
Functions
Squalene acts as a supreme moisturizer and biological antioxidant.
1. Biomimetic Moisturizing (MOA):
Squalene is a major component (approx. 13%) of human sebum. Its triterpene structure allows it to integrate seamlessly into the skin's lipid barrier, reducing Transepidermal Water Loss (TEWL) and restoring suppleness without a greasy after-feel.
2. Potent Antioxidant Protection:
Due to its six double bonds, Squalene functions as a singlet oxygen quencher, protecting skin lipids from UV-induced peroxidation and environmental stress.
3. Carrier & Penetration Enhancer:
Its high affinity for cell membranes makes it an excellent carrier for other bioactive ingredients, enhancing their penetration and efficacy in topical formulations.
4. Immune Support (Oral):
In nutraceuticals, Squalene facilitates oxygen transport and has been studied for its potential to boost cellular immunity and regulate cholesterol metabolism.
Applications
Premium Skincare: High-end facial oils, anti-aging serums, and moisturizers.
• Why it works: Non-comedogenic and instantly absorbed, it provides a "dry oil" finish.
Vaccine Adjuvants: Used in pharmaceutical emulsions (like MF59) to enhance the body's immune response to antigens.
Functional Foods: Softgels for heart health and anti-fatigue.
Hair Care: Conditioners and hair oils to repair damage and add shine.
Flow Chart
Sustainable Bio-Fermentation Process:
1.Strain Selection: High-yield yeast or algae strains optimized for terpene production.
2.Fermentation: Controlled growth in bioreactors using plant-based carbon sources (sugars).
3.Extraction: Separation of crude Squalene from biomass.
4.Purification: Multi-stage fractional distillation to remove by-products.
5.Refining: Decolorization and deodorization to achieve a clear, odorless liquid.
6.Stabilization: Addition of natural Tocopherols (Vitamin E) to prevent oxidation.
7.Filtration & Packaging: In nitrogen-flushed drums.
Quality Standard of Lactoferrin
Spec: Squalene 98% (Plant Fermentation Grade)
| Item | Specification | Result |
| Appearance | Colorless to off Yellow Clear Liquid | Conforms |
| Odor | Odorless or Faint Characteristic | Conforms |
| Assay (GC) | ≥ 98.0% | 98.5% |
| Acid Value | ≤ 1.0 mg KOH/g | 0.8 |
| Iodine Value | 300 – 450 g I2/100g | 386.5 |
| Saponification Value | ≤ 6.0 mg KOH/g | Conforms |
| Peroxide value | ≤ 5.0 | Conforms |
| Heavy Metals | ≤ 10 ppm | Conforms |
| Microbiology | Total Plate Count ≤ 1000 cfu/g | Conforms |
| Yeast&Molds | ≤ 100cfu/g | Conforms |
Method of Analysis of Lactoferrin
• Gas Chromatography (GC): Used to determine purity and fingerprint the lipid profile.
• Isotope Ratio Mass Spectrometry (IRMS): Optional validation. This advanced method can definitively verify the botanical origin (C13/C12 ratio) to prove it is not shark-derived or petrochemical synthetic.
Reference Chromatogram of Lactoferrin Reference Substance
([Placeholders for Image]: Chromatogram showing a dominant peak at the retention time of Squalene (~22 min). The absence of sterol peaks associated with animal fats confirms purity and plant origin.)
Stability and Safety
Stability Studies
• Shelf Life: 24 months.
• Storage: Squalene is an unsaturated hydrocarbon and is sensitive to oxidation. Must be stored in tightly closed containers, preferably under Nitrogen, in a cool (<20°C), dark place.
• Data: Accelerated stability tests (40°C) show a peroxide value increase after 3 months if not stabilized. We add 0.1% Tocopherol to ensure stability during transport and storage.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous.
• Skin Safety: Non-irritant, non-sensitizing.
• Handling: Standard GMP precautions.
• Spill: Liquid is slippery; use absorbent material to clean up.
Customer Comments
Product Manager, UK Clean Beauty Brand
2026.02.05
★★★★★
Purchasing Director, US Cosmetics Manufacturer
2026.02.05
★★★★★
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FAQ
What is the difference between Squalene and Squalane?
Squalene (with an 'e') is the unsaturated, natural form (C30H50). Squalane (with an 'a') is the hydrogenated, saturated form (C30H62). Squalene has higher antioxidant activity but is less stable; Squalane is extremely stable but lacks the double bonds for ROS scavenging. We supply both.
How do you verify it is not from sharks?
We strictly control our supply chain and use Fermentation or Olive sources. We can provide C14 Radiocarbon Analysis or IRMS data upon request to scientifically prove the non-animal origin.
Is it suitable for sensitive skin?
Yes. Squalene is bio-identical to human sebum, making it one of the most hypoallergenic lipids available. It is safe for sensitive and baby skin formulations.
References
1.Huang, Z. R., et al. (2009). "Biological and pharmacological activities of squalene and related compounds." Molecules.
2.Kelly, G. S. (1999). "Squalene and its potential clinical uses." Alternative Medicine Review.
3.Kohno, Y., et al. (1995). "Kinetic study of quenching reaction of singlet oxygen and scavenging reaction of free radical by squalene in n-butanol." Biochimica et Biophysica Acta.
4.Reddy, L. H., & Couvreur, P. (2009). "Squalene: A natural triterpene for use in disease management and therapy." Advanced Drug Delivery Reviews.
5.Cosmetic Ingredient Review (CIR). "Final Report on the Safety Assessment of Squalane and Squalene."
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