2-Deoxy-D-Glucose
2-Deoxy-D-Glucose (2-DG) Manufacturer | Glycolysis Inhibitor Headline: High Purity 2-Deoxy-D-Glucose Manufacturer | Antiviral & Anticancer Research Reagent (CAS: 154-17-6) Sub-headline: ≥ 98% Purity (HPLC) | Glycolysis Inhibitor | Metabolic Modulator Unique Selling Proposition (USP): • Metabolic Targeting: Acts as a glucose analog to inhibit glycolysis (Warburg Effect), starving cancer cells and virus-infected cells of energy. • Research Grade Purity: Low impurity profile suitable for high-end pharmaceutical synthesis and biological assays. • Application: Diagnostic imaging agents (18F-FDG precursors).
Introduction
2-Deoxy-D-glucose (2-DG), CAS No. 154-17-6, is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen. It appears as a white crystalline powder.
Physiologically, 2-DG competes with glucose for uptake by cells but cannot be fully metabolized. It blocks the glycolysis pathway by inhibiting the enzyme phosphoglucose isomerase. This mechanism makes it a powerful tool in cancer therapy research (starving fast-growing tumors) and antiviral development (inhibiting viral replication by disrupting glycosylation).
Category：
Keywords：
2-deoxy-d-glucose
glycolysis
manufacturer
Functions
1.Glycolysis Inhibition (Cancer Starvation)
• Mechanism: 2-DG is phosphorylated by hexokinase to 2-DG-6-Phosphate, which cannot be further metabolized, leading to accumulation and inhibition of glycolysis.
• Action: Selectively impacts cells with high glucose demand (e.g., tumor cells), inducing energy stress and apoptosis.
2.Antiviral Activity
• Mechanism: Interferes with N-linked glycosylation of viral proteins.
• Action: Prevents the correct folding and assembly of viral envelope proteins, reducing the infectivity of viruses
3.Diagnostic Precursor
• Mechanism: Structural basis for radiotracers.
• Action: Used as the chemical precursor for synthesizing Fludeoxyglucose (18F), the gold standard radiotracer for PET (Positron Emission Tomography) scans.
Applications
1.Cosmetic Research (Anti-Aging)
• Application: Metabolic modulators.
• Why it works: Mimics Caloric Restriction (CR) at the cellular level, potentially activating longevity pathways (Sirtuins) and autophagy.
2.Biological Research
• Application: Cell culture reagent.
• Why it works: Standard inhibitor for studying glucose metabolism and metabolic plasticity in cells.
Flow Chart
1.Starting Material: D-Glucose or Glucal.
2.Protection: Protection of hydroxyl groups (if using glucal route).
3.Reaction: Chemical modification to remove the oxygen at C-2 (e.g., via hydration of D-Glucal).
4.Purification: Ion exchange and decolorization.
5.Crystallization: Solvent crystallization (Ethanol/Water).
6.Recrystallization: To achieve >98% purity and remove heavy metals.
7.Drying: Vacuum drying.
8.Milling: Fine powder production.
9.Packaging: 1kg/Bag or 25kg Drum.
Quality Standard of Lactoferrin
Product: 2-Deoxy-D-glucose (Pharma Grade)
CAS: 154-17-6
| Item | Specification | Result |
| Appearance | White or almost white powder | White powder |
| Identification | Positive | Positive |
| Specific optical rotation | +45.0°--+47.5 ° | +46.3 ° |
| Heavy metals | 10ppm Max | <10ppm |
| Loss on drying | 1.0% Max | 0. 18% |
| Assay | 98.0% | 99.38% |
| Residue on ignition | 0.2% Max | 0.05% |
| Conclusion | Conform with in house standard | |
Method of Analysis of Lactoferrin
Test Method: HPLC (High-Performance Liquid Chromatography)
• Detector: Refractive Index (RI) or ELSD (since sugars have poor UV absorption).
• Column: Carbohydrate column (e.g., Amino column).
• Mobile Phase: Acetonitrile : Water.
• Identification: NMR and IR spectroscopy match reference.
Reference Chromatogram of Lactoferrin Reference Substance
Stability and Safety
Stability Studies
• Hygroscopicity: Slightly hygroscopic.
• Stability: Stable under normal conditions.
• Shelf Life: 24 Months when stored in a cool, dry place.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous substance.
• Handling: Standard laboratory safety.
• Storage: Store at room temperature (15-25°C). Keep container tightly closed.
Customer Comments
"Passed our incoming QC for synthesizing imaging tracers. Good solubility."
2026.03.21
★★★★☆
Production Chemist, Radiopharma Solutions (Germany)
2026.03.21
★★★★☆
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FAQ
Is this suitable for human consumption?
Our standard product is Research/API Intermediate Grade. Any use for human consumption (like the authorized COVID drug in India) requires specific regulatory approval and GMP finished dosage manufacturing.
What is the difference between 2-DG and Glucose?
Structurally, 2-DG lacks one oxygen atom at the 2nd carbon position. This small change allows it to enter the cell but stops it from generating energy, effectively "jamming" the cellular engine.
Can it be used for ketogenic diet research?
Yes, it is often used in metabolic research to mimic the effects of carbohydrate restriction and ketosis induction.
References
1.Landau, B.R., et al. (1958). "The metabolism of 2-deoxy-D-glucose." Journal of Biological Chemistry.
2.Zhang, D., et al. (2014). "2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells..." Cancer Letters.
3.Mahalapbutr, P., et al. (2020). "Molecular mechanism of 2-deoxy-D-glucose inhibition of SARS-CoV-2..." Journal of Biomolecular Structure and Dynamics.
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