Lactonic Sophorolipid
Lactonic Sophorolipid Manufacturer | Natural Anti-Acne Biosurfactant (CAS: 148409-20-5) Headline: Lactonic Sophorolipid Biosurfactant | The Natural Antimicrobial Solution (CAS: 148409-20-5) Sub-info: Lactonic Content ≥ 60% | 100% Bio-based Fermentation | COSMOS/Ecocert Compliant. USP: • Potent Antimicrobial: Specifically targets C. acnes and S. aureus without irritation. • Green Chemistry: Produced via yeast fermentation (Starmerella bombicola); fully biodegradable. • Dual Function: Acts as both a bioactive ingredient (Anti-acne/Anti-dandruff) and a mild surfactant.
Introduction
Lactonic Sophorolipid (CAS: 148409-20-5) is a glycolipid biosurfactant produced by the fermentation of yeast (Candida bombicola / Starmerella bombicola) using vegetable oils and glucose.
While Sophorolipids exist in both acidic and lactonic forms, the Lactonic form is the powerhouse for biological activity. Unlike the acidic form (which is a better foamer), our Lactonic Sophorolipid is engineered for superior antibacterial and antifungal efficacy. It is the ideal natural alternative to synthetic biocides in "Clean Beauty" formulations, tackling acne, dandruff, and body odor effectively.
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Keywords：
aescin
triterpenoid
manufacturer
Functions
1.Targeted Anti-Acne Activity
Lactonic Sophorolipids disrupt the cell membranes of Cutibacterium acnes (formerly P. acnes). Clinical data suggests significant reduction in acne lesions and sebum production at low concentrations (0.5% - 1.0%).
2.Anti-Dandruff & Scalp Care
Effectively inhibits Malassezia fungi, the primary cause of dandruff, while being gentler on the scalp barrier compared to traditional zinc pyrithione or climbazole.
3.Natural Deodorizing
By controlling the growth of odor-causing bacteria (e.g., Corynebacterium), it serves as an excellent active ingredient for aluminum-free deodorants.
Applications
1.Functional Skincare (Acne Treatment)
• Products: Acne Serums, Spot Treatments, Oil-Control Cleansers.
• Benefit: Provides "Treat + Cleanse" action; lowers surface tension to help other actives penetrate.
2.Personal Care (Hair & Body)
• Products: Anti-dandruff Shampoos, Natural Deodorants, Intimate Washes.
• Benefit: Maintains microbiome balance; non-irritating to sensitive mucous membranes.
3.Household Cleaning
• Products: Fruit & Veggie Wash, Pet Shampoos.
• Benefit: Removes pesticide residues and kills bacteria safely (Food Grade available).
Flow Chart
Sustainable Fermentation Process
1.Fermentation: Inoculation of Starmerella bombicola in a medium of Glucose (Sugar source) + Vegetable Oil (Fatty acid source).
2.Bioconversion: Yeast converts substrates into crude Sophorolipids (mixture of Acidic & Lactonic).
3.Separation: Gravity separation/Centrifugation.
4.Purification (Crucial): Crystallization or Solvent extraction to enrich the Lactonic form.
5.Filtration: Removing yeast biomass.
6.Concentration: Vacuum evaporation.
7.Drying/Formulation: Available as viscous liquid or powder (depending on grade).
8.QC Testing: HPLC for Lactonic/Acidic ratio.
9.Packaging: HDPE Drums.
Quality Standard of Lactoferrin
Product: Lactonic Sophorolipid (Cosmetic Grade)
| Item | Specification | Result |
| Appearance | Dark yellow to amber viscous liquid | Conforms |
| Solid Content | ≥ 50.0% (or ≥ 95% for powder) | 52.5% |
| Total Sophorolipids | ≥ 50.0% | 51.8% |
| Lactonic Form Ratio | ≥ 60.0% (of total active) | 65.0% (High Activity) |
| pH (10% Solution) | 5.0 ~ 7.0 | 6.2 |
| Surface Tension | ≤ 40 mN/m | 36 mN/m |
| Heavy Metals (Pb) | ≤ 10 ppm | Conforms |
| Arsenic (As) | ≤ 2.0 ppm | Conforms |
| Microbiology | Total Plate Count < 100 cfu/g | < 10 cfu/g |
| Yeast & Mold | < 10 cfu/g | Negative |
Method of Analysis of Lactoferrin
HPLC-ELSD or LC-MS
• Why: Traditional titration cannot distinguish between Acidic and Lactonic forms effectively. We use HPLC to quantify the specific Lactonic Sophorolipid content, ensuring you get the antimicrobial potency you pay for.
Reference Chromatogram of Lactoferrin Reference Substance
(Visual Placeholder: HPLC Separation Graph)
The chromatogram clearly separates the Acidic Sophorolipid (earlier elution) and Lactonic Sophorolipid (later elution) peaks. Our batch data confirms a high peak area ratio for the Lactonic form.
Stability and Safety
Stability Studies
• Shelf Life: 18 months.
• Temperature: Stable at temperatures up to 80°C (suitable for hot process formulations).
• pH Stability: Active over a broad pH range (pH 4.0 - 9.0), but antimicrobial efficacy is optimal at pH 5.0 - 7.0.
• Data: No phase separation or significant degradation of lactone rings observed after 3 months at 45°C.
Safety & Handling (MSDS Summary)
• Classification: Non-hazardous. Biodegradable.
• Skin/Eye: Mild to non-irritating (unlike SLS/SLES).
• Handling: Standard hygiene.
• Storage: Store in a cool place. Shake well before use if stratification occurs (natural for biosurfactants).
Customer Comments
Formulation Chemist, Green Cleaning Brand (Germany)
2026.02.28
★★★★☆
Product Manager, Skincare Brand (Korea)
2026.02.28
★★★★☆
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FAQ
What is the difference between Lactonic and Acidic Sophorolipids?
• Acidic: Higher water solubility, better foaming. Used for cleaning/detergency. • Lactonic: Lower water solubility, superior antimicrobial/antifungal activity. Used for acne treatment, deodorants, and preservation boosting. We supply both, but this page features the Lactonic-rich grade.
Can I use this as a primary surfactant?
It is a low-foaming surfactant. In cleansers, it is best used as a co-surfactant (to reduce irritation of anionic surfactants) or as an active ingredient (for its antibacterial properties) rather than a primary foamer.
Is it soluble in water?
Pure Lactonic Sophorolipid has low water solubility. However, our commercial grade is usually a mixture or supplied in a solvent/co-surfactant system that makes it dispersible in water.
References
1.Van Bogaert, I. N., et al. (2007). Microbial production and application of sophorolipids. Applied Microbiology and Biotechnology.
2.Kim, K., et al. (2002). Antibacterial activity of sophorolipids against Propionibacterium acnes and Staphylococcus epidermidis. Journal of Microbiology and Biotechnology.
3.Dengle-Pulate, V., et al. (2014). Antimicrobial and antibiotic-potentiating activity of sophorolipids from Starmerella bombicola against pathogenic bacteria. Natural Product Research.
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